scholarly journals Chronic Ethanol Exposure Selectively Inhibits the Influenza-Specific CD8 T Cell Response During Influenza A Virus Infection

2014 ◽  
Vol 38 (9) ◽  
pp. 2403-2413 ◽  
Author(s):  
Emily A. Hemann ◽  
Jodi L. McGill ◽  
Kevin L. Legge
Keyword(s):  
T Cell ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Cell Response ◽  
Influenza A ◽  
Cd8 T Cell ◽  
Ethanol Exposure ◽  
T Cell Response ◽  
Chronic Ethanol Exposure ◽  
Influenza A Virus Infection

scholarly journals Influenza A Virus Infection Results in a Robust, Antigen-Responsive, and Widely Disseminated Foxp3+ Regulatory T Cell Response

2011 ◽  
Vol 86 (5) ◽  
pp. 2817-2825 ◽  
Author(s):  
R. J. Betts ◽  
N. Prabhu ◽  
A. W. S. Ho ◽  
F. C. Lew ◽  
P. E. Hutchinson ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Regulatory T Cell ◽  
Cell Response ◽  
Influenza A ◽  
T Cell Response ◽  
Influenza A Virus Infection

scholarly journals Human Influenza A Virus–Specific CD8+ T-Cell Response Is Long-lived

2015 ◽  
Vol 212 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Carolien E. van de Sandt ◽  
Marine L. B. Hillaire ◽  
Martina M. Geelhoed-Mieras ◽  
Albert D. M. E. Osterhaus ◽  
Ron A. M. Fouchier ◽  
...  
Keyword(s):  
T Cell ◽  
Influenza A Virus ◽  
Cell Response ◽  
Influenza A ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Human Influenza

scholarly journals Overlapping Peptides Elicit Distinct CD8+ T Cell Responses following Influenza A Virus Infection

2020 ◽  
Vol 205 (7) ◽  
pp. 1731-1742
Author(s):  
Lisa M. Assmus ◽  
Jing Guan ◽  
Ting Wu ◽  
Carine Farenc ◽  
Xavier Y. X. Sng ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Influenza A Virus Infection

scholarly journals Potential Role of Invariant NKT Cells in the Control of Pulmonary Inflammation and CD8+ T Cell Response during Acute Influenza A Virus H3N2 Pneumonia

2011 ◽  
Vol 186 (10) ◽  
pp. 5590-5602 ◽  
Author(s):  
Christophe Paget ◽  
Stoyan Ivanov ◽  
Josette Fontaine ◽  
Fany Blanc ◽  
Muriel Pichavant ◽  
...  
Keyword(s):  
T Cell ◽  
Influenza A Virus ◽  
Cell Response ◽  
Influenza A ◽  
Potential Role ◽  
Pulmonary Inflammation ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Invariant Nkt Cells

scholarly journals Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge

2018 ◽  
Author(s):  
Xiaoyan Zheng ◽  
Jennifer Dora Oduro ◽  
Julia Désirée Boehme ◽  
Lisa Borkner ◽  
Thomas Ebensen ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Cell Response ◽  
Influenza A ◽  
Clinical Medicine ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Vaccine Vector ◽  
Protective Capacity

Cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes life-long latent infection in a high percentage of the population worldwide. CMV induces the strongest and most durable CD8+ T cell response known in human clinical medicine. Due to its unique properties, the virus represents a promising candidate vaccine vector for the induction of persistent cellular immunity. To take advantage of this, we constructed a recombinant murine CMV (MCMV) expressing an MHC-I restricted epitope from influenza A virus (IAV) H1N1 within the immediate early 2 (ie2) gene. Only mice that were immunized intranasally (i.n.) were capable of controlling IAV infection, despite the greater potency of the intraperitoneally (i.p.) vaccination in inducing a systemic IAV-specific CD8+ T cell response. The protective capacity of the i.n. immunization was associated with its ability to induce IAV-specific tissue-resident memory CD8+ T (CD8TRM) cells in the lungs. Our data demonstrate that the protective effect exerted by the i.n. immunization was critically mediated by antigen-specific CD8+ T cells. CD8TRM cells promoted the induction of IFNγ and chemokines that facilitate the recruitment of antigen-specific CD8+ T cells to the lungs. Overall, our results showed that locally applied MCMV vectors could induce mucosal immunity at sites of entry, providing superior immune protection against respiratory infections.

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