scholarly journals Adolescent Social Isolation Does Not Lead to Persistent Increases in Anxiety- Like Behavior or Ethanol Intake in Female Long-Evans Rats

2014 ◽  
Vol 38 (8) ◽  
pp. 2199-2207 ◽  
Author(s):  
Tracy R. Butler ◽  
Eugenia Carter ◽  
Jeffrey L. Weiner
Keyword(s):  
Social Isolation ◽  
Ethanol Intake ◽  
Long Evans

A relation between maze performance and increased ethanol intake in Long–Evans rats

Alcohol ◽  
2002 ◽  
Vol 26 (2) ◽  
pp. 121-126 ◽  
Author(s):  
Lana M. Pratt ◽  
Shawn K.E. Gates ◽  
Brian R. Smith ◽  
Zalman Amit
Keyword(s):  
Ethanol Intake ◽  
Maze Performance ◽  
Long Evans

scholarly journals Baseline Lateral Habenula Firing Rate Negatively Correlates with Increase in Ethanol Intake over Days in Adult Long Evans Rats

2021 ◽  
Author(s):  
Shashank Tandon
Keyword(s):  
Affective State ◽  
Significant Negative Correlation ◽  
Individual Variability ◽  
Ethanol Intake ◽  
Drinking Patterns ◽  
Lateral Habenula ◽  
Firing Rates ◽  
Co Morbidity ◽  
Long Evans ◽  
First Session

AbstractWhile many adults consume alcohol, yet only some individuals are at a risk to develop alcohol use disorder (AUD). Variability in the risk for alcohol abuse is multifactorial and includes differences in behavioral and neuronal traits. The lateral habenula (LHb) has been shown to mediate aversive state-related behavioral responses. Interestingly, in both humans and rodents, depression-like symptoms are associated with high LHb activity. Additionally, there is a high co-morbidity between major depressive disorder and AUD. However, LHb lesions in rodents increase ethanol intake over time. Thus, we wanted to determine how baseline LHb activity correlates with ethanol intake over days. Specifically, we wanted to test whether individual variation in baseline LHb activity in ethanol-naive rats is related to home-cage ethanol drinking patterns. Hence, in this study, we determined the correlation between individual variability in baseline LHb neural activity, the negative-affective state-related ultrasonic vocalizations (USVs; 22-28 kHz), and the extent of ethanol intake over days. We first surgically implanted a unilateral 16-wire electrode array in the LHb of adult male Long Evans rats (n=11). Following recovery from surgery, rats were placed in sound-insulated chambers for two hours, where they were free to explore while we simultaneously recorded neuronal signals from their LHb and the USVs emitted by them. Next, these rats underwent an intermittent access to ethanol (IAE) paradigm, where they received 20% ethanol for 24 hours on alternate days (Monday-Wednesday-Friday) and ad-libitum water in their home cages for four weeks. The change in ethanol intake over days differed between rats, with some rats escalating their ethanol intake in the four weeks, while other rats showing no meaningful change in ethanol intake over days as compared to the first session. We found a significant negative correlation between average baseline LHb firing rates in rats and the changes in ethanol intake in the first week of IAE. Specifically, rats with higher baseline LHb firing rats, unlike rats with lower baseline firing rates, did not escalate their ethanol intake from the first session to the second and fourth ethanol sessions of the IAE paradigm. We also found a moderate positive correlation between the number of 22-28 kHz USVs and the average LHb firing rates of these rats. These results indicate that higher baseline LHb neuronal activity in normal adult ethanol naive rats is associated with decreased motivation to seek and consume ethanol during the early stages of ethanol consumption.

Analysis of CA Repeats in First Intron of Class I ADH Gene in Long-Evans Cinnamon Rats Developing Fatal Intoxication after Ethanol Intake

1996 ◽  
Vol 20 (s1) ◽  
pp. 33a-35a ◽  
Author(s):  
Shinichi Katsuki ◽  
Junji Kato ◽  
Masahiro Nakajima ◽  
Noriaki Inui ◽  
Katsunori Sasaki ◽  
...  
Keyword(s):  
Ethanol Intake ◽  
Class I ◽  
Fatal Intoxication ◽  
First Intron ◽  
Adh Gene ◽  
Long Evans

scholarly journals Social isolation–related depression accelerates ethanol intake via microglia-derived neuroinflammation

2021 ◽  
Vol 7 (45) ◽  
Author(s):  
Jin-Seok Lee ◽  
Sung-Bae Lee ◽  
Dong-Woon Kim ◽  
Nara Shin ◽  
Seon-Ju Jeong ◽  
...  
Keyword(s):  
Social Isolation ◽  
Ethanol Intake

Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

1982 ◽  
Vol 40 ◽  
pp. 216-217
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Microscopic Study ◽  
Pituitary Adenomas ◽  
Wistar Rats ◽  
Microscopic Level ◽  
Sprague Dawley ◽  
Prolactin Cells ◽  
Light Microscopic Level ◽  
Ultrastructural Investigation ◽  
Sprague Dawley Rats ◽  
Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

The effect of bromocriptine on mammary-gland ultrastructure of hyperprolactinemic rats

1984 ◽  
Vol 42 ◽  
pp. 204-205
Author(s):  
I.C. Murray
Keyword(s):  
Mammary Gland ◽  
Dopamine Agonist ◽  
Alveolar Epithelium ◽  
Mammary Glands ◽  
Female Rats ◽  
Control Group ◽  
Cell Hyperplasia ◽  
Once Daily ◽  
Long Evans

In women, hyperprolactinemia is often due to a prolactin (PRL)-secreting adenoma or PRL cell hyperplasia. RRL excess stimulates the mammary glands and causes proliferation of the alveolar epithelium. Bromocriptine, a dopamine agonist, inhibits PRL secretion and is given to women to treat nonpuerperal galactorrhea. Old female rats have been reported to have PRL cell hyperplasia or adenoma leading to PRL hypersecretion and breast stimulation. Herein, we describe the effect of bromocriptine and consequently the reduction in serum PRL levels on the ultrastructure of rat mammary glands.Female Long-Evans rats, 23 months of age, were divided into control and bromocriptine-treated groups. The control animals were injected subcutaneously once daily with a 10% ethanol vehicle and were later divided into a normoprolactinemic control group with serum PRL levels under 30 ng/ml and a hyperprolactinemic control group with serum PRL levels above 30 ng/ml.

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