scholarly journals Third Trimester-Equivalent Ethanol Exposure Does Not Alter Complex Spikes and Climbing Fiber Long-Term Depression in Cerebellar Purkinje Neurons from Juvenile Rats

2014 ◽  
Vol 38 (5) ◽  
pp. 1293-1300 ◽  
Author(s):  
Paula A. Zamudio-Bulcock ◽  
Russell A. Morton ◽  
C. Fernando Valenzuela
Keyword(s):  
Ethanol Exposure ◽  
Climbing Fiber ◽  
Purkinje Neurons ◽  
Third Trimester ◽  
Long Term Depression ◽  
Juvenile Rats ◽  
Cerebellar Purkinje Neurons ◽  
Complex Spikes

scholarly journals Long-term depression in Purkinje neurons is persistently impaired following cardiac arrest and cardiopulmonary resuscitation in mice

2016 ◽  
Vol 37 (8) ◽  
pp. 3053-3064 ◽  
Author(s):  
Nidia Quillinan ◽  
Guiying Deng ◽  
Kaori Shimizu ◽  
Ivelisse Cruz-Torres ◽  
Christian Schroeder ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiopulmonary Resuscitation ◽  
Motor Coordination ◽  
Purkinje Neurons ◽  
Long Term Depression ◽  
Initial Injury ◽  
Cerebellar Purkinje Neurons ◽  
Whole Cell Recordings ◽  
Time Point

Cardiac arrest and cardiopulmonary resuscitation (CA/CPR) produce brain ischemia that results in cognitive and motor coordination impairments subsequent to injury of vulnerable populations of neurons, including cerebellar Purkinje neurons. To determine the effects of CA/CPR on plasticity in the cerebellum, we used whole cell recordings from Purkinje neurons to examine long-term depression (LTD) at parallel fiber (PF) synapses. Acute slices were prepared from adult male mice subjected to 8 min cardiac arrest at 1, 7, and 30 days after resuscitation. Concurrent stimulation of PF and climbing fibers (CFs) resulted in robust LTD of PF-evoked excitatory postsynaptic currents (EPSCs) in controls. LTD was absent in recordings obtained from mice subjected to CA/CPR, with no change in EPSC amplitude from baseline at any time point tested. AMPA and mGluR-mediated responses at the PF were not altered by CA/CPR. In contrast, CF-evoked NMDA currents were reduced following CA/CPR, which could account for the loss of LTD observed. A loss of GluN1 protein was observed following CA/CPR that was surprisingly not associated with changes in mRNA expression. These data demonstrate sustained impairments in synaptic plasticity in Purkinje neurons that survive the initial injury and which likely contribute to motor coordination impairments observed after CA/CPR.

scholarly journals Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients

Neuron ◽  
1995 ◽  
Vol 15 (2) ◽  
pp. 407-415 ◽  
Author(s):  
Varda Lev-Ram ◽  
Lewis R. Makings ◽  
Paul F. Keitz ◽  
Joseph P.Y. Kao ◽  
Roger Y. Tsien
Keyword(s):  
Nitric Oxide ◽  
Purkinje Neurons ◽  
Long Term Depression ◽  
Cerebellar Purkinje Neurons

A long-term depression of AMPA currents in cultured cerebellar purkinje neurons

Neuron ◽  
1991 ◽  
Vol 7 (1) ◽  
pp. 81-89 ◽  
Author(s):  
David J. Linden ◽  
Michael H. Dickinson ◽  
Michelle Smeyne ◽  
John A. Connor
Keyword(s):  
Purkinje Neurons ◽  
Long Term Depression ◽  
Cerebellar Purkinje Neurons
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