scholarly journals Administration of Memantine During Withdrawal Mitigates Overactivity and Spatial Learning Impairments Associated with Neonatal Alcohol Exposure in Rats

2014 ◽  
Vol 38 (2) ◽  
pp. 529-537 ◽  
Author(s):  
Nirelia M. Idrus ◽  
Nancy N. H. McGough ◽  
Edward P. Riley ◽  
Jennifer D. Thomas
Keyword(s):  
Spatial Learning ◽  
Alcohol Exposure ◽  
Learning Impairments ◽  
Neonatal Alcohol Exposure

Intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevents the H-89-induced spatial learning deficits in Morris water maze

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mahmoud Hashemzaei ◽  
Najmeh Baratzadeh ◽  
Iraj Sharamian ◽  
Sahar Fanoudi ◽  
Mehdi Sanati ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Spatial Memory ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Synergistic Effects ◽  
Deionized Water ◽  
Learning Deficits ◽  
Learning Impairments ◽  
Morris Water Maze Task

Abstract Objectives H-89 (a protein kinase AII [PKA II] inhibitor) impairs the spatial memory in the Morris water maze task in rats. In the present study, we aimed to study the protective effects of nicotine and O-acetyl-L-carnitine against H-89-induced spatial memory deficits. Methods Spatial memory impairment was induced by the bilateral intrahippocampal administration of 10 µM H-89 (dissolved in dimethyl sulfoxide, DMSO) to rats. The rats then received bilateral administrations of either nicotine (1 μg/μL, dissolved in saline) or O-acetyl-L-carnitine (100 μM/side, dissolved in deionized water) alone and in combination. Control groups received either saline, deionized water, or DMSO. Results The H-89-treated animals showed significant increases in the time and distance travelled to find hidden platforms, and there was also a significant decrease in the time spent in the target quadrant compared to DMSO-treated animals. Nicotine and O-acetyl-L-carnitine had no significant effects on H-89-induced spatial learning impairments alone, but the bilateral intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevented H-89-induced spatial learning deficits and increased the time spent in the target quadrant in comparison with H-89-treated animals. Conclusions Our results indicated the potential synergistic effects of nicotine and O-acetyl-L-carnitine in preventing protein kinase AII inhibitor (H-89)-induced spatial learning impairments.

scholarly journals Effects of neonatal alcohol exposure on vasoactive intestinal polypeptide neurons in the rat suprachiasmatic nucleus

Alcohol ◽  
2009 ◽  
Vol 43 (5) ◽  
pp. 387-396 ◽  
Author(s):  
Yuhua Z. Farnell ◽  
Gregg C. Allen ◽  
Nichole Neuendorff ◽  
James R. West ◽  
A. Chen Wei-Jung ◽  
...  
Keyword(s):  
Suprachiasmatic Nucleus ◽  
Vasoactive Intestinal Polypeptide ◽  
Alcohol Exposure ◽  
Neonatal Alcohol Exposure ◽  
Intestinal Polypeptide

scholarly journals Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex.

2018 ◽  
Vol 132 (6) ◽  
pp. 497-511 ◽  
Author(s):  
Sarah A. Jablonski ◽  
Patrese A. Robinson-Drummer ◽  
William B. Schreiber ◽  
Arun Asok ◽  
Jeffrey B. Rosen ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Mrna Expression ◽  
Alcohol Exposure ◽  
Facilitation Effect ◽  
Juvenile Rats ◽  
Neonatal Alcohol Exposure

scholarly journals Neonatal Alcohol Exposure Induces Long-Lasting Impairment of Visual Cortical Plasticity in Ferrets

2003 ◽  
Vol 23 (31) ◽  
pp. 10002-10012 ◽  
Author(s):  
Alexandre E. Medina ◽  
Thomas E. Krahe ◽  
David M. Coppola ◽  
Ary S. Ramoa
Keyword(s):  
Cortical Plasticity ◽  
Alcohol Exposure ◽  
Neonatal Alcohol Exposure ◽  
Visual Cortical

Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats

2008 ◽  
Vol 448 (1) ◽  
pp. 110-114 ◽  
Author(s):  
Chun-Ai Cui ◽  
Da-Qing Jin ◽  
Yoo Kyeong Hwang ◽  
Im-Soon Lee ◽  
Jae Kwan Hwang ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Learning Impairments

Neonatal alcohol exposure increases malondialdehyde (MDA) and glutathione (GSH) levels in the developing cerebellum

2005 ◽  
Vol 160 (2) ◽  
pp. 231-238 ◽  
Author(s):  
Andrew M. Smith ◽  
Daniel R. Zeve ◽  
Jedidiah J. Grisel ◽  
Wei-Jung A. Chen
Keyword(s):  
Alcohol Exposure ◽  
Neonatal Alcohol Exposure ◽  
Developing Cerebellum

Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments

2007 ◽  
Vol 87 (1) ◽  
pp. 21-41 ◽  
Author(s):  
Corinna Burger ◽  
M. Cecilia López ◽  
Joyce A. Feller ◽  
Henry V. Baker ◽  
Nicholas Muzyczka ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Learning Impairments ◽  
Age Related
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