scholarly journals Binge-Pattern Ethanol Exposure During Adolescence, but Not Adulthood, Causes Persistent Changes in GABAAReceptor-Mediated Tonic Inhibition in Dentate Granule Cells

2013 ◽  
Vol 37 (7) ◽  
pp. 1154-1160 ◽  
Author(s):  
Rebekah L. Fleming ◽  
Qiang Li ◽  
Mary-Louise Risher ◽  
Hannah G. Sexton ◽  
Scott D. Moore ◽  
...  
Keyword(s):  
Granule Cells ◽  
Ethanol Exposure ◽  
Tonic Inhibition ◽  
Dentate Granule Cells

scholarly journals Sleep deprivation exacerbates seizures and diminishes GABAergic tonic inhibition

2021 ◽  
Author(s):  
Sai Surthi Konduru ◽  
Yuzhen Pan ◽  
Eli Wallace ◽  
Jesse A Pfammatter ◽  
Mathew V. Jones ◽  
...  
Keyword(s):  
Mouse Model ◽  
Sleep Deprivation ◽  
Voltage Clamp ◽  
Granule Cells ◽  
Basic Mechanism ◽  
Tonic Inhibition ◽  
Wild Type ◽  
Dentate Granule Cells ◽  
Patients With Epilepsy

AbstractPatients with epilepsy report that sleep deprivation is a common trigger for breakthrough seizures. The basic mechanism of this phenomenon is unknown. In the Kv1.1-/- mouse model of epilepsy, daily sleep deprivation indeed exacerbated seizures though these effects were lost after the 3rd day. Sleep deprivation also accelerated mortality in ~52% of Kv1.1-/- mice, not observed in controls. Voltage-clamp experiments on the day after recovery from sleep deprivation showed reductions in GABAergic tonic inhibition in dentate granule cells both in Kv1.1-/- and wild-type mice. Our results suggest that sleep deprivation is detrimental to seizures and survival, possibly due to reductions in GABAergic tonic inhibition.

Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury

2010 ◽  
Vol 38 (3) ◽  
pp. 464-475 ◽  
Author(s):  
Zakaria Mtchedlishvili ◽  
Eka Lepsveridze ◽  
Hong Xu ◽  
Elena A. Kharlamov ◽  
Bo Lu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Gabaa Receptor ◽  
Granule Cells ◽  
Tonic Inhibition ◽  
Dentate Granule Cells

scholarly journals Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Qingying Tang ◽  
Shuxia Chen ◽  
Hui Wu ◽  
Honghua Song ◽  
Yongjun Wang ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Granule Cells ◽  
Spine Density ◽  
Drug Induced ◽  
Distinct Cell Type ◽  
Cognitive Behaviors ◽  
Dentate Granule Cells ◽  
Rat Pups ◽  
Cognitive Deficiency ◽  
Underlying Mechanisms

AbstractCongenital hypothyroidism (CH), a common neonatal endocrine disorder, can result in cognitive deficits if delay in diagnose and treatment. Dentate gyrus (DG) is the severely affected subregion of the hippocampus by the CH, where the dentate granule cells (DGCs) reside in. However, how CH impairs the cognitive function via affecting DGCs and the underlying mechanisms are not fully elucidated. In the present study, the CH model of rat pups was successfully established, and the aberrant dendrite growth of the DGCs and the impaired cognitive behaviors were observed in the offspring. Transcriptome analysis of hippocampal tissues following rat CH successfully identified that calcium/calmodulin-dependent protein kinase IV (CaMKIV) was the prominent regulator involved in mediating deficient growth of DGC dendrites. CaMKIV was shown to be dynamically regulated in the DG subregion of the rats following drug-induced CH. Interference of CaMKIV expression in the primary DGCs significantly reduced the spine density of dendrites, while addition of T3 to the primary DGCs isolated from CH pups could facilitate the spine growth of dendrites. Insights into relevant mechanisms revealed that CH-mediated CaMKIV deficiency resulted in the significant decrease of phosphorylated CREB in DGCs, in association with the abnormality of dendrites. Our results have provided a distinct cell type in hippocampus that is affected by CH, which would be beneficial for the treatment of CH-induced cognitive deficiency.

scholarly journals Pten Knockdown In Vivo Increases Excitatory Drive onto Dentate Granule Cells

2011 ◽  
Vol 31 (11) ◽  
pp. 4345-4354 ◽  
Author(s):  
B. W. Luikart ◽  
E. Schnell ◽  
E. K. Washburn ◽  
A. L. Bensen ◽  
K. R. Tovar ◽  
...  
Keyword(s):  
Granule Cells ◽  
Dentate Granule Cells ◽  
Excitatory Drive
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