scholarly journals The Declining Efficacy of Naltrexone Pharmacotherapy for Alcohol Use Disorders Over Time: A Multivariate Meta-Analysis

2013 ◽  
Vol 37 (6) ◽  
pp. 1064-1068 ◽  
Author(s):  
A. C. Del Re ◽  
Natalya Maisel ◽  
Janet Blodgett ◽  
John Finney
Keyword(s):  
Alcohol Use ◽  
Meta Analysis ◽  
Alcohol Use Disorders ◽  
Over Time

Prevalence of alcohol use disorders in schizophrenia - a systematic review and meta-analysis

2009 ◽  
Vol 120 (2) ◽  
pp. 85-96 ◽  
Author(s):  
J. Koskinen ◽  
J. Löhönen ◽  
H. Koponen ◽  
M. Isohanni ◽  
J. Miettunen
Keyword(s):  
Systematic Review ◽  
Alcohol Use ◽  
Meta Analysis ◽  
Alcohol Use Disorders

Predictors of Alcohol Use Disorders Among Baby Boomers Across the Life Course

2018 ◽  
Vol 39 (8) ◽  
pp. 880-888
Author(s):  
Adam Quinn ◽  
Orion Mowbray
Keyword(s):  
Alcohol Use ◽  
Life Course ◽  
Baby Boomers ◽  
Alcohol Use Disorders ◽  
Life Course Perspective ◽  
Future Research ◽  
Older Adulthood ◽  
Use Patterns ◽  
The Life Course ◽  
Over Time

Research suggests that baby boomers entering older adulthood may possess unique alcohol use patterns over time. Using the life course perspective as a guiding framework, this empirical study sought to examine correlates of alcohol use disorders among baby boomers by examining representative data from the National Survey on Drug Use and Health at two points in time, 1998 ( N = 6,213) and 2010 ( N = 5,880). Results from logistic regression analyses suggest that predictors of alcohol use disorders evolve over time as baby boomers continue to age. Risk factors for alcohol use disorders among baby boomers may include concurrent unprescribed pain reliever use, p < .01, while protective factors such as income, p < .01, and social supports, p = .01, may be of increased importance. Based on the findings of this study, practice implications and future research are discussed.

Treatment rates for alcohol use disorders: a systematic review and meta‐analysis

Addiction ◽  
2020 ◽  
Author(s):  
Tesfa Mekonen ◽  
Gary C. K. Chan ◽  
Jason Connor ◽  
Wayne Hall ◽  
Leanne Hides ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alcohol Use ◽  
Meta Analysis ◽  
Alcohol Use Disorders

scholarly journals Efficacy of pharmacotherapeutics for patients comorbid with alcohol use disorders and depressive symptoms—A bayesian network meta‐analysis

2020 ◽  
Vol 26 (11) ◽  
pp. 1185-1197
Author(s):  
Jiande Li ◽  
Hongxuan Wang ◽  
Mei Li ◽  
Qingyu Shen ◽  
Xiangpen Li ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Alcohol Use ◽  
Bayesian Network ◽  
Meta Analysis ◽  
Alcohol Use Disorders

scholarly journals Posttraumatic psychopathology and the pace of the epigenetic clock: a longitudinal investigation

2018 ◽  
Vol 49 (5) ◽  
pp. 791-800 ◽  
Author(s):  
Erika J. Wolf ◽  
Mark W. Logue ◽  
Filomene G. Morrison ◽  
Elizabeth S. Wilcox ◽  
Annjanette Stone ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Alcohol Use ◽  
Psychiatric Symptoms ◽  
Alcohol Use Disorders ◽  
Cellular Aging ◽  
Epigenetic Clock ◽  
Afghanistan War ◽  
Genome Wide ◽  
Dna Methylation Age ◽  
Over Time

AbstractBackgroundPosttraumatic stress disorder (PTSD) and stress/trauma exposure are cross-sectionally associated with advanced DNA methylation age relative to chronological age. However, longitudinal inquiry and examination of associations between advanced DNA methylation age and a broader range of psychiatric disorders is lacking. The aim of this study was to examine if PTSD, depression, generalized anxiety, and alcohol-use disorders predicted acceleration of DNA methylation age over time (i.e. an increasing pace, or rate of advancement, of the epigenetic clock).MethodsGenome-wide DNA methylation and a comprehensive set of psychiatric symptoms and diagnoses were assessed in 179 Iraq/Afghanistan war veterans who completed two assessments over the course of approximately 2 years. Two DNA methylation age indices (Horvath and Hannum), each a weighted index of an array of genome-wide DNA methylation probes, were quantified. The pace of the epigenetic clock was operationalized as change in DNA methylation age as a function of time between assessments.ResultsAnalyses revealed that alcohol-use disorders (p = 0.001) and PTSD avoidance and numbing symptoms (p = 0.02) at Time 1 were associated with an increasing pace of the epigenetic clock over time, per the Horvath (but not the Hannum) index of cellular aging.ConclusionsThis is the first study to suggest that posttraumatic psychopathology is longitudinally associated with a quickened pace of the epigenetic clock. Results raise the possibility that accelerated cellular aging is a common biological consequence of stress-related psychopathology, which carries implications for identifying mechanisms of stress-related cellular aging and developing interventions to slow its pace.

Externalizing and internalizing symptoms in childhood and adolescence and the risk of alcohol use disorders in young adulthood: A meta-analysis of longitudinal studies

2019 ◽  
Vol 53 (10) ◽  
pp. 965-975 ◽  
Author(s):  
Ivete Meque ◽  
Berihun Assefa Dachew ◽  
Joemer C Maravilla ◽  
Caroline Salom ◽  
Rosa Alati
Keyword(s):  
Alcohol Use ◽  
Young Adulthood ◽  
Odds Ratio ◽  
Internalizing Symptoms ◽  
Meta Analysis ◽  
Alcohol Use Disorders ◽  
Childhood And Adolescence ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Externalizing And Internalizing Symptoms

Background: Evidence suggests that externalizing and internalizing symptoms are expressed early in life and are associated with problematic drinking in young adulthood. However, few studies have examined their role during childhood and adolescence in predicting alcohol problems later in life. Objectives: To examine the role of childhood and adolescent externalizing and internalizing symptoms in predicting alcohol use disorders in young adulthood. Methods: We searched five electronic databases (PubMed, Scopus, PsycINFO, Web of Sciences and Embase) for studies which diagnosed alcohol use disorders through either the International Classification of Diseases or American Psychiatric Association – Diagnostic and Statistical Manual of Mental Disorders criteria and followed up children or adolescents into the transition to young adulthood. We performed a meta-analysis and obtained pooled odds ratio estimates with 95% confidence intervals using random-effects models. Results: A total of 12 longitudinal studies met eligibility criteria and were included in the meta-analysis. All measured the outcome using Diagnostic and Statistical Manual of Mental Disorders criteria. The majority were of good quality and were conducted in the United States. A total of 19,407 participants (50% female) were included in this meta-analysis. Of these, n = 2337 (12%) had diagnoses of alcohol use disorders/alcohol dependence. Participant ages ranged from birth to 36 years. Internalizing symptoms increased the risk of young adult alcohol use disorders by 21% (odds ratio = 1.21; 95% confidence interval = [1.05, 1.39]), with no strong evidence of publication bias. Subgroup analysis suggested significantly lower heterogeneity than for externalizing studies. Externalizing symptoms increased the risk of alcohol use disorders by 62% (odds ratio = 1.62, 95% confidence interval = [1.39, 1.90]). We found some evidence of publication bias and significant heterogeneity in the studies. Conclusion: Our findings highlight the contribution of early behavioural problems to the development of alcohol use disorders in young adulthood and the need for timely scrutiny of and intervention on early behavioural problems.

Genetic polymorphisms and response to medications for alcohol use disorders: a systematic review and meta-analysis

2014 ◽  
Vol 15 (13) ◽  
pp. 1687-1700 ◽  
Author(s):  
Daniel E Jonas ◽  
Halle R Amick ◽  
Cynthia Feltner ◽  
Roberta Wines ◽  
Ellen Shanahan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alcohol Use ◽  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Alcohol Use Disorders
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