scholarly journals Downregulation of ROR2 promotes dental pulp stem cell senescence by inhibiting STK4‐FOXO1/SMS1 axis in sphingomyelin biosynthesis

Aging Cell ◽  
2021 ◽  
Author(s):  
Xing‐yue Dong ◽  
Yan‐xia Huang ◽  
Zhan Yang ◽  
Xiao‐yang Chu ◽  
Jue Wu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dental Pulp ◽  
Cell Senescence ◽  
Dental Pulp Stem Cell

scholarly journals miR-152 induces human dental pulp stem cell senescence by inhibiting SIRT7 expression

FEBS Letters ◽  
2016 ◽  
Vol 590 (8) ◽  
pp. 1123-1131 ◽  
Author(s):  
Shensheng Gu ◽  
Shujun Ran ◽  
Bin Liu ◽  
Jingping Liang
Keyword(s):  
Stem Cell ◽  
Dental Pulp ◽  
Cell Senescence ◽  
Human Dental Pulp ◽  
Dental Pulp Stem Cell

scholarly journals Alginate/Pluronic F127-based encapsulation supports viability and functionality of human dental pulp stem cell-derived insulin-producing cells

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Suryo Kuncorojakti ◽  
Watchareewan Rodprasert ◽  
Supansa Yodmuang ◽  
Thanaphum Osathanon ◽  
Prasit Pavasant ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dental Pulp ◽  
Pluronic F127 ◽  
Insulin Producing Cells ◽  
Human Dental Pulp ◽  
Dental Pulp Stem Cell

Effects of Restorative Materials on Dental Pulp Stem Cell Properties

2019 ◽  
Vol 45 (4) ◽  
pp. 420-426 ◽  
Author(s):  
Chao-An Chen ◽  
Yuh-Ling Chen ◽  
Jehn-Shyun Huang ◽  
George T.-J. Huang ◽  
Shu-Fen Chuang
Keyword(s):  
Stem Cell ◽  
Dental Pulp ◽  
Restorative Materials ◽  
Dental Pulp Stem Cell

scholarly journals Electrical Stimulation Decreases Dental Pulp Stem Cell Osteo-/Odontogenic Differentiation

2020 ◽  
Vol 9 (1) ◽  
pp. 162-173
Author(s):  
Karla Mychellyne Costa Oliveira ◽  
Liudmila Leppik ◽  
Khyati Keswani ◽  
Sreeraj Rajeev ◽  
Mit B. Bhavsar ◽  
...  
Keyword(s):  
Stem Cell ◽  
Electrical Stimulation ◽  
Dental Pulp ◽  
Odontogenic Differentiation ◽  
Dental Pulp Stem Cell

scholarly journals Macrophage modulation of dental pulp stem cell activity during tertiary dentinogenesis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Vitor C. M. Neves ◽  
Val Yianni ◽  
Paul T. Sharpe
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Immune Cells ◽  
Dental Pulp ◽  
Cell Activation ◽  
Cell Activity ◽  
Stem Cell Differentiation ◽  
Dental Pulp Stem Cell ◽  
Anti Inflammatory

AbstractThe interaction between immune cells and stem cells is important during tissue repair. Macrophages have been described as being crucial for limb regeneration and in certain circumstances have been shown to affect stem cell differentiation in vivo. Dentine is susceptible to damage as a result of caries, pulp infection and inflammation all of which are major problems in tooth restoration. Characterising the interplay between immune cells and stem cells is crucial to understand how to improve natural repair mechanisms. In this study, we used an in vivo damage model, associated with a macrophage and neutrophil depletion model to investigate the role of immune cells in reparative dentine formation. In addition, we investigated the effect of elevating the Wnt/β-catenin pathway to understand how this might regulate macrophages and impact upon Wnt receiving pulp stem cells during repair. Our results show that macrophages are required for dental pulp stem cell activation and appropriate reparative dentine formation. In addition, pharmacological stimulation of the Wnt/β-catenin pathway via GSK-3β inhibitor small molecules polarises macrophages to an anti-inflammatory state faster than inert calcium silicate-based materials thereby accelerating stem cell activation and repair. Wnt/β-catenin signalling thus has a dual role in promoting reparative dentine formation by activating pulp stem cells and promoting an anti-inflammatory macrophage response.

scholarly journals Functionalized Scaffolds to Control Dental Pulp Stem Cell Fate

2014 ◽  
Vol 40 (4) ◽  
pp. S33-S40 ◽  
Author(s):  
Evandro Piva ◽  
Adriana F. Silva ◽  
Jacques E. Nör
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Dental Pulp ◽  
Stem Cell Fate ◽  
Dental Pulp Stem Cell
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