scholarly journals AMPK‐mediated formation of stress granules is required for dietary restriction‐induced longevity in Caenorhabditis elegans

Aging Cell ◽  
2020 ◽  
Vol 19 (6) ◽  
Author(s):  
Chen‐Ting Kuo ◽  
Guan‐Ting You ◽  
Ying‐Jie Jian ◽  
Ting‐Shin Chen ◽  
Yu‐Chen Siao ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Dietary Restriction ◽  
Stress Granules

scholarly journals Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

Aging Cell ◽  
2010 ◽  
Vol 10 (1) ◽  
pp. 39-54 ◽  
Author(s):  
Laurent Mouchiroud ◽  
Laurent Molin ◽  
Prasad Kasturi ◽  
Mohamed N. Triba ◽  
Marc Emmanuel Dumas ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Dietary Restriction ◽  
Metabolic Reprogramming ◽  
Lifespan Extension

scholarly journals Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans

2021 ◽  
Vol 288 (1950) ◽  
Author(s):  
Edward R. Ivimey-Cook ◽  
Kris Sales ◽  
Hanne Carlsson ◽  
Simone Immler ◽  
Tracey Chapman ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Dietary Restriction ◽  
Mortality Risk ◽  
Lifespan Extension ◽  
Dietary Interventions ◽  
Negative Effects ◽  
Trade Offs ◽  
Wide Range ◽  
Broad Variety

Dietary restriction (DR) increases lifespan in a broad variety of organisms and improves health in humans. However, long-term transgenerational consequences of dietary interventions are poorly understood. Here, we investigated the effect of DR by temporary fasting (TF) on mortality risk, age-specific reproduction and fitness across three generations of descendants in Caenorhabditis elegans . We show that while TF robustly reduces mortality risk and improves late-life reproduction of the individuals subject to TF (P 0 ), it has a wide range of both positive and negative effects on their descendants (F 1 –F 3 ). Remarkably, great-grandparental exposure to TF in early life reduces fitness and increases mortality risk of F 3 descendants to such an extent that TF no longer promotes a lifespan extension. These findings reveal that transgenerational trade-offs accompany the instant benefits of DR, underscoring the need to consider fitness of future generations in pursuit of healthy ageing.

The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans

2011 ◽  
Vol 406 (3) ◽  
pp. 478-482 ◽  
Author(s):  
Juan Carlos Fierro-González ◽  
María González-Barrios ◽  
Antonio Miranda-Vizuete ◽  
Peter Swoboda
Keyword(s):  
Caenorhabditis Elegans ◽  
Dietary Restriction ◽  
Lifespan Extension ◽  
Adult Lifespan

scholarly journals Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans

Aging Cell ◽  
2008 ◽  
Vol 7 (3) ◽  
pp. 394-404 ◽  
Author(s):  
Katherine A. Steinkraus ◽  
Erica D. Smith ◽  
Christina Davis ◽  
Daniel Carr ◽  
William R. Pendergrass ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Dietary Restriction ◽  
Dependent Mechanism

scholarly journals Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans

Lab on a Chip ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 120-135 ◽  
Author(s):  
Huseyin Baris Atakan ◽  
Matteo Cornaglia ◽  
Laurent Mouchiroud ◽  
Johan Auwerx ◽  
Martin A. M. Gijs
Keyword(s):  
Caenorhabditis Elegans ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Dietary Restriction ◽  
Larval Stage ◽  
Disease Development ◽  
Nematode Caenorhabditis Elegans

We performed automated high-content phenotyping of Caenorhabditis elegans and demonstrated that dietary restriction slows down Huntington's disease development.

scholarly journals CBP-1 Acts in GABAergic Neurons to Double Life Span in Axenically Cultured Caenorhabditis elegans

2017 ◽  
Vol 74 (8) ◽  
pp. 1198-1205 ◽  
Author(s):  
Huaihan Cai ◽  
Ineke Dhondt ◽  
Lieselot Vandemeulebroucke ◽  
Caroline Vlaeminck ◽  
Madina Rasulova ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Life Span ◽  
Dietary Restriction ◽  
Gabaergic Neurons ◽  
Creb Binding Protein ◽  
Axenic Medium ◽  
Life Span Extension ◽  
Gene Functions ◽  
Key Genes

Abstract When cultured in axenic medium, Caenorhabditis elegans shows the largest life-span extension compared with other dietary restriction regimens. However, the underlying molecular mechanism still remains elusive. The gene cbp-1, encoding the worm ortholog of p300/CBP (CREB-binding protein), is one of the very few key genes known to be essential for life span doubling under axenic dietary restriction (ADR). By using tissue-specific RNAi, we found that cbp-1 expression in the germline is essential for fertility, whereas this gene functions specifically in the GABAergic neurons to support the full life span–doubling effect of ADR. Surprisingly, GABA itself is not required for ADR-induced longevity, suggesting a role of neuropeptide signaling. In addition, chemotaxis assays illustrate that neuronal inactivation of CBP-1 affects the animals’ food sensing behavior. Together, our results show that the strong life-span extension in axenic medium is under strict control of GABAergic neurons and may be linked to food sensing.

scholarly journals Paternal dietary restriction affects progeny fat content in Caenorhabditis elegans

IUBMB Life ◽  
2012 ◽  
Vol 64 (7) ◽  
pp. 644-648 ◽  
Author(s):  
Claudia Miersch ◽  
Frank Döring
Keyword(s):  
Caenorhabditis Elegans ◽  
Dietary Restriction ◽  
Fat Content

scholarly journals Lamin regulates the dietary restriction response via the mTOR pathway in Caenorhabditis elegans

2021 ◽  
Author(s):  
Chayki Charar ◽  
Sally Metsuyanim-Cohen ◽  
Daniel Z. Bar
Keyword(s):  
Body Size ◽  
Caenorhabditis Elegans ◽  
Life Span ◽  
Dietary Restriction ◽  
Metabolic Regulation ◽  
Fat Content ◽  
Mtor Pathway ◽  
Reduced Body ◽  
Animal Size ◽  
Mtor Complex 1

Animals subjected to dietary restriction (DR) have reduced body size, low fecundity, slower development, lower fat content and longer life span. We identified lamin as a regulator of multiple dietary restriction phenotypes. Downregulation of lmn-1, the single Caenorhabditis elegans lamin gene, increased animal size and fat content, specifically in DR animals. The LMN-1 protein acts in the mTOR pathway, upstream to RAPTOR and S6K, key component and target of mTOR complex 1 (mTORC1), respectively. DR excludes the mTORC1 activator RAGC-1 from the nucleus. Downregulation of lmn-1 restores RAGC-1 to the nucleus, a necessary step for the activation of the mTOR pathway. These findings further link lamin to metabolic regulation.

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