scholarly journals Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

Aging Cell ◽  
2019 ◽  
Vol 19 (2) ◽  
Author(s):  
Lorena Raquel Rocha ◽  
Viet Anh Nguyen Huu ◽  
Claudia Palomino La Torre ◽  
Qianlan Xu ◽  
Mary Jabari ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Early Removal

scholarly journals Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

2019 ◽  
Author(s):  
Lorena Raquel Rocha ◽  
Viet Anh Nguyen Huu ◽  
Claudia Palomino La Torre ◽  
Qianlan Xu ◽  
Mary Jabari ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Retinal Ganglion Cells ◽  
Visual Evoked Potential ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Early Removal ◽  
Transcriptional Changes ◽  
Secretory Phenotype ◽  
Iop Elevation ◽  
Retinal Functions

AbstractExperimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimicks events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset of genes that encode multiple proteins collectively referred to as the senescence-associated secretory phenotype (SASP). Emerging evidence suggests that the presence of these proinflammatory and matrix-degrading molecules has deleterious effects in a variety of tissues. In the current study, we demonstrated in a transgenic mouse model that early removal of senescent cells induced upon elevated intraocular pressure (IOP) protects unaffected RGCs from senescence and apoptosis. Visual evoked potential (VEP) analysis demonstrated that remaining RGCs are functional and that the treatment protected visual functions. Finally, removal of endogenous senescent retinal cells after IOP elevation by a treatment with senolytic drug dasatinib prevented loss of retinal functions and cellular structure. Senolytic drugs may have the potential to mitigate the deleterious impact of elevated IOP on RGC survival in glaucoma and other optic neuropathies.

scholarly journals The effect of celastrol on the ocular hypertension-induced degeneration of retinal ganglion cells

2018 ◽  
Vol 670 ◽  
pp. 89-93 ◽  
Author(s):  
Lei Gu ◽  
Jacky M.K. Kwong ◽  
Daniel Yadegari ◽  
Fei Yu ◽  
Joseph Caprioli ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion

CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway

2004 ◽  
Vol 19 (2) ◽  
pp. 265-272 ◽  
Author(s):  
Jian-Zhong Ji ◽  
Wassim Elyaman ◽  
Henry K. Yip ◽  
Vincent W. H. Lee ◽  
Leung-Wah Yick ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Stat3 Pathway
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