scholarly journals Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-223 expressions: a study on postmenopausal monozygotic twin pairs

Aging Cell ◽  
2014 ◽  
Vol 13 (5) ◽  
pp. 850-861 ◽  
Author(s):  
Fabiola Olivieri ◽  
Maarit Ahtiainen ◽  
Raffaella Lazzarini ◽  
Eija Pöllänen ◽  
Miriam Capri ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Monozygotic Twin

The Effect Of Hormone Replacement Therapy On Skeletal Muscle Attenuation In Early Postmenopausal Women

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S277
Author(s):  
Dennis R. Taaffe ◽  
Sarianna Sipil?? ◽  
Sulin Cheng ◽  
Jukka Puolakka ◽  
Jarmo Toivanen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Hormone Replacement ◽  
Early Postmenopausal Women ◽  
Muscle Attenuation

scholarly journals Leukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy

2017 ◽  
Vol 20 (2) ◽  
pp. 119-131 ◽  
Author(s):  
Elina Sillanpää ◽  
Paula Niskala ◽  
Eija K. Laakkonen ◽  
Elodie Ponsot ◽  
Markku Alén ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Hormone Replacement Therapy ◽  
Telomere Length ◽  
Hormone Replacement ◽  
Monozygotic Twin ◽  
Fat Free Mass ◽  
Thigh Muscle ◽  
Muscle Area

Estrogen-based hormone replacement therapy (HRT) may be associated with deceleration of cellular aging. We investigated whether long-term HRT has effects on leukocyte (LTL) or mean and minimum skeletal muscle telomere length (SMTL) in a design that controls for genotype and childhood environment. Associations between telomeres, body composition, and physical performance were also examined. Eleven monozygotic twin pairs (age 57.6 ± 1.8 years) discordant for HRT were studied. Mean duration of HRT use was 7.3 ± 3.7 years in the user sister, while their co-twins had never used HRT. LTL was measured by qPCR and SMTLs by southern blot. Body and muscle composition were estimated by bioimpedance and computed tomography, respectively. Physical performance was measured by jumping height and grip strength. HRT users and non-users did not differ in LTL or mean or minimum SMTL. Within-pair correlations were high in LTL (r= 0.69,p= .020) and in mean (r= 0.74,p= .014) and minimum SMTL (r= 0.88,p= .001). Body composition and performance were better in users than non-users. In analyses of individuals, LTL was associated with BMI (r2= 0.30,p= .030), percentage total body (r2= 0.43,p= .014), and thigh (r2= 0.55,p= .004) fat, while minimum SMTL was associated with fat-free mass (r2= 0.27,p= .020) and thigh muscle area (r2= 0.42,p= .016). We found no associations between HRT use and telomere length. Longer LTLs were associated with lower total and regional fat, while longer minimum SMTLs were associated with higher fat-free mass and greater thigh muscle area. This suggests that telomeres measured from different tissues may have different associations with measures of body composition.

scholarly journals Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle

2010 ◽  
Vol 20 (5) ◽  
pp. 372-379 ◽  
Author(s):  
Eija Pöllänen ◽  
Paula H.A. Ronkainen ◽  
Mia Horttanainen ◽  
Timo Takala ◽  
Jukka Puolakka ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement

scholarly journals The Effect Of Hormone Replacement Therapy On Skeletal Muscle Attenuation In Early Postmenopausal Women

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S277
Author(s):  
Dennis R. Taaffe ◽  
Sarianna Sipilä ◽  
Sulin Cheng ◽  
Jukka Puolakka ◽  
Jarmo Toivanen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Hormone Replacement ◽  
Early Postmenopausal Women ◽  
Muscle Attenuation

scholarly journals OGT and OGA expression in postmenopausal skeletal muscle associates with hormone replacement therapy and muscle cross-sectional area

2013 ◽  
Vol 48 (12) ◽  
pp. 1501-1504 ◽  
Author(s):  
Minna H.M. Toivonen ◽  
Eija Pöllänen ◽  
Maarit Ahtiainen ◽  
Harri Suominen ◽  
Dennis R. Taaffe ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Muscle Cross Sectional Area
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