scholarly journals Handling Oxygenation Targets in the Intensive Care Unit (HOT‐ICU)—Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure

2019 ◽  
Author(s):  
Olav L. Schjørring ◽  
Anders Perner ◽  
Jørn Wetterslev ◽  
Theis Lange ◽  
Frederik Keus ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Respiratory Failure ◽  
Randomised Clinical Trial

scholarly journals The effect of using Richmond agitation and sedation scale on hospital stay, ventilator dependence, and mortality rate in ICU inpatients: a randomised clinical trial

2020 ◽  
Vol 25 (8) ◽  
pp. 734-746
Author(s):  
Mahbobeh Rashidi ◽  
Shahram Molavynejad ◽  
Nasser Javadi ◽  
Mohammad Adineh ◽  
Assad Sharhani ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Glasgow Coma Scale ◽  
Hospital Stay ◽  
Glasgow Coma Scale Score ◽  
Randomised Clinical Trial ◽  
Sedation Scale ◽  
Coma Scale ◽  
Hospital Stay Duration

Background Managing the amount of use of sedatives due to their high side effects in the intensive care unit is essential. Sedation-agitation protocols may play an important role in this regard. However, they have not been practically applied in Iran. Aims This study aimed to evaluate the effect of using the Richmond agitation and sedation scale on hospital stay duration and dependency rate on the intensive care unit ventilator system in Ahwaz City, Iran, in 2016–2017. Methods This randomised clinical trial was conducted on 74 patients. The subjects were selected by a stratified sampling method and divided into the experimental ( n = 32) and control ( n = 32) groups. Sedation and agitation levels were managed by the Richmond agitation and sedation scale as soon as the samples were anxious and agitated, and every 6 hours in the intervention group. However, the control group received routine care. The data obtained were analysed by the Statistical Package for the Social Sciences (SPSS). Results There was no significant difference between the two groups in terms of demographic variables, such as age, gender, admission diagnosis and Glasgow coma scale scores on admission. However, they differed in terms of hospital stay duration and ventilator connection ( P < 0.001), Glasgow coma scale score at the separation time from the device ( P < 0.001), Glasgow coma scale score at the discharge time from the intensive care unit ( P < 0.02) and intensive care unit death rate ( P < 0.001). In all cases mentioned previously, the intervention group’s condition was better. Conclusions Based on the results of this study, as well as the approval of validation and reliability of the Richmond agitation and sedation scale in different studies, this protocol can be very effective in optimising the use of sedatives in the intensive care unit.

Scandinavian glutamine trial: a pragmatic multi-centre randomised clinical trial of intensive care unit patients

2011 ◽  
Vol 55 (7) ◽  
pp. 812-818 ◽  
Author(s):  
J. WERNERMAN ◽  
T. KIRKETEIG ◽  
B. ANDERSSON ◽  
H. BERTHELSON ◽  
A. ERSSON ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Randomised Clinical Trial

scholarly journals Is it necessary to have a dentist within an intensive care unit team? Report of a randomised clinical trial

2018 ◽  
Vol 68 (6) ◽  
pp. 420-427 ◽  
Author(s):  
Wanessa Teixeira Bellissimo-Rodrigues ◽  
Mayra Gonçalves Menegueti ◽  
Gilberto Gambero Gaspar ◽  
Hayala Cristina Cavenague de Souza ◽  
Maria Auxiliadora-Martins ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Randomised Clinical Trial ◽  
Intensive Care Unit Team

scholarly journals Higher Acid-Base Imbalance Associated with Respiratory Failure Could Decrease the Survival of Patients with Scrub Typhus during Intensive Care Unit Stay: A Gene Set Enrichment Analysis

2019 ◽  
Vol 8 (10) ◽  
pp. 1580 ◽  
Author(s):  
Kyoung Min Moon ◽  
Kyueng-Whan Min ◽  
Mi-Hye Kim ◽  
Dong-Hoon Kim ◽  
Byoung Kwan Son ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Respiratory Failure ◽  
Scrub Typhus ◽  
Enrichment Analysis ◽  
Gene Set Enrichment Analysis ◽  
Acid Base ◽  
Gene Set Enrichment ◽  
Gene Set ◽  
Gene Sets

Ninety percent of patients with scrub typhus (SC) with vasculitis-like syndrome recover after mild symptoms; however, 10% can suffer serious complications, such as acute respiratory failure (ARF) and admission to the intensive care unit (ICU). Predictors for the progression of SC have not yet been established, and conventional scoring systems for ICU patients are insufficient to predict severity. We aimed to identify simple and robust indicators to predict aggressive behaviors of SC. We evaluated 91 patients with SC and 81 non-SC patients who were admitted to the ICU, and 32 cases from the public functional genomics data repository for gene expression analysis. We analyzed the relationships between several predictors and clinicopathological characteristics in patients with SC. We performed gene set enrichment analysis (GSEA) to identify SC-specific gene sets. The acid-base imbalance (ABI), measured 24 h before serious complications, was higher in patients with SC than in non-SC patients. A high ABI was associated with an increased incidence of ARF, leading to mechanical ventilation and worse survival. GSEA revealed that SC correlated to gene sets reflecting inflammation/apoptotic response and airway inflammation. ABI can be used to indicate ARF in patients with SC and assist with early detection.

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