Severe vitamin D deficiency is common in critically ill patients at a high northern latitude

2016 ◽  
Vol 60 (9) ◽  
pp. 1289-1296 ◽  
Author(s):  
R. B. Kvaran ◽  
M. I. Sigurdsson ◽  
S. J. Skarphedinsdottir ◽  
G. H. Sigurdsson
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
High Northern Latitude ◽  
Severe Vitamin ◽  
Northern Latitude

scholarly journals Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled double-blind phase III RCT (the VITDALIZE study)

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e031083 ◽  
Author(s):  
Karin Amrein ◽  
Dhruv Parekh ◽  
Sabine Westphal ◽  
Jean-Charles Preiser ◽  
Andrea Berghold ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
University Hospital ◽  
Phase Iii ◽  
High Dose ◽  
Double Blind ◽  
Severe Vitamin ◽  
Increased Risk

IntroductionObservational studies have demonstrated an association between vitamin D deficiency and increased risk of morbidity and mortality in critically ill patients. Cohort studies and pilot trials have suggested promising beneficial effects of vitamin D replacement in the critical ill, at least in patients with severe vitamin D deficiency. As vitamin D is a simple, low-cost and safe intervention, it has potential to improve survival in critically ill patients.Methods and analysisIn this randomised, placebo-controlled, double-blind, multicentre, international trial, 2400 adult patients with severe vitamin D deficiency (25-hydroxyvitamin D≤12 ng/mL) will be randomised in a 1:1 ratio by www.randomizer.at to receive a loading dose of 540 000 IU cholecalciferol within 72 hours after intensive care unit (ICU) admission, followed by 4000 IU daily for 90 days or placebo. Hypercalcaemia may occur as a side effect, but is monitored by regular checks of the calcium level. The primary outcome is all-cause mortality at 28 days after randomisation. Secondary outcomes are: ICU, hospital, 90-day and 1-year mortality; hospital and ICU length of stay, change in organ dysfunction on day 5 as measured by Sequential Organ Function Assessment (SOFA) score, number of organ failures; hospital and ICU readmission until day 90; discharge destination, self-reported infections requiring antibiotics until day 90 and health-related quality of life. Recruitment status is ongoing.Ethics and disseminationNational ethical approval was obtained by the Ethics Committee of the University of Graz for Austria, Erasme University Brussels (Belgium) and University Hospital Frankfurt (Germany), and will further be gained according to individual national processes. On completion, results will be published in a peer-reviewed scientific journal. The study findings will be presented at national and international meetings with abstracts online.Trial registrationNCT03188796, EudraCT-No: 2016-002460-13.

Relationship of Vitamin D Deficiency to Clinical Outcomes in Critically Ill Patients

2012 ◽  
Vol 36 (6) ◽  
pp. 713-720 ◽  
Author(s):  
David M. Higgins ◽  
Paul E. Wischmeyer ◽  
Kelly M. Queensland ◽  
Stefan H. Sillau ◽  
Alexandra J. Sufit ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Relationship Of

scholarly journals Vitamin D deficiency in critically ill patients with traumatic injuries

2016 ◽  
Vol 4 ◽  
pp. 1-9 ◽  
Author(s):  
Roland N. Dickerson ◽  
Jonathan R. Van Cleve ◽  
Joseph M. Swanson ◽  
George O. Maish ◽  
Gayle Minard ◽  
...  
Keyword(s):  
Vitamin D ◽  
African American ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Traumatic Injuries ◽  
Severe Deficiency ◽  
Severity Of Injury ◽  
25 Oh Vitamin D ◽  
African American Race

Abstract Background Vitamin D depletion has been associated with increased rate of infections, lengthened hospital stay, and worsened mortality for critically ill patients. The purpose of this study was to evaluate the prevalence and variables associated with vitamin D deficiency in critically ill patients with severe traumatic injuries. Methods Critically ill adult patients admitted to the trauma intensive care unit (ICU) between June 2013 and June 2014, referred to the nutrition support service for enteral or parenteral nutrition, and had a serum 25-hydroxyvitamin D (25-OH vitamin D) concentration determination were retrospectively evaluated. Patients were stratified as vitamin D sufficient, insufficient, deficient, or severely deficient based on a 25-OH vitamin D concentration of 30–80, 20–29.9, 13.1–19.9, and ≤13 ng/mL, respectively. Results One hundred and twenty-one patients out of 158 (76 %) patients were vitamin D deficient or severely deficient. Thirty-one patients (20 %) were insufficient and 6 (4 %) had a normal 25-OH vitamin D concentration. 25-OH vitamin D was determined 7.5 ± 5.1 days after ICU admission. African-Americans had a greater proportion of patients with deficiency or severe deficiency compared to other races (91 versus 64 %, P = 0.02). Penetrating gunshot or knife stab injury, African-American race, and obesity (elevated body mass index) were significantly associated with vitamin D deficiency or severe deficiency: OR 9.23 (1.13, 75.40), 4.0 (1.4, 11.58), and 1.12 (1.03, 1.23), P < 0.05, respectively. Conclusions The majority of critically ill patients with traumatic injuries exhibit vitamin D deficiency or severe deficiency. Penetrating injuries, African-American race, and obesity are significant risk factors for deficiency. Severity of injury, extent of inflammation (elevated C-reactive protein concentration), or hospital admission during the winter season did not significantly influence the prevalence of vitamin D deficiency.

Prevalence and Risk Factors of Vitamin D Deficiency in Critically Ill Patients

2013 ◽  
Vol 12 (4) ◽  
pp. 223-229 ◽  
Author(s):  
Bertrand Sauneuf ◽  
Jennifer Brunet ◽  
Olivier Lucidarme ◽  
Damien Cheyron
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients

Burden and Outcome of Vitamin D Deficiency Among Critically Ill Patients: A Prospective Study

2016 ◽  
Vol 32 (3) ◽  
pp. 378-384 ◽  
Author(s):  
Enas Anwar ◽  
Gehan Hamdy ◽  
Eman Taher ◽  
Esmat Fawzy ◽  
Sherif Abdulattif ◽  
...  
Keyword(s):  
Vitamin D ◽  
Prospective Study ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
A Prospective Study

Is vitamin D deficiency associated with development of Acinetobacter baumannii infections in critically ill patients?

2013 ◽  
Vol 28 (5) ◽  
pp. 735-740 ◽  
Author(s):  
Melda Türkoğlu ◽  
Gülbin Aygencel ◽  
Murat Dizbay ◽  
Ayşe Fitnat Tuncel ◽  
Burcu Arslan Candır ◽  
...  
Keyword(s):  
Vitamin D ◽  
Acinetobacter Baumannii ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients
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