Age-dependent decrease in desflurane concentration for maintaining bispectral index below 50

2015 ◽  
Vol 60 (2) ◽  
pp. 177-182 ◽  
Author(s):  
S. Kanazawa ◽  
Y. Oda ◽  
C. Maeda ◽  
R. Okutani
Keyword(s):  
Bispectral Index ◽  
Age Dependent ◽  
Desflurane Concentration

Fentanyl-mediated reduction in the bispectral index and 95% spectral edge frequency is age-dependent

2003 ◽  
Vol 20 (2) ◽  
pp. 167-169
Author(s):  
N. Anzawa ◽  
K. Hirota ◽  
M. Kitayama ◽  
T. Kushikata ◽  
A. Matsuki
Keyword(s):  
Bispectral Index ◽  
Spectral Edge Frequency ◽  
Spectral Edge ◽  
Age Dependent ◽  
Mediated Reduction

scholarly journals Age-dependent relationship between bispectral index and sedation level

2008 ◽  
Vol 20 (7) ◽  
pp. 492-495 ◽  
Author(s):  
Kazunori Yamashita ◽  
Yoshiaki Terao ◽  
Chiaki Inadomi ◽  
Masafumi Takada ◽  
Makoto Fukusaki ◽  
...  
Keyword(s):  
Bispectral Index ◽  
Sedation Level ◽  
Dependent Relationship ◽  
Age Dependent

Surgical Stimulation Shifts EEG Concentration–Response Relationship of Desflurane

2001 ◽  
Vol 94 (3) ◽  
pp. 390-399 ◽  
Author(s):  
Heiko Röpcke ◽  
Benno Rehberg ◽  
Michael Koenen-Bergmann ◽  
Thomas Bouillon ◽  
Jörgen Bruhn ◽  
...  
Keyword(s):  
Bispectral Index ◽  
Volatile Anesthetic ◽  
Pharmacodynamic Modeling ◽  
Control Group ◽  
Spectral Edge Frequency ◽  
Spectral Edge ◽  
Desflurane Concentration ◽  
Power Frequency ◽  
Median Power Frequency ◽  
Surgical Stimulation

Background Anesthesiologists routinely increase the delivered anesthetic concentration before surgical stimulation in anticipation of increased anesthetic requirement to achieve certain goals (e.g., amnesia, unconsciousness, and immobility). Electroencephalographic monitoring is one method of determining indirectly anesthetic effect on the brain. The present study investigated the effect of surgical stimuli on the concentration-response relation of desflurane-induced electroencephalographic changes. Methods The electroencephalographic activity was recorded from 24 female patients who received only desflurane after a single induction dose of propofol. Twelve patients served as a control group before surgical stimulation. The other 12 patients, all undergoing lower abdominal surgery, were investigated between opening and closure of the peritoneum. Desflurane vaporizer settings were randomly increased and decreased between 0.5 and 1.6 minimum alveolar concentration as long as anesthesia was considered adequate. Spectral edge frequency 95, median power frequency, and Bispectral Index were calculated. Desflurane effect-site concentrations and the concentration-effect curves for spectral edge frequency 95, median power frequency, and Bispectral Index were determined by simultaneous pharmacokinetic and pharmacodynamic modeling. Results Surgical stimulation shifted the desflurane concentration-electroencephalographic effect curves for spectral edge frequency 95, median power frequency, and Bispectral Index toward higher desflurane concentrations. In the unstimulated group, 2.2 +/- 0.74 vol% desflurane were necessary to achieve a Bispectral Index of 50, whereas during surgery, 6.8 +/- 0.98 vol% (mean +/- SE) were required. Conclusions During surgery, higher concentrations of the volatile anesthetic are required to achieve a desired level of cortical electrical activity and, presumably, anesthesia.

scholarly journals Comparison of bispectral index-guided and fixed-gas concentration techniques in desflurane and remifentanil anesthesia: A randomized controlled trial

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241828
Author(s):  
Seong Mi Yang ◽  
Yoo Sun Jung ◽  
Chul-Woo Jung ◽  
Won Ho Kim ◽  
Soo Bin Yoon ◽  
...  
Keyword(s):  
Bispectral Index ◽  
Minimum Alveolar Concentration ◽  
Controlled Trial ◽  
Systolic Arterial Pressure ◽  
Hemodynamic Instability ◽  
Gas Concentration ◽  
Randomized Controlled ◽  
Balanced Anesthesia ◽  
Desflurane Concentration ◽  
Secondary Endpoints

Anesthesia with desflurane and remifentanil can be maintained with either fixed or titrated desflurane concentration. We hypothesized that the fixed-gas concentration (FG) method would reduce the number of anesthetic titrations without hypnotic and hemodynamic instability compared to the bispectral index (BIS)-guided (BG) method. Forty-eight patients were randomly allocated to the FG or BG groups. In the FG group, desflurane vaporizer setting was fixed at 1 age-corrected minimum alveolar concentration (MAC). In the BG group, desflurane was titrated to target a BIS level at 50. Remifentanil was titrated to maintain a systolic arterial pressure (SAP) of 120 mmHg in both groups. Our primary endpoint was the hypnotic stability measured by the wobble of BIS in performance analysis, and the secondary endpoints included the wobble of SAP, mean BIS value during surgery, and the number of anesthetic titrations. The BIS in the FG group showed significantly less wobble (3.9 ± 1.1% vs 5.5 ± 1.5%, P <0.001) but lower value (33 ± 6 vs 46 ± 7, P <0.001) than BG group. The wobble of SAP showed no difference between groups [median (inter-quartile range), 5.0 (4.1–7.5)% vs 5.2 (4.2–8.3)%, P = 0.557]. The numbers of anesthetic titrations in the FG group were significantly lower than the BG group (0 ± 0 vs 8 ± 5, P<0.001 for desflurane, 13 ± 13 vs 22 ± 17, P = 0.047 for remifentanil). Less wobble in BIS and reduced anesthetic titration without hemodynamic instability during the FG technique may be practical in balanced anesthesia using desflurane and remifentanil anesthesia. Clinical trial: This study was registered at ClinicalTrials.gov (NCT02283866).

The effects of bispectral index monitoring on end-tidal desflurane concentration

2004 ◽  
Vol 21 (Supplement 32) ◽  
pp. 40
Author(s):  
C. Kaymak ◽  
S. A. Takmaz ◽  
M. Ozen ◽  
A. O. Ozcan ◽  
Y. Gulhan ◽  
...  
Keyword(s):  
Bispectral Index ◽  
Bispectral Index Monitoring ◽  
Desflurane Concentration ◽  
End Tidal

Fentanyl-mediated reduction in the bispectral index and 95% spectral edge frequency is age-dependent

2005 ◽  
Vol 20 (2) ◽  
pp. 167-169
Author(s):  
N. Anzawa ◽  
K. Hirota ◽  
M. Kitayama ◽  
T. Kushikata ◽  
A. Matsuki
Keyword(s):  
Bispectral Index ◽  
Spectral Edge Frequency ◽  
Spectral Edge ◽  
Age Dependent ◽  
Mediated Reduction

Effects of Hyperoxia on Lung Utrastructure

1970 ◽  
Vol 28 ◽  
pp. 26-27
Author(s):  
Gladys Harrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Light Microscopy ◽  
Oxygen Effects ◽  
Age Dependent ◽  
The Central Nervous System ◽  
The Subject ◽  
Space Age ◽  
Alveolar Septa ◽  
Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

1248: Impact of Surgical Treatment of Renal Carcinoma on Renal Function and Blood Pressure: A Race- and Age-Dependent Association

2007 ◽  
Vol 177 (4S) ◽  
pp. 411-412
Author(s):  
Javier Miller ◽  
Angela Smith ◽  
Kris Gunn ◽  
Erik Kouba ◽  
Eric M. Wallen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Surgical Treatment ◽  
Renal Carcinoma ◽  
Age Dependent
Sign in / Sign up

Export Citation Format

Share Document