The LMA-SupremeTMas an intubation conduit in patients with known difficult airways: a prospective evaluation study

2012 ◽  
Vol 57 (1) ◽  
pp. 77-81 ◽  
Author(s):  
T. C. R. V. VAN ZUNDERT ◽  
D. T. WONG ◽  
A. A. J. VAN ZUNDERT
Keyword(s):  
Evaluation Study ◽  
Prospective Evaluation ◽  
Difficult Airways

Multicenter prospective evaluation study of endoscopic ultrasound‐guided hepaticogastrostomy combined with antegrade stenting (with video)

2017 ◽  
Vol 30 (2) ◽  
pp. 252-259 ◽  
Author(s):  
Takeshi Ogura ◽  
Masayuki Kitano ◽  
Mamoru Takenaka ◽  
Atsushi Okuda ◽  
Kosuke Minaga ◽  
...  
Keyword(s):  
Endoscopic Ultrasound ◽  
Evaluation Study ◽  
Prospective Evaluation ◽  
Ultrasound Guided

Influence of transvaginal ultrasound examination on quantitative vaginal fibronectin measurements: a prospective evaluation study

2017 ◽  
Vol 45 (1) ◽  
Author(s):  
Michaela Golic ◽  
Jan-Peter Siedentopf ◽  
Franziska Pauly ◽  
Larry Hinkson ◽  
Wolfgang Henrich ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Transvaginal Ultrasound ◽  
Evaluation Study ◽  
Cervical Length ◽  
Prospective Evaluation ◽  
Fetal Fibronectin ◽  
A Value ◽  
Measurement Results ◽  
Perinatal Center ◽  
Random Fluctuations

AbstractObjective:The most important parameter in prediction of preterm birth is the cervical length measured by transvaginal ultrasound. In cases with mid-range cervical length (10–30 mm), prediction of preterm birth is difficult. In these cases, testing for cervicovaginal fluid fetal fibronectin (fFN) can improve prediction. However, it is unclear whether transvaginal ultrasound itself influences the fFN result. The purpose of this study was to evaluate this issue independent of gestational age and cervical length.Methods:A prospective evaluation study with 96 cases of pregnant women at 20–41 weeks of gestation was conducted in a tertiary perinatal center. A comparison of cervicovaginal fFN samples before and immediately after transvaginal ultrasound was performed. Fetal fibronectin was measured using the Hologic Rapid fFN 10Q system. It was analyzed quantitatively and qualitatively with ≥50 ng/mL as threshold for “positive”. Changes in fFN values following transvaginal ultrasound were measured.Results:Ninety-six percent (69/72) of women with a fFN concentration of <26 ng/mL before ultrasound had a corresponding fFN value <26 ng/mL after ultrasound. Ninety-three percent (13/14) of women with a fFN concentration of ≥100 ng/mL before ultrasound had a corresponding fFN value ≥100 ng/mL after ultrasound. In 80% (4/5) of women with a positive fFN sample but with a value <100 ng/mL, it turned negative (<50 ng/mL) after ultrasound. For fFN concentrations ≥100 ng/mL, there are high random fluctuations in the measurement results.Conclusions:Fetal fibronectin values of <26 ng/mL (for “negative”) and ≥100 ng/mL (for “positive”) from samples taken after ultrasound provide the same qualitative information as when sampled before ultrasound. For the correct interpretation however, quantitative analysis is necessary.

scholarly journals Checklist for psychosocial risk evaluation: a prospective evaluation study

2016 ◽  
Vol 67 (1) ◽  
pp. 7-12 ◽  
Author(s):  
M. Weigl ◽  
A. Müller ◽  
A. Paramythelli ◽  
P. Angerer ◽  
R. Petru
Keyword(s):  
Risk Evaluation ◽  
Evaluation Study ◽  
Psychosocial Risk ◽  
Prospective Evaluation

scholarly journals Regulatory Forum*

2016 ◽  
Vol 44 (8) ◽  
pp. 1069-1071 ◽  
Author(s):  
W. Michael Peden
Keyword(s):  
Chronic Toxicity ◽  
Regulatory Policy ◽  
Evaluation Study ◽  
Weight Of Evidence ◽  
Prospective Evaluation ◽  
International Council ◽  
Carcinogenicity Study ◽  
Toxicity Studies ◽  
Extensive Evaluation ◽  
Expert Working Group

Revision of the International Council for Harmonization (ICH) S1 guidance for rat carcinogenicity studies to be more selective of compounds requiring a 2-year rat carcinogenicity study has been proposed following extensive evaluation of rat carcinogenicity and chronic toxicity studies by industry and drug regulatory authorities. To inform the ICH S1 expert working group in their potential revision of ICH S1, a prospective evaluation study was initiated in 2013, in which sponsors would assess the pharmacologic and toxicologic findings present in the chronic toxicity studies and predict a positive or negative carcinogenicity outcome using a weight of evidence argument (a carcinogenicity assessment document [CAD]). The Scientific and Regulatory Policy Committee was asked by the Society of Toxicology Pathology (STP) executive committee to track these changes with ICH S1 and inform the STP membership of status changes. This commentary is intended to provide a brief summary of recent changes to the CAD guidance and highlight the importance of STP membership participation in the process of CAD submissions.

Cochlear Implant Therapy Improves the Quality of Life in Older Patients—A Prospective Evaluation Study

2020 ◽  
Vol 41 (9) ◽  
pp. 1214-1221
Author(s):  
Christian Issing ◽  
Uwe Baumann ◽  
Johannes Pantel ◽  
Timo Stöver
Keyword(s):  
Quality Of Life ◽  
Cochlear Implant ◽  
Older Patients ◽  
Evaluation Study ◽  
Prospective Evaluation ◽  
Implant Therapy
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