Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota

2020 ◽  
Vol 85 (6) ◽  
pp. 1872-1890
Author(s):  
Dongdong Wang ◽  
Xiangxiang Zhu ◽  
Xiaocui Tang ◽  
Hongye Li ◽  
Xie Yizhen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Antitumor Effects ◽  
Hericium Erinaceus

scholarly journals Antitumor, Anti-inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1339 ◽  
Author(s):  
Geir Hetland ◽  
Jon-Magnus Tangen ◽  
Faiza Mahmood ◽  
Mohammad Reza Mirlashari ◽  
Lise Sofie Haug Nissen-Meyer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gut Microbiota ◽  
Clinical Findings ◽  
Grifola Frondosa ◽  
Special Focus ◽  
Agaricus Blazei ◽  
Antitumor Effects ◽  
Medicinal Mushrooms ◽  
Hericium Erinaceus ◽  
Anti Inflammatory

Since the 1980s, medicinal effects have been documented in scientific studies with the related Basidiomycota mushrooms Agaricus blazei Murill (AbM), Hericium erinaceus (HE) and Grifola frondosa (GF) from Brazilian and Eastern traditional medicine. Special focus has been on their antitumor effects, but the mushrooms’ anti-inflammatory and antiallergic properties have also been investigated. The antitumor mechanisms were either direct tumor attack, e.g., apoptosis and metastatic suppression, or indirect defense, e.g., inhibited tumor neovascularization and T helper cell (Th) 1 immune response. The anti-inflammatory mechanisms were a reduction in proinflammatory cytokines, oxidative stress and changed gut microbiota, and the antiallergic mechanism was amelioration of a skewed Th1/Th2 balance. Since a predominant Th2 milieu is also found in cancer, which quite often is caused by a local chronic inflammation, the three conditions—tumor, inflammation and allergy—seem to be linked. Further mechanisms for HE were increased nerve and beneficial gut microbiota growth, and oxidative stress regulation. The medicinal mushrooms AbM, HE and GF appear to be safe, and can, in fact, increase longevity in animal models, possibly due to reduced tumorigenesis and oxidation. This article reviews preclinical and clinical findings with these mushrooms and the mechanisms behind them.

scholarly journals Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Shichang Bian ◽  
Hongjuan Wan ◽  
Xinyan Liao ◽  
Weisheng Wang
Keyword(s):  
Colon Cancer ◽  
Treatment Group ◽  
16S Rrna ◽  
Gut Microbiota ◽  
High Throughput Sequencing ◽  
Potential Mechanism ◽  
Inhibitory Effects ◽  
Antitumor Effects

The flavonoid apigenin is common to many plants. Although the responsible mechanisms have yet to be elucidated, apigenin demonstrates tumor suppression in vitro and in vivo. This study uses an azoxymethane (AOM)/dextran sodium sulfate- (DSS-) induced colon cancer mouse model to investigate apigenin’s potential mechanism of action exerted through its effects upon gut microbiota. The size and quantity of tumors were reduced significantly in the apigenin treatment group. Using 16S rRNA high-throughput sequencing of fecal samples, the composition of gut microbiota was significantly affected by apigenin. Further experiments in which gut microbiota were reduced and feces were transplanted provided further evidence of apigenin-modulated gut microbiota exerting antitumor effects. Apigenin was unable to reduce the number or size of tumors when gut microbiota were depleted. Moreover, tumor inhibition effects were initiated following the transplant of feces from mice treated with apigenin. Our findings suggest that the effect of apigenin on the composition of gut microbiota can suppress tumors.

scholarly journals Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota

2017 ◽  
Vol 8 ◽  
Author(s):  
Chen Diling ◽  
Zheng Chaoqun ◽  
Yang Jian ◽  
Li Jian ◽  
Su Jiyan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fungal Protein ◽  
Hericium Erinaceus

scholarly journals Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota

Oncotarget ◽  
2017 ◽  
Vol 8 (49) ◽  
pp. 85838-85857 ◽  
Author(s):  
Chen Diling ◽  
Yang Xin ◽  
Zheng Chaoqun ◽  
Yang Jian ◽  
Tang Xiaocui ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gut Microbiota ◽  
Bowel Disease ◽  
Hericium Erinaceus ◽  
Inflammatory Bowel

scholarly journals Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 1008
Author(s):  
Xiao-Qian Xie ◽  
Yan Geng ◽  
Qijie Guan ◽  
Yilin Ren ◽  
Lin Guo ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Biochemical Markers ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Alpha Diversity ◽  
Streptococcus Thermophilus ◽  
Protective Effects ◽  
Hericium Erinaceus ◽  
Blood Indices ◽  
Serum Biochemical

Hericium erinaceus (H. erinaceus) is widely studied as a medicinal and edible fungus. Recent studies have shown that H. erinaceus has protective effects for diseases, such as inflammatory bowel disease and cancer, which are related to gut microbiota. To investigate the benefits of H. erinaceus intake on gut microbiota and blood indices in adulthood, we recruited 13 healthy adults to consume H. erinaceus powder as a dietary supplement. Blood changes due to H. erinaceus consumption were determined by routine hematological examination and characterized by serum biochemical markers. Microbiota composition was profiled by 16S ribosomal RNA gene sequencing. Results showed that daily H. erinaceus supplementation increased the alpha diversity within the gut microbiota community, upregulated the relative abundance of some short-chain fatty acid (SCFA) producing bacteria (Kineothrix alysoides, Gemmiger formicilis, Fusicatenibacter saccharivorans, Eubacterium rectale, Faecalibacterium prausnitzii), and downregulated some pathobionts (Streptococcus thermophilus, Bacteroides caccae, Romboutsia timonensis). Changes within the gut microbiota were correlated with blood chemical indices including alkaline phosphatase (ALP), low-density lipoprotein (LDL), uric acid (UA), and creatinine (CREA). Thus, we found that the gut microbiota alterations may be part of physiological adaptations to a seven-day H. erinaceus supplementation, potentially influencing beneficial health effects.

Value added immunoregulatory polysaccharides of Hericium erinaceus and their effect on the gut microbiota

2021 ◽  
pp. 117668
Author(s):  
Yang Yang ◽  
Haiqing Ye ◽  
Changhui Zhao ◽  
Li Ren ◽  
Cuina Wang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Value Added ◽  
Hericium Erinaceus

scholarly journals Suppression of local type I interferon by gut microbiota–derived butyrate impairs antitumor effects of ionizing radiation

2021 ◽  
Vol 218 (3) ◽  
Author(s):  
Kaiting Yang ◽  
Yuzhu Hou ◽  
Yuan Zhang ◽  
Hua Liang ◽  
Anukriti Sharma ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Gut Microbiota ◽  
Therapeutic Option ◽  
Radiation Sensitivity ◽  
Cytotoxic T Cell ◽  
Tumor Control ◽  
Type I ◽  
Antitumor Effects ◽  
Selective Targeting ◽  
T Cell Immune Responses

The antitumor effects of ionizing radiation (IR) are mediated in part through activation of innate and adaptive immunity. Here we report that gut microbiota influences tumor control following IR. Vancomycin decreased the abundance of butyrate-producing gut bacteria and enhanced antitumor responses to IR. Oral administration of Lachnospiraceae, a family of vancomycin-sensitive bacteria, was associated with increased systemic and intratumoral butyric acid levels and impaired the efficacy of IR in germ-free (GF) mice. Local butyrate inhibited STING-activated type I IFN expression in dendritic cells (DCs) through blockade of TBK1 and IRF3 phosphorylation, which abrogated IR-induced tumor-specific cytotoxic T cell immune responses without directly protecting tumor cells from radiation. Our findings demonstrate that the selective targeting of butyrate-producing microbiota may provide a novel therapeutic option to enhance tumor radiation sensitivity.

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