Baseline carotid intima media thickness is associated with cardiovascular morbidity and mortality in peritoneal dialysis patients

Author(s):  
Ebru Asicioglu ◽  
Arzu Velioglu ◽  
Hakki Arikan ◽  
Mehmet Koc ◽  
Serhan Tuglular ◽  
...  
2003 ◽  
Vol 131 (9-10) ◽  
pp. 382-388 ◽  
Author(s):  
Tatjana Damjanovic ◽  
Nada Dimkovic

Atherosclerosis is significant risk factor for cardiovascular morbidity and mortality in dialysis patients. Aim of the study was ultrasound evaluation of intima media thickness on carotid arteries (as a marker of atherosclerosis), in dialysis patients and its correlation with proposed risk factors. Intima media thickness was measured in 45 dialysis patients with no signs of cardiovascular diseases (15 on peritoneal dialysis, group I,30 on hemodialysis, group II) and 20 healthy controls. The mean carotid artery intima media thickness was significantly higher in dialysis patients than in control group. According to intima media thickness, dialysis patients were divided in group A (patient with intima media thickness less or equal 0,720 mm) and group B (intima media thickness higher then 0,720mm). Intima media thickness in bout group was correlated with proposed risk factors. In group A there was not significant correlation of intima media thickness with risk factors. In group B significant correlation have been found between intima media thickness and LDL, VLDL cholesterol, body mass index and systolic, diastolic and mean blood pressure. Although atherosclerosis was not the only cause for cardiovascular morbidity and mortality, it has a dominant role in dialysis patients. Augmented intima media thickness could be early marker of atherosclerosis. The risk factors of great influence on intima media thickness are lipid disturbances, obesity and hypertension.


2006 ◽  
Vol 21 (9) ◽  
pp. 2513-2520 ◽  
Author(s):  
Marlies Noordzij ◽  
Johanna C. Korevaar ◽  
Willem J. Bos ◽  
Elisabeth W. Boeschoten ◽  
Friedo W. Dekker ◽  
...  

2013 ◽  
Vol 45 (5) ◽  
pp. 1437-1443 ◽  
Author(s):  
Ebru Asicioglu ◽  
Arzu Kahveci ◽  
Hakkı Arikan ◽  
Mehmet Koc ◽  
Serhan Tuglular ◽  
...  

Renal Failure ◽  
2015 ◽  
Vol 37 (3) ◽  
pp. 433-438
Author(s):  
Mehmet Büyükbakkal ◽  
Başol Canbakan ◽  
Bariş Eser ◽  
Özlem Yayar ◽  
Zafer Ercan ◽  
...  

2008 ◽  
Vol 28 (4) ◽  
pp. 397-402 ◽  
Author(s):  
Li-Tao Cheng ◽  
Yan-Li Gao ◽  
Chao Qin ◽  
Jun-Ping Tian ◽  
Yue Gu ◽  
...  

Objective In dialysis patients, volume overhydration is common and is related to increased risk of cardiovascular morbidity and mortality. However, it remains unclear whether volume overload imposes those detrimental effects through endothelial dysfunction. Methods In this cross-sectional study, 81 stable patients on continuous ambulatory peritoneal dialysis in a single center were recruited. Volume status was evaluated by extracellular water, assessed by bioimpedance analysis, and normalized to individual height (nECW). Endothelial function was estimated by endothelial-dependent flow-mediated dilatation (FMD) of the brachial artery and expressed as percentage change relative to baseline diameter. Results There were 37 male and 44 female patients (mean age 61 ± 12 years, dialysis vintage 20 ± 23 months). FMD in female patients was significantly higher than that in male patients (9.17% ± 6.23% vs 6.31% ± 5.01%, p < 0.05). FMD was negatively correlated with weight ( r = -0.308, p < 0.01), body mass index ( r = -0.242, p < 0.05), systolic blood pressure ( r = -0.228, p < 0.05), ECW ( r = -0.404, p < 0.001), and nECW ( r = -0.418, p < 0.001). No correlation was found between FMD and other variables. In multiple stepwise regression analysis, calcium x phosphate product (² = 0.422, p < 0.001), nECW (² = -0.343, p < 0.01), and dialysis vintage (² = -0.237, p < 0.05) were independent determinants of FMD (adjusted R2 = 0.327 for this model). Conclusion There was independent correlation between index of volume status and FMD, and higher nECW was related to worse endothelial function. The results of this study may help us understand the underlying mechanism of volume overhydration leading to increased cardiovascular morbidity and mortality in dialysis patients.


2007 ◽  
Vol 8 (1) ◽  
pp. 219
Author(s):  
H. Kocak ◽  
F. Ersoy ◽  
E. Mahsereci ◽  
C. Ermiletters ◽  
K. Ceken ◽  
...  

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