scholarly journals Factors contributing to decreased protein stability when aspartic acid residues are in β-sheet regions

2009 ◽  
Vol 11 (7) ◽  
pp. 1687-1694 ◽  
Author(s):  
P.R. Pokkuluri ◽  
M. Gu ◽  
X. Cai ◽  
R. Raffen ◽  
F.J. Stevens ◽  
...  
Keyword(s):  
Protein Stability ◽  
Aspartic Acid ◽  
Β Sheet

scholarly journals The effects of thioamide backbone substitution on protein stability: a study in α-helical, β-sheet, and polyproline II helical contexts

2017 ◽  
Vol 8 (4) ◽  
pp. 2868-2877 ◽  
Author(s):  
Christopher R. Walters ◽  
D. Miklos Szantai-Kis ◽  
Yitao Zhang ◽  
Zachary E. Reinert ◽  
W. Seth Horne ◽  
...  
Keyword(s):  
Protein Structure ◽  
Protein Stability ◽  
Peptide Bond ◽  
Single Atom ◽  
Polyproline Ii ◽  
Β Sheet

Thioamides are single atom substitutions of the peptide bond that serve as versatile probes of protein structure.

scholarly journals Boosting protein stability with the computational design of β-sheet surfaces

2016 ◽  
Vol 25 (3) ◽  
pp. 702-710 ◽  
Author(s):  
Doo Nam Kim ◽  
Timothy M. Jacobs ◽  
Brian Kuhlman
Keyword(s):  
Protein Stability ◽  
Computational Design ◽  
Β Sheet

scholarly journals Crystal structure of N-{N-[N-(tert-butoxycarbonyl)-L-α-aspartyl]-L-α-aspartyl}-L-α-aspartic acid 14,24,34-trimethyl ester 31-2-oxo-2-phenylethyl ester {Boc-[Asp(OMe)]3-OPac}

2019 ◽  
Vol 75 (5) ◽  
pp. 585-588
Author(s):  
Takuma Kato ◽  
Saki Kishimoto ◽  
Akiko Asano ◽  
Mitsunobu Doi
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonds ◽  
Aspartic Acid ◽  
Protecting Group ◽  
Peptide Bonds ◽  
Axis Direction ◽  
Sheet Structure ◽  
Β Sheet

In the title homotripeptide {Boc-[Asp(OMe)]3-OPac}, C28H37N3O13, all peptide bonds adopt an s-trans conformation with respect to the N—H and C=O groups. In the crystal, N—H...O hydrogen bonds result in an infinite parallel β-sheet structure running along the b-axis direction. The Boc protecting group at the N-terminus of the peptide is disordered over two sites with occupancy factors of 0.504 (5) and 0.496 (5).

scholarly journals Structural evidence for solvent-stabilisation by aspartic acid as a mechanism for halophilic protein stability in high salt concentrations

2016 ◽  
Vol 18 (27) ◽  
pp. 18054-18062 ◽  
Author(s):  
Samuel Lenton ◽  
Danielle L. Walsh ◽  
Natasha H. Rhys ◽  
Alan K. Soper ◽  
Lorna Dougan
Keyword(s):  
Protein Stability ◽  
Aspartic Acid ◽  
High Salt

Halophilic organisms have adapted to survive in high salt environments, where mesophilic organisms would perish.

Analysis of Aspartic Acid at Position 9 of the HLA-C Molecule in Patients with Psoriasis Vulgaris.

1996 ◽  
Vol 58 (6) ◽  
pp. 991-993
Author(s):  
Eishin MORITA ◽  
Susumu SHINODA ◽  
Eiichi GYOTOKU ◽  
Satoko HIHARA ◽  
Shoso YAMAMOTO
Keyword(s):  
Aspartic Acid ◽  
Psoriasis Vulgaris
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