scholarly journals High and low oxygen affinity conformations of T state hemoglobin

2008 ◽  
Vol 10 (11) ◽  
pp. 2401-2407 ◽  
Author(s):  
Stefano Bruno ◽  
Maria Bonaccio ◽  
Stefano Bettati ◽  
Claudio Rivetti ◽  
Cristiano Viappiani ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
Low Oxygen ◽  
T State ◽  
Low Oxygen Affinity

Structures of R- and T-state hemoglobin Bassett: elucidating the structural basis for the low oxygen affinity of a mutant hemoglobin

2005 ◽  
Vol 61 (2) ◽  
pp. 156-162 ◽  
Author(s):  
Martin K. Safo ◽  
Osheiza Abdulmalik ◽  
Hsiang-Ru Lin ◽  
Toshio Asakura ◽  
Donald J. Abraham
Keyword(s):  
Oxygen Affinity ◽  
Structural Basis ◽  
Low Oxygen ◽  
T State ◽  
Low Oxygen Affinity

scholarly journals Structure of liganded T-state haemoglobin from cat (Felis silvestris catus), a low oxygen-affinity species, in two different crystal forms

2014 ◽  
Vol 70 (7) ◽  
pp. 1898-1906 ◽  
Author(s):  
Moovarkumudalvan Balasubramanian ◽  
Ponnuraj Sathya Moorthy ◽  
Kamariah Neelagandan ◽  
Ramya Ramadoss ◽  
Prasanna R. Kolatkar ◽  
...  
Keyword(s):  
Mammalian Species ◽  
Oxygen Affinity ◽  
Structural Features ◽  
Low Oxygen ◽  
Felis Silvestris Catus ◽  
Binding Properties ◽  
Crystal Forms ◽  
Allosteric Effectors ◽  
T State ◽  
Low Oxygen Affinity

Haemoglobin (Hb) is an iron-containing metalloprotein which plays a major role in the transportation of oxygen from the lungs to tissues and of carbon dioxide back to the lungs. Hb is in equilibrium between low-affinity tense (T) and high-affinity relaxed (R) states associated with its unliganded and liganded forms, respectively. Mammalian species can be classified into two groups on the basis of whether they express `high' or `low' oxygen-affinity Hbs. Although Hbs from the former group have been studied extensively, a more limited number of structural studies have been performed for low oxygen-affinity Hbs. Here, the crystal structure of low oxygen-affinity cat methaemoglobin (metHb) has been solved at 2.0 and 2.4 Å resolution in two different crystal forms. Even though both structures are fully liganded, they unusually adopt a T-state-like quaternary conformation but with several localized R-like tertiary-structural and quaternary-structural features. The study provides atomic-level insights into the ligand-binding properties of this Hb, including its low cooperativity, blunt response to allosteric effectors and low affinity for oxygen, as well as further contributing to the mechanism underlying Hb allostery.

HB Washtenaw [βT11(A8)VAL-PHE]: An Electrophoretically Silent, Unstable, Low Oxygen Affinity Variant Associated with Anemia and Chronic Cyanosis

Hemoglobin ◽  
1994 ◽  
Vol 18 (4-5) ◽  
pp. 285-295 ◽  
Author(s):  
K. Krishnan ◽  
F. Martinez ◽  
R. T. Wille ◽  
R. T. Jones ◽  
D. T. Shin ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
Low Oxygen ◽  
Low Oxygen Affinity

Purification, Crystallization and Preliminary X-Ray Diffraction Studies on Goat (Capra hircus) Hemoglobin - A Low Oxygen Affinity Species

2009 ◽  
Vol 16 (4) ◽  
pp. 454-456 ◽  
Author(s):  
Ponnuraj Moorthy ◽  
Kamariah Neelagandan ◽  
Moovarkumudalvan Balasubramanian ◽  
Mondikalipudur Ponnuswamy
Keyword(s):  
Oxygen Affinity ◽  
Capra Hircus ◽  
Low Oxygen ◽  
X Ray Diffraction ◽  
X Ray ◽  
Hemoglobin A ◽  
Low Oxygen Affinity

scholarly journals Hemoglobin Titusville: a rare low oxygen affinity hemoglobinopathy

2017 ◽  
Vol 5 (6) ◽  
pp. 1011-1012 ◽  
Author(s):  
Senan John Yasar ◽  
Vivian Irene Ravn Berg ◽  
Asim Ahmad ◽  
Donald Doll
Keyword(s):  
Oxygen Affinity ◽  
Low Oxygen ◽  
Low Oxygen Affinity

scholarly journals Haemoglobin caribbean β91 (F7) Leu → Arg: A mildly unstable haemoglobin with a low oxygen affinity

FEBS Letters ◽  
1976 ◽  
Vol 69 (1-2) ◽  
pp. 99-102 ◽  
Author(s):  
E. Ahern ◽  
A.V. Ahern ◽  
A.T. Hilton ◽  
G.R. Sergeant ◽  
B.E. Sergeant ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
Low Oxygen ◽  
Low Oxygen Affinity

Hemoglobin Titusville, a low oxygen affinity variant hemoglobin, in a family of Northern European background

2004 ◽  
Vol 77 (4) ◽  
pp. 384-386 ◽  
Author(s):  
Hong-yuan Luo ◽  
Ian Irving ◽  
John Prior ◽  
Erna Lim ◽  
Shawn H. Eung ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
Low Oxygen ◽  
Variant Hemoglobin ◽  
Northern European ◽  
Low Oxygen Affinity
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