scholarly journals The crystal structure of human receptor protein tyrosine phosphatase κ phosphatase domain 1

2006 ◽  
Vol 15 (6) ◽  
pp. 1500-1505 ◽  
Author(s):  
Jeyanthy Eswaran ◽  
Judit É. Debreczeni ◽  
Emma Longman ◽  
Alastair J. Barr ◽  
Stefan Knapp
Keyword(s):  
Crystal Structure ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Protein ◽  
Phosphatase Domain ◽  
Protein Tyrosine ◽  
Receptor Protein Tyrosine Phosphatase ◽  
Human Receptor

scholarly journals Catalytic and substrate promiscuity: distinct multiple chemistries catalysed by the phosphatase domain of receptor protein tyrosine phosphatase

2016 ◽  
Vol 473 (14) ◽  
pp. 2165-2177 ◽  
Author(s):  
Bharath Srinivasan ◽  
Hanna Marks ◽  
Sreyoshi Mitra ◽  
David M. Smalley ◽  
Jeffrey Skolnick
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Enzymatic Activities ◽  
Enzyme Evolution ◽  
Protein Domain ◽  
Receptor Protein ◽  
Phosphatase Domain ◽  
Protein Tyrosine ◽  
Receptor Protein Tyrosine Phosphatase ◽  
Substrate Promiscuity

This work reports novel sugar hydrolase and diesterase enzymatic activities in the phosphatase domain (PD) of PTPRδ in addition to monoester hydrolysis. Discovery of diverse enzymatic activities in the same protein domain has tremendous implications for understanding enzyme evolution.

scholarly journals The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells

Oncotarget ◽  
2018 ◽  
Vol 9 (34) ◽  
pp. 23334-23348 ◽  
Author(s):  
Sabrina D’Agostino ◽  
Delia Lanzillotta ◽  
Mariaconcetta Varano ◽  
Cirino Botta ◽  
Antonio Baldrini ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Lung Cancer Cells ◽  
Receptor Protein ◽  
Protein Tyrosine ◽  
Receptor Protein Tyrosine Phosphatase
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