scholarly journals NMR characterization of interleukin-2 in complexes with the IL-2Ralpha receptor component, and with low molecular weight compounds that inhibit the IL-2/IL-Ralpha interaction

2003 ◽  
Vol 12 (4) ◽  
pp. 811-822 ◽  
Author(s):  
S. D. Emerson
Keyword(s):  
Molecular Weight ◽  
Interleukin 2 ◽  
Low Molecular Weight ◽  
Receptor Component ◽  
Nmr Characterization ◽  
Low Molecular Weight Compounds

scholarly journals Inhibitors of Pantothenate Kinase: Novel Antibiotics for Staphylococcal Infections

2003 ◽  
Vol 47 (6) ◽  
pp. 2051-2055 ◽  
Author(s):  
Anthony E. Choudhry ◽  
Tracy L. Mandichak ◽  
John P. Broskey ◽  
Richard W. Egolf ◽  
Cynthia Kinsland ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Staphylococcus Aureus ◽  
Biosynthetic Pathway ◽  
Coenzyme A ◽  
Low Molecular Weight ◽  
Pantothenate Kinase ◽  
Staphylococcal Infections ◽  
Low Molecular Weight Compounds ◽  
Novel Antibiotics

ABSTRACT Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.

Synthesis and complete NMR characterization of methacrylateendcapped poly(ortho-esters)

e-Polymers ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Bert Paesen ◽  
Tom Baekelandt ◽  
Jorge Heller ◽  
José C. Martins ◽  
Etienne H. Schacht
Keyword(s):  
Molecular Weight ◽  
Synthesis Method ◽  
Low Molecular Weight ◽  
Analysis Tool ◽  
Ortho Ester ◽  
H Nmr ◽  
Nmr Characterization ◽  
Ortho Esters ◽  
Single Reaction

AbstractIn this paper a synthesis method for low molecular weight poly(orthoesters) with photo crosslinkable methacrylate endgroups is presented. Using this procedure, the molecular weight could be controlled and the desired endgroup functionality was introduced in a single reaction step. The detailed characterization of the molecular structure of bismethacrylate endcapped poly(ortho-esters) using NMR affords a re-evaluation of previous assignments reported for similar poly(ortho-ester) polymers. In addition, the use of diffusion filtered 1D 1H NMR spectroscopy as a simple but effective analysis tool that allows to distinguish resonance contributions from impurities and low molecular weight compounds, most probably the result of degradation, from those of the full size polymer, is demonstrated.

Low Molecular Weight Microfibers with Light Sensing Properties

2017 ◽  
Vol 54 (4) ◽  
pp. 655-658
Author(s):  
Andrei Bejan ◽  
Dragos Peptanariu ◽  
Bogdan Chiricuta ◽  
Elena Bicu ◽  
Dalila Belei
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
X Ray Diffraction ◽  
Aromatic Rings ◽  
X Ray ◽  
Force Microscopy ◽  
Light Sensing ◽  
Sensing Applications ◽  
Atomic Force ◽  
Low Molecular Weight Compounds

Microfibers were obtained from organic low molecular weight compounds based on heteroaromatic and aromatic rings connected by aliphatic spacers. The obtaining of microfibers was proved by scanning electron microscopy. The deciphering of the mechanism of microfiber formation has been elucidated by X-ray diffraction, infrared spectroscopy, and atomic force microscopy measurements. By exciting with light of different wavelength, florescence microscopy revealed a specific optical response, recommending these materials for light sensing applications.

Inhibitors of Cholinesterases in Pharmacology: the Current Trends

2020 ◽  
Vol 20 (15) ◽  
pp. 1532-1542 ◽  
Author(s):  
Miroslav Pohanka
Keyword(s):  
Molecular Weight ◽  
Cholinesterase Inhibitors ◽  
Recent Literature ◽  
Nerve Agents ◽  
Low Molecular Weight ◽  
Toxic Compounds ◽  
Current Trends ◽  
Low Molecular Weight Compounds ◽  
Wide Group ◽  
Anti Inflammation

Inhibitors of cholinesterases are a wide group of low molecular weight compounds with a significant role in the current pharmacology. Besides the pharmacological importance, they are also known as toxic compounds like military nerve agents. In the pharmacology, drugs for Alzheimer disease, myasthenia gravis and prophylaxis of poisoning by nerve agents can be mentioned as the relevant applications. Besides this, anti-inflammation and antiphrastic drugs are other pharmacological applications of these inhibitors. This review is focused on a survey of cholinesterase inhibitors with known or expected pharmacological impact and indications of their use. Recent literature with comments is provided here as well.

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