Free-Form Tactile Sensor Using 3-Dimensional Shape Capture Sheet

Author(s):  
Takayuki Hoshi ◽  
Hiroyuki Shinoda
2020 ◽  
Vol 15 (12) ◽  
pp. 1934578X2098210
Author(s):  
Nguyen Thi Nga ◽  
Do Thi Phuong ◽  
Nguyen Thi Cuc ◽  
Trieu Ha Phuong ◽  
Pham Thi Mai Huong ◽  
...  

Recently, saponins derived from marine sources have received much attention because of their promising bioactivities, such as anticancer, anti-angiogenesis, and anti-inflammation. In particular, a triterpene saponin from the sea cucumber Cercodemas anceps Selenka, cercodemasoide A (CAN1), showed potent cytotoxicity against various cancer cell lines. Recent evidence has indicated that cancer stem cells (CSCs) could be a novel target for efficient cancer therapies. In order to improve the biopharmaceutical properties of CAN1, the compound was loaded into nanoliposomes as an ideal drug carrier. CAN1 was successfully incorporated into nanoliposomes as small unilamellar liposome vesicles with an average size of 73.39 ± 1.57 nm, zeta potential of −0.299 ± 0.046 mV, polydispersity index of 0.336 ± 0.038, and with an encapsulation efficiency of up to 62.9%. For the first time, CAN1 and its nanoliposomal forms have been shown to have a promising cytotoxic activity against NTERA-2 CSCs, with half-maximal inhibitory concentration (IC50) =1.03 ± 0.04 and 0.41 ± 0.03 µM, respectively. The CAN1 nanoliposomes also presented significantly improved activities in suppressing the growth of NTERA-2 3-dimensional tumorspheres (IC50 = 1.71 ± 0.06 µM) in comparison with the free form ( P < .05). The anti-CSC effects of CAN1 nanoliposomes on NTERA-2 cells were due to their apoptotic induction through enhancing caspase-3 activity (more than 2-fold) and arresting the cell cycle at the S phase ( P < .05). The obtained CAN1-encapsulated nanoliposomes suggest valuable applications in CSC-targeting treatment for more efficient clinical therapy.


2003 ◽  
Vol 87 (Appendix) ◽  
pp. 211-212
Author(s):  
Hiroki Shinoda ◽  
Naotaka Ikemoto ◽  
Minoru Isomura

2007 ◽  
Vol 10 (4) ◽  
pp. 291-297
Author(s):  
Yasuhiko HARA ◽  
Hiromitsu IKEDA ◽  
Yoshikazu KOBAYASHI ◽  
Kenji SHIRAI

2017 ◽  
Vol 25 (20) ◽  
pp. 24727 ◽  
Author(s):  
Li Xu ◽  
Jia Ge ◽  
Jay H. Patel ◽  
Mable P. Fok

1996 ◽  
Vol 35 (11) ◽  
pp. 1341-1346 ◽  
Author(s):  
Chi-Min Liao ◽  
Gim S. Chen ◽  
Robert P. Wei

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