Early detection of fatty liver disease in mice via quantitative ultrasound

2014 ◽  
Author(s):  
Aiguo Han ◽  
John W. Erdman ◽  
Douglas G. Simpson ◽  
Michael P. Andre ◽  
William D. O'Brien
Keyword(s):  
Liver Disease ◽  
Early Detection ◽  
Fatty Liver ◽  
Quantitative Ultrasound ◽  
Fatty Liver Disease

scholarly journals Early Detection of Nonalcoholic Steatohepatitis in Patients with Nonalcoholic Fatty Liver Disease by Using MR Elastography

Radiology ◽  
2011 ◽  
Vol 259 (3) ◽  
pp. 749-756 ◽  
Author(s):  
Jun Chen ◽  
Jayant A. Talwalkar ◽  
Meng Yin ◽  
Kevin J. Glaser ◽  
Schuyler O. Sanderson ◽  
...  
Keyword(s):  
Liver Disease ◽  
Early Detection ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
Fatty Liver Disease ◽  
Mr Elastography ◽  
Nonalcoholic Fatty Liver

scholarly journals Enzyme Activity and De Ritis Ratio in Alcoholic and Non Alcoholic Fatty Liver Patients based on Ultrasonography

2020 ◽  
Vol 8 (1) ◽  
pp. 9-13
Author(s):  
Sanju Rawal ◽  
Aakash Shahi ◽  
Narayan Gautam ◽  
Archana Jayan ◽  
Uday Sharma
Keyword(s):  
Enzyme Activity ◽  
Liver Disease ◽  
Early Detection ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
P Value ◽  
Alcoholic Fatty Liver ◽  
Asymptomatic Patients ◽  
Significant Difference ◽  
Serum Glutamate

INTRODUCTION: Fatty liver disease (FLD) refers to a wide clinical and histological spectrum from simple hepatic steatosis to steatohepatitis or cirrhosis, and FLD has been classified as nonalcoholic FLD (NAFLD) and alcoholic FLD (AFLD) based on etiology and ultrasonography (USG). MATERIAL AND METHODS: This Cross-sectional study was undertaken in the Department of Radiology, Universal College of Medical Sciences (UCMS), Bhairahawa, Nepal from March 2019 to February 2020. A total of 100 subjects involved where ultrasonographically graded for fatty liver and enzyme activity were assessed to observe their association. RESULTS: In 100 cases, 66% were male and 34% were female. Ultrasonography (USG) guided FLD grade 1 patients were 81%, FLD grade 2 patients were 19% where as no cases was observed for FLD grade 3. Fifty Six percent (56%) of the total cases presented with AFLD while remaining 44% with NAFLD. There was significant difference in serum glutamate oxaloacetate transaminase (SGOT) (p-value: 0.003), serum glutamate pyruvate transaminase (SGPT) (p-value: 0.011) and alkaline phosphatase (ALP) (p-value: 0.003) in AFLD and NAFLD. However, there was no significant association of enzyme activity with FLD grade (p-value >0.05). There was significant difference in SGOT (p-value: 0.004), SGPT (p- value: 0.025) between AFLD grade 1 (AFLDG1) and NFLD grade 1 (NAFLDG1), SGOT (p-value: 0.016) between AFLDG2 and NAFLDG2 and ALP (p-value: 0.01) between AFLDG1 and NAFLDG1. However, De Ritis ratio was not significantly associated with fatty liver disease. CONCLUSION: USG is a non-invasive simple tool for early detection of fatty liver in asymptomatic patients enabling clinicians to achieve early detection in conjunction with hepatic enzymes.

Identifying nonalcoholic fatty liver disease from quantitative ultrasound measures

2018 ◽  
Vol 143 (3) ◽  
pp. 1775-1775
Author(s):  
W. D. O'Brien ◽  
Aiguo Han ◽  
Ethan Z. Sy ◽  
Rohit Loomba ◽  
Claude B. Sirlin ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Quantitative Ultrasound ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver
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