Noninvasive right ventricular pressure estimation in vivo using the subharmonic emissions from ultrasound contrast agents

2012 ◽  
Author(s):  
Jaydev K. Dave ◽  
Valgerdur G. Halldorsdottir ◽  
John R. Eisenbrey ◽  
Joel S. Raichlen ◽  
Ji-Bin Liu ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Contrast Agents ◽  
Ultrasound Contrast Agents ◽  
Ventricular Pressure ◽  
Ultrasound Contrast ◽  
Pressure Estimation

scholarly journals Subharmonic microbubble emissions for noninvasively tracking right ventricular pressures

2012 ◽  
Vol 303 (1) ◽  
pp. H126-H132 ◽  
Author(s):  
Jaydev K. Dave ◽  
Valgerdur G. Halldorsdottir ◽  
John R. Eisenbrey ◽  
Joel S. Raichlen ◽  
Ji-Bin Liu ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Contrast Agents ◽  
Acoustic Emissions ◽  
Right Heart Catheterization ◽  
Ultrasound Contrast Agents ◽  
Heart Catheterization ◽  
Ultrasound Contrast ◽  
Individual Calibration ◽  
The Individual

Right heart catheterization is often required to monitor intra-cardiac pressures in a number of disease states. Ultrasound contrast agents can produce pressure modulated subharmonic emissions that may be used to estimate right ventricular (RV) pressures. A technique based on subharmonic acoustic emissions from ultrasound contrast agents to track RV pressures noninvasively has been developed and its clinical potential evaluated. The subharmonic signals were obtained from the aorta, RV, and right atrium (RA) of five anesthetized closed-chest mongrel dogs using a SonixRP ultrasound scanner and PA4-2 phased array. Simultaneous pressure measurements were obtained using a 5-French solid state micromanometer tipped catheter. Initially, aortic subharmonic signals and systemic blood pressures were used to obtain a calibration factor in units of millimeters of mercury per decibel. This factor was combined with RA pressures (that can be obtained noninvasively) and the acoustic data from the RV to obtain RV pressure values. The individual calibration factors ranged from −2.0 to −4.0 mmHg/dB. The subharmonic signals tracked transient changes in the RV pressures within an error of 0.6 mmHg. Relative to the catheter pressures, the mean errors in estimating RV peak systolic and minimum diastolic pressures, and RV relaxation [isovolumic negative derivative of change in pressure over time (−dP/d t)] by use of the subharmonic signals, were −2.3 mmHg, −0.8 mmHg, and 2.9 mmHg/s, respectively. Overall, acoustic estimates of RV peak systolic and minimum diastolic pressures and RV relaxation were within 3.4 mmHg, 1.8 mmHg, and 5.9 mmHg/s, respectively, of the measured pressures. This pilot study demonstrates that subharmonic emissions from ultrasound contrast agents have the potential to noninvasively track in vivo RV pressures with errors below 3.5 mmHg.

scholarly journals Recent Experiences and Advances in Contrast-Enhanced Subharmonic Ultrasound

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
John R. Eisenbrey ◽  
Anush Sridharan ◽  
Ji-Bin Liu ◽  
Flemming Forsberg
Keyword(s):  
Contrast Agents ◽  
Tumor Imaging ◽  
Three Dimensional ◽  
Ultrasound Contrast Agents ◽  
Surrounding Tissue ◽  
Contrast Enhanced Ultrasound ◽  
Ultrasound Contrast ◽  
Contrast Enhanced ◽  
Subharmonic Response

Nonlinear contrast-enhanced ultrasound imaging schemes strive to suppress tissue signals in order to better visualize nonlinear signals from blood-pooling ultrasound contrast agents. Because tissue does not generate a subharmonic response (i.e., signal at half the transmit frequency), subharmonic imaging has been proposed as a method for isolating ultrasound microbubble signals while suppressing surrounding tissue signals. In this paper, we summarize recent advances in the use of subharmonic imagingin vivo. These advances include the implementation of subharmonic imaging on linear and curvilinear arrays, intravascular probes, and three-dimensional probes for breast, renal, liver, plaque, and tumor imaging.

Stabilized bubbles in the body: pressure-radius relationships and the limits to stabilization

1997 ◽  
Vol 82 (6) ◽  
pp. 2045-2053 ◽  
Author(s):  
Hugh D. Van Liew ◽  
Soumya Raychaudhuri
Keyword(s):  
Contrast Agents ◽  
Conceptual Framework ◽  
Bubble Radius ◽  
Ultrasonic Imaging ◽  
Ultrasound Contrast Agents ◽  
The Body ◽  
Strong Growth ◽  
Ultrasound Contrast ◽  
Practical Usefulness

Van Liew, Hugh D., and Soumya Raychaudhuri. Stabilized bubbles in the body: pressure-radius relationships and the limits to stabilization. J. Appl. Physiol.82(6): 2045–2053, 1997.—We previously outlined the fundamental principles that govern behavior of stabilized bubbles, such as the microbubbles being put forward as ultrasound contrast agents. Our present goals are to develop the idea that there are limits to the stabilization and to provide a conceptual framework for comparison of bubbles stabilized by different mechanisms. Gases diffuse in or out of stabilized bubbles in a limited and reversible manner in response to changes in the environment, but strong growth influences will cause the bubbles to cross a threshold into uncontrolled growth. Also, bubbles stabilized by mechanical structures will be destroyed if outside influences bring them below a critical small size. The in vivo behavior of different kinds of stabilized bubbles can be compared by using plots of bubble radius as a function of forces that affect diffusion of gases in or out of the bubble. The two ends of the plot are the limits for unstabilized growth and destruction; these and the curve’s slope predict the bubble’s practical usefulness for ultrasonic imaging or O2 carriage to tissues.

In vivo observation of urinary reflux using ultrasound contrast agents

1993 ◽  
Vol 28 (12) ◽  
pp. 1182 ◽  
Author(s):  
J. A. Ivey ◽  
J. B. Fowlkes ◽  
E. A. Gardner ◽  
W. F.J. Feitz ◽  
D. A. Bloom ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Contrast Agents ◽  
Ultrasound Contrast

Characteristics and Echogenicity of Clinical Ultrasound Contrast Agents: An In Vitro and In Vivo Comparison Study

2017 ◽  
Vol 36 (5) ◽  
pp. 941-953 ◽  
Author(s):  
Jean-Marc Hyvelin ◽  
Emmanuel Gaud ◽  
Maria Costa ◽  
Alexandre Helbert ◽  
Philippe Bussat ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Contrast Agents ◽  
Comparison Study ◽  
Ultrasound Contrast

Ultrasound contrast agents in an in vivo murine melanoma model

2008 ◽  
Vol 123 (5) ◽  
pp. 3112-3112 ◽  
Author(s):  
François Tranquart ◽  
Ayache Bouakaz ◽  
Sophie Serriere
Keyword(s):  
Contrast Agents ◽  
Ultrasound Contrast Agents ◽  
Murine Melanoma ◽  
Ultrasound Contrast ◽  
Melanoma Model
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