Initial in vivo feasibility of a pre-clinical focused ultrasound system applied to blood-brain barrier opening in monkeys

2011 ◽  
Author(s):  
Fabrice Marquet ◽  
Yao-Sheng Tung ◽  
Tobias Teichert ◽  
Vincent Ferrera ◽  
Elisa E. Konofagou
Keyword(s):  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Blood Brain ◽  
Ultrasound System ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

scholarly journals Targeting Effects on the Volume of the Focused Ultrasound-Induced Blood–Brain Barrier Opening in Nonhuman Primates In Vivo

2017 ◽  
Vol 64 (5) ◽  
pp. 798-810 ◽  
Author(s):  
Maria Eleni Marilena Karakatsani ◽  
Gesthimani Mania Samiotaki ◽  
Matthew E. Downs ◽  
Vincent P. Ferrera ◽  
Elisa E. Konofagou
Keyword(s):  
Blood Brain Barrier ◽  
Nonhuman Primates ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

scholarly journals Focused ultrasound blood brain barrier opening mediated delivery of MRI-visible albumin nanoclusters to the rat brain for localized drug delivery with temporal control

2019 ◽  
Author(s):  
Megan C. Rich ◽  
Jennifer Sherwood ◽  
Aundrea F. Bartley ◽  
Quentin A. Whitsitt ◽  
W.R. Willoughby ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Rat Brain ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Temporal Specificity ◽  
Blood Brain ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

AbstractThere is an ongoing need for noninvasive tools to manipulate brain activity with molecular, spatial and temporal specificity. Here we have investigated the use of MRI-visible, albumin-based nanoclusters for noninvasive, localized and temporally specific drug delivery to the rat brain. We demonstrated that IV injected nanoclusters could be deposited into target brain regions via focused ultrasound facilitated blood brain barrier opening. We showed that nanocluster location could be confirmed in vivo with MRI. Additionally, following confirmation of nanocluster delivery, release of the nanocluster payload into brain tissue can be triggered by a second focused ultrasound treatment performed without circulating microbubbles. Release of glutamate from nanoclusters in vivo caused enhanced c-Fos expression, indicating that the loading capacity of the nanoclusters is sufficient to induce neuronal activation. This novel technique for noninvasive stereotactic drug delivery to the brain with temporal specificity could provide a new way to study brain circuits in vivo preclinically with high relevance for clinical translation.Graphical Abstract

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