High frequency ultrasound computed tomography for small animal imaging applications

2011 ◽  
Author(s):  
Wei-Tsen Chen ◽  
Cho-Chiang Shih ◽  
Chih-Chung Huang
Keyword(s):  
Computed Tomography ◽  
High Frequency ◽  
Small Animal Imaging ◽  
Small Animal ◽  
High Frequency Ultrasound ◽  
Ultrasound Computed Tomography ◽  
Animal Imaging ◽  
Frequency Ultrasound

scholarly journals High-Frequency Ultrasound Imaging to Evaluate Liver Fibrosis Progression in Rats and Yi Guan Jian Herbal Therapeutic Effects

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Wei Chen ◽  
Jiun-Yu Chen ◽  
Yu-Tang Tung ◽  
Hsiao-Ling Chen ◽  
Chia-Wen Kuo ◽  
...  
Keyword(s):  
Animal Models ◽  
Liver Fibrosis ◽  
Hepatic Fibrosis ◽  
High Frequency ◽  
Small Animal ◽  
Therapeutic Effects ◽  
High Frequency Ultrasound ◽  
Fibrosis Progression ◽  
Small Animal Models ◽  
Frequency Ultrasound

The animals used in liver fibrosis studies must usually be sacrificed. Ultrasound has been demonstrated to have the ability to diagnose hepatic fibrosis and cirrhosis in experimental small-animal models. However, few studies have used high-frequency ultrasound (HFU, 40 MHz) to monitor changes in the rat liver and other hollow organs longitudinally. In this study, liver fibrosis was induced by administering dimethylnitrosamine (DMN) in SD rats, aged 8 weeks, for three consecutive days per week for up to 4 weeks. A Chinese herbal medicine Yi Guan Jian (YGJ) was orally administered (1.8 g/kg daily) to DMN-induced liver fibrosis rats for 2 weeks. Compared with the normal control rats, rats treated with DMN for either 2 weeks or 4 weeks had significantly lower body weights, liver indexes and elevation of hydroxyproline, GOT, and GPT contents. YGJ herbal treatment remarkably prevented rats from DMN-induced liver fibrosis. The HFU scoring results among the normal controls, 2-week DMN-treated rats, 4-week DMN-treated rats, and combined 2-week YGJ therapy with 4-week DMN-treated rats also reached statistical significance. Thus, HFU is an accurate tool for the longitudinal analysis of liver fibrosis progression in small-animal models, and the YGJ may be useful in reversing the development of hepatic fibrosis.

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