MEMS-based multiple fourier-horn silicon ultrasonic atomizer for inhalation drug delivery

2011 ◽  
Author(s):  
Chen S. Tsai ◽  
Rong W. Mao ◽  
Shih K. Lin ◽  
Eric Chien ◽  
Shirley C. Tsai
Keyword(s):  
Drug Delivery ◽  
Inhalation Drug Delivery

scholarly journals MEMS-based silicon ultrasonic twin-nozzle nebulizer for inhalation drug delivery

2014 ◽  
Author(s):  
R.W. Mao ◽  
S.K. Lin ◽  
S.C. Tsai ◽  
M. Brenner ◽  
S. Mahon ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inhalation Drug Delivery

scholarly journals Inhalation drug delivery devices: technology update

2015 ◽  
pp. 131 ◽  
Author(s):  
Lucila Garcia-Contreras ◽  
Mariam Ibrahim ◽  
Rahul Verma
Keyword(s):  
Drug Delivery ◽  
Inhalation Drug Delivery ◽  
Drug Delivery Devices

scholarly journals Faraday instability-based micro droplet ejection for inhalation drug delivery

TECHNOLOGY ◽  
2014 ◽  
Vol 02 (01) ◽  
pp. 75-81 ◽  
Author(s):  
C.S. Tsai ◽  
R.W. Mao ◽  
S.K. Lin ◽  
Y. Zhu ◽  
S.C. Tsai
Keyword(s):  
Drug Delivery ◽  
Resonance Effect ◽  
High Growth ◽  
High Growth Rate ◽  
Drive Power ◽  
New Device ◽  
Faraday Instability ◽  
Inhalation Drug Delivery ◽  
Pulmonary Drugs ◽  
Silicon Based

We report here the technology and the underlying science of a new device for inhalation (pulmonary) drug delivery which is capable of fulfilling needs unmet by current commercial devices. The core of the new device is a centimeter-size clog-free silicon-based ultrasonic nozzle with multiple Fourier horns in resonance at megahertz (MHz) frequency. The dramatic resonance effect among the multiple horns and high growth rate of the MHz Faraday waves excited on a medicinal liquid layer together facilitate ejection of monodisperse droplets of desirable size range (2–5 μm) at low electrical drive power (<1.0 W). The small nozzle requiring low drive power has enabled realization of a pocket-size (8.6 × 5.6 × 1.5 cm3) ultrasonic nebulizer. A variety of common pulmonary drugs have been nebulized using the pocket-size unit with desirable aerosol sizes and output rate. These results clearly provide proof-of-principle for the new device and confirm its potential for commercialization.

1202 Investigation of the particle motion in inhalation drug delivery

2014 ◽  
Vol 2014 (0) ◽  
pp. _1202-1_-_1202-2_
Author(s):  
Sho Yoshizaki ◽  
Hiroyuki HIRAHARA ◽  
Masanori NAKAMURA
Keyword(s):  
Drug Delivery ◽  
Particle Motion ◽  
Inhalation Drug Delivery

scholarly journals Development of MPC-DPA polymeric nanoparticle systems for inhalation drug delivery applications

2017 ◽  
Vol 106 ◽  
pp. 362-380 ◽  
Author(s):  
Abdul Khaliq Elzhry Elyafi ◽  
Guy Standen ◽  
Steven T. Meikle ◽  
Andrew L. Lewis ◽  
Jonathan P. Salvage
Keyword(s):  
Drug Delivery ◽  
Polymeric Nanoparticle ◽  
Inhalation Drug Delivery ◽  
Drug Delivery Applications
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