P6C-3 Quantitative Ultrasonography Of Choroidal Melanoma Following Proton-Beam Radiotherapy

2007 ◽  
Author(s):  
M. Boudinet ◽  
J.-Y. Le Huerou ◽  
P. Laugier ◽  
O. Berges ◽  
L. Lumbroso-Lerouic ◽  
...  
Keyword(s):  
Proton Beam ◽  
Choroidal Melanoma ◽  
Proton Beam Radiotherapy ◽  
Quantitative Ultrasonography

OCT changes in peri-tumour normal retina following ruthenium-106 and proton beam radiotherapy for uveal melanoma

2020 ◽  
pp. bjophthalmol-2019-314802
Author(s):  
Rumana Hussain ◽  
Florian Moritz Heussen ◽  
Heinrich Heimann
Keyword(s):  
Proton Beam ◽  
Uveal Melanoma ◽  
Choroidal Melanoma ◽  
Retinal Layer ◽  
Proton Beam Radiotherapy ◽  
Retinal Layers ◽  
Spectral Domain Oct ◽  
Ruthenium 106 Brachytherapy ◽  
Safety Margins ◽  
Plaque Brachytherapy

IntroductionUveal melanoma is most commonly treated with radiotherapy, destroying the tumour cells with adequate safety margins and limiting collateral damage to surrounding structures to preserve maximal vision. We used optical coherence tomography (OCT) to study the effects of radiotherapy on the retina.MethodsPatients with posteriorly located choroidal melanoma treated with proton beam radiotherapy (PBR) and ruthenium-106 brachytherapy between January 2010 and June 2014 underwent spectral domain OCT.ResultsImages of 32 patients following ruthenium-106 brachytherapy and 44 patients following proton beam teletherapy were analysed. Following plaque brachytherapy, an early marked disruption of the outer retinal layers could be observed in 30 cases (94%) with retinal atrophy evident in 26 cases (81%). In contrast, the images from patients who underwent PBR showed subtle outer retinal layer change with 16 cases (36%) showing some inner-outer segment junction disruption by 6 months and 63%  by 24 months with minimal atrophy. In cases with tumours <2 mm from the fovea, the visual loss was significantly less at 6 and 12 months in the proton beam group.ConclusionIn comparison to ruthenium-106 plaque brachytherapy, PBR leads to more subtle and slower changes in the outer retinal layers enabling retention of visual function for longer. The difference in dosing regime and dose distribution across the tumour is likely to be causative for this structural differential.

scholarly journals Ultra-wide-field imaging of choroidal melanoma before and after proton beam radiation therapy

2019 ◽  
Vol 30 (6) ◽  
pp. 1397-1402
Author(s):  
Angeliki Psomiadi ◽  
Gertrud Haas ◽  
Michael Edlinger ◽  
Nikolaos E Bechrakis ◽  
Georgios Blatsios
Keyword(s):  
Proton Beam ◽  
Choroidal Melanoma ◽  
Subretinal Fluid ◽  
Scanning Laser ◽  
Wide Field ◽  
Scanning Laser Ophthalmoscopy ◽  
Proton Beam Radiotherapy ◽  
Imaging Characteristics ◽  
Before And After

Objective: To evaluate the imaging characteristics of choroidal melanoma before and after proton beam radiotherapy via Optos® ultra-wide-field scanning laser ophthalmoscopy. Methods: Retrospective, descriptive study of choroidal melanoma patients treated with proton beam radiotherapy. All patients underwent full clinical evaluation, including best-corrected visual acuity, ultrasound examination and ultra-wide-field scanning laser ophthalmoscopy imaging in the pseudo-colour (red and green channel) as well as auto-fluorescence mode. Tumours were classified and evaluated according to their location, size, presence of subretinal fluid, drusen, orange pigment and reflectance intensity in ultra-wide-field scanning laser ophthalmoscopy. Tumour sonographic (basal diameter, height) and ultra-wide-field scanning laser ophthalmoscopy imaging dimensions (maximal diameter) were documented. Results: A total of 39 eyes (38 patients) were followed for 24 months (range 6–48 months). Mean best-corrected visual acuity dropped from 20/40 to 20/63 after proton beam radiotherapy. There was no change in the imaging tumour characteristics during follow-up. Subretinal fluid changes were better detected in the autofluorescence compared to pseudo-colour mode. Mean tumour diameter did not significantly change in the ultra-wide-field scanning laser ophthalmoscopy although it did so in the ultrasound. No patient showed local tumour recurrence. Conclusion: The ultra-wide-field scanning laser ophthalmoscopy imaging characteristics of choroidal melanoma in the Optos® system do not significantly change after proton beam radiotherapy after a mean follow-up of 2 years.

Trans-scleral local resection of toxic choroidal melanoma after proton beam radiotherapy

2014 ◽  
Vol 98 (6) ◽  
pp. 775-779 ◽  
Author(s):  
Lazaros Konstantinidis ◽  
Carl Groenewald ◽  
Sarah E Coupland ◽  
Bertil Damato
Keyword(s):  
Proton Beam ◽  
Choroidal Melanoma ◽  
Local Resection ◽  
Proton Beam Radiotherapy

Proton beam radiotherapy of choroidal melanoma: The Liverpool-Clatterbridge experience

2005 ◽  
Vol 62 (5) ◽  
pp. 1405-1411 ◽  
Author(s):  
Bertil Damato ◽  
Andrzej Kacperek ◽  
Mona Chopra ◽  
Ian R. Campbell ◽  
R. Douglas Errington
Keyword(s):  
Proton Beam ◽  
Choroidal Melanoma ◽  
Proton Beam Radiotherapy

scholarly journals Treated Choroidal Melanoma with Late Metastases to the Contralateral Orbit

2009 ◽  
Vol 2 ◽  
pp. CPath.S767 ◽  
Author(s):  
Sonia George ◽  
Carole A. Cooke ◽  
Gerald F. Mc Ginnity ◽  
Steve White ◽  
Laksmi Venkatraman
Keyword(s):  
Proton Beam ◽  
Choroidal Melanoma ◽  
Metastatic Spread ◽  
Proton Beam Radiotherapy ◽  
Secondary Spread

Choroidal melanoma is the commonest adult primary intraocular tumour, 1 and usual sites of secondary spread are to liver, bone and lung. Although delayed recurrence of ipsilateral orbital melanoma is well documented, metastasis to the contralateral orbit is a rarely encountered phenomenon. We describe a case of metastatic spread to the contralateral orbit in a patient 12 years after proton beam radiotherapy of choroidal melanoma.

Breakdown of the blood-eye barrier in choroidal melanoma after proton beam radiotherapy

2019 ◽  
Vol 257 (10) ◽  
pp. 2323-2328 ◽  
Author(s):  
Annette Hager ◽  
Friederike Meissner ◽  
Aline–Isabel Riechardt ◽  
Theresa Bonaventura ◽  
Julia Löwen ◽  
...  
Keyword(s):  
Proton Beam ◽  
Choroidal Melanoma ◽  
Proton Beam Radiotherapy
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