scholarly journals Microbubble Composition and Preparation for High-Frequency Contrast-Enhanced Ultrasound Imaging: In Vitro and In Vivo Evaluation

2017 ◽  
Vol 64 (3) ◽  
pp. 555-567 ◽  
Author(s):  
Verya Daeichin ◽  
Tom van Rooij ◽  
Ilya Skachkov ◽  
Bulent Ergin ◽  
Patricia A. C. Specht ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
High Frequency ◽  
Contrast Enhanced Ultrasound ◽  
In Vivo Evaluation ◽  
Contrast Enhanced

scholarly journals Ultrasound-Based Molecular Imaging of Tumors with PTPmu Biomarker-Targeted Nanobubble Contrast Agents

2021 ◽  
Vol 22 (4) ◽  
pp. 1983
Author(s):  
Mette L. Johansen ◽  
Reshani Perera ◽  
Eric Abenojar ◽  
Xinning Wang ◽  
Jason Vincent ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Imaging Modality ◽  
Tyrosine Phosphatase ◽  
Receptor Protein ◽  
Contrast Enhanced Ultrasound ◽  
Core Lipid ◽  
Contrast Enhanced

Ultrasound imaging is a widely used, readily accessible and safe imaging modality. Molecularly-targeted microbubble- and nanobubble-based contrast agents used in conjunction with ultrasound imaging expand the utility of this modality by specifically targeting and detecting biomarkers associated with different pathologies including cancer. In this study, nanobubbles directed to a cancer biomarker derived from the Receptor Protein Tyrosine Phosphatase mu, PTPmu, were evaluated alongside non-targeted nanobubbles using contrast enhanced ultrasound both in vitro and in vivo in mice. In vitro resonant mass and clinical ultrasound measurements showed gas-core, lipid-shelled nanobubbles conjugated to either a PTPmu-directed peptide or a Scrambled control peptide were equivalent. Mice with heterotopic human tumors expressing the PTPmu-biomarker were injected with PTPmu-targeted or control nanobubbles and dynamic contrast-enhanced ultrasound was performed. Tumor enhancement was more rapid and greater with PTPmu-targeted nanobubbles compared to the non-targeted control nanobubbles. Peak tumor enhancement by the PTPmu-targeted nanobubbles occurred within five minutes of contrast injection and was more than 35% higher than the Scrambled nanobubble signal for the subsequent two minutes. At later time points, the signal in tumors remained higher with PTPmu-targeted nanobubbles demonstrating that PTPmu-targeted nanobubbles recognize tumors using molecular ultrasound imaging and may be useful for diagnostic and therapeutic purposes.

High-Frequency Nonlinear Doppler Contrast-Enhanced Ultrasound Imaging of Blood Flow

2020 ◽  
Vol 67 (9) ◽  
pp. 1776-1784 ◽  
Author(s):  
Matthew Bruce ◽  
Alex Hannah ◽  
Ryan Hammond ◽  
Zin Z. Khaing ◽  
Charles Tremblay-Darveau ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ultrasound Imaging ◽  
High Frequency ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

scholarly journals Contrast-Enhanced Ultrasound Imaging and in Vivo Circulatory Kinetics with Low-Boiling-Point Nanoscale Phase-Change Perfluorocarbon Agents

2015 ◽  
Vol 41 (3) ◽  
pp. 814-831 ◽  
Author(s):  
Paul S. Sheeran ◽  
Juan D. Rojas ◽  
Connor Puett ◽  
Jordan Hjelmquist ◽  
Christopher B. Arena ◽  
...  
Keyword(s):  
Phase Change ◽  
Ultrasound Imaging ◽  
Boiling Point ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced
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