Bactericidal Action of the Reactive Species Produced by Gas-Discharge Nonthermal Plasma at Atmospheric Pressure: A Review

2006 ◽  
Vol 34 (4) ◽  
pp. 1257-1269 ◽  
Author(s):  
L.F. Gaunt ◽  
C.B. Beggs ◽  
G.E. Georghiou
Keyword(s):  
Atmospheric Pressure ◽  
Nonthermal Plasma ◽  
Gas Discharge ◽  
Reactive Species ◽  
Bactericidal Action

Atmospheric-pressure, nonthermal plasma sterilization of microorganisms in liquids and on surfaces

2008 ◽  
Vol 80 (9) ◽  
pp. 1953-1969 ◽  
Author(s):  
Yuri Akishev ◽  
Michail Grushin ◽  
Vladimir Karalnik ◽  
Nickolay Trushkin ◽  
Vasiliy Kholodenko ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Gas Flow ◽  
Discharge Plasma ◽  
Nonthermal Plasma ◽  
Gas Discharge ◽  
Plasma Sources ◽  
Plasma Sterilization ◽  
Gas Discharge Plasma ◽  
Promising Area ◽  
Widespread Interest

Gas discharge plasma inactivation of microorganisms at low (close to ambient) temperature is a promising area of investigation that is attracting widespread interest. This paper describes atmospheric-pressure, nonthermal plasma (NTP) methods for cold sterilization of liquids and thermal sensitive surfaces. These methods are based on the use of direct current (DC) gas discharge plasma sources fed with steady-state high voltage. Parameters characterizing the plasma sources used (plasma-forming gas, gas flow rate, electric power consumed, etc.) are given. The results for plasma sterilization of different microorganisms (vegetative cells, spores, fungi, biofilms) are presented. An empirical mathematical approach is developed for describing NTP inactivation of microorganisms. This approach takes into account not only the destruction of different components of the cells, but their reparation as well.

Experimental Evidences on Synergy of Gas Discharge Agents in Bactericidal Activity of Nonthermal Plasma

2013 ◽  
Vol 3 (1-2) ◽  
pp. 137-152 ◽  
Author(s):  
Elena V. Sysolyatina ◽  
Andrey Mukhachev ◽  
Maria Yurova ◽  
Mikhail Grushin ◽  
Vladimir Karal'nik ◽  
...  
Keyword(s):  
Bactericidal Activity ◽  
Nonthermal Plasma ◽  
Gas Discharge

Reactivity of methane in nonthermal plasma in the presence of oxygen and inert gases at atmospheric pressure

2001 ◽  
Vol 37 (6) ◽  
pp. 1618-1624 ◽  
Author(s):  
M. Okumoto ◽  
Hyun Ha Kim ◽  
K. Takashima ◽  
S. Katsura ◽  
A. Mizuno
Keyword(s):  
Atmospheric Pressure ◽  
Nonthermal Plasma ◽  
Inert Gases

A Dusty Plasma in a Non-Self-Sustained Gas Discharge at Atmospheric Pressure

2016 ◽  
Vol 56 (3-4) ◽  
pp. 286-295 ◽  
Author(s):  
A. V. Fiippov ◽  
V. N. Babichev ◽  
A. F. Pal' ◽  
A. N. Starostin ◽  
V. E. Cherkovets
Keyword(s):  
Dusty Plasma ◽  
Atmospheric Pressure ◽  
Gas Discharge

scholarly journals Analysis of Plasma-activated Medium (PAM) in aqueous solution by an Atmospheric Pressure Plasma Jet (APPJ)

2018 ◽  
Vol 197 ◽  
pp. 02013 ◽  
Author(s):  
Andi Wibowo Kinandana ◽  
Sumariyah Sumariyah ◽  
Muhammad Nur
Keyword(s):  
Hydrogen Peroxide ◽  
Species Composition ◽  
Exposure Time ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Plasma Jet ◽  
Reactive Species ◽  
Atmospheric Pressure Plasma Jet ◽  
Liquid Media ◽  
Pressure Plasma

Plasma-activated medium (PAM) has been produced by exposing a liquid media to Argon plasma jet. The jet plasma exposure to liquid media has produced reactive Oxygen species (ROS) in liquid phase. This study aims to determine the number of reactive species in plasma-activated medium. An atmospheric pressure plasma jet (APPJ) was generated with a dielectric barrier discharge (DBD) column by AC high voltage. Some parameters varied including exposure time; i.e. 5, 10, 15, 20, 25, and 30 min; and the distance between reactor and active media; i.e. 1, 2 and 3 cm. Some analysis conducted including variation of exposure times, the distances of reactor to PAM which affect produced concentration, and the reactive species composition in plasma-activated medium. In addition, temperature characteristics, pH levels, dissolved ozone and dissolved hydrogen peroxide concentrations were also observed in this study. The results showed that increased exposure time resulted in decreased pH, increased temperature and increased concentrations of ozone and hydrogen peroxide. The maximum reactive species composition was obtained at the distance between reactor and plasma-activated medium of 2 cm. Maximum reactive species composition obtained in this study has temperature of 29-30 Celsius degrees; pH 3.5; dissolved ozone 2.97 ppm; and Hydrogen Peroxide 215 ppm.

scholarly journals Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment

2020 ◽  
Vol 10 (19) ◽  
pp. 6898
Author(s):  
Lars Boeckmann ◽  
Mirijam Schäfer ◽  
Thoralf Bernhardt ◽  
Marie Luise Semmler ◽  
Ole Jung ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Reactive Species ◽  
Therapeutic Effects ◽  
Preclinical Research ◽  
Pressure Plasma ◽  
Cold Atmospheric Pressure Plasma

Plasma medicine is gaining increasing attention and is moving from basic research into clinical practice. While areas of application are diverse, much research has been conducted assessing the use of cold atmospheric pressure plasma (CAP) in wound healing and cancer treatment—two applications with entirely different goals. In wound healing, a tissue-stimulating effect is intended, whereas cancer therapy aims at killing malignant cells. In this review, we provide an overview of the latest clinical and some preclinical research on the efficacy of CAP in wound healing and cancer therapy. Furthermore, we discuss the current understanding of molecular signaling mechanisms triggered by CAP that grant CAP its antiseptic and tissue regenerating or anti-proliferative and cell death-inducing properties. For the efficacy of CAP in wound healing, already substantial evidence from clinical studies is available, while evidence for therapeutic effects of CAP in oncology is mainly from in vitro and in vivo animal studies. Efforts to elucidate the mode of action of CAP suggest that different components, such as ultraviolet (UV) radiation, electromagnetic fields, and reactive species, may act synergistically, with reactive species being regarded as the major effector by modulating complex and concentration-dependent redox signaling pathways.

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