Thermal Properties of Magnetic Nanoparticles Modified With Polyethylene Glycol

2013 ◽  
Vol 49 (1) ◽  
pp. 236-239 ◽  
Author(s):  
Alena Jurikova ◽  
Kornel Csach ◽  
Jozef Miskuf ◽  
Martina Koneracka ◽  
Vlasta Zavisova ◽  
...  
Keyword(s):  
Thermal Properties ◽  
Polyethylene Glycol ◽  
Magnetic Nanoparticles

Co-delivery of Doxorubicin and D-α-Tocopherol Polyethylene Glycol 1000 Succinate by Magnetic Nanoparticles

2018 ◽  
Vol 18 (8) ◽  
pp. 1138-1147 ◽  
Author(s):  
Esra Metin ◽  
Pelin Mutlu ◽  
Ufuk Gündüz
Keyword(s):  
Breast Cancer ◽  
Polyethylene Glycol ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Drug Loading ◽  
Gravimetric Analysis ◽  
Polyethylene Glycol 1000 ◽  
Mcf 7

Background: Although conventional chemotherapy is the most common method for cancer treatment, it has several side effects such as neuropathy, alopecia and cardiotoxicity. Since the drugs are given to body systemically, normal cells are also affected, just like cancer cells. However, in recent years, targeted drug delivery has been developed to overcome these drawbacks. Objective: The aim of this study was targeted co-delivery of doxorubicin (Dox) which is an anticancer agent and D-α-Tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS or simply TPGS) to breast cancer cells. For this purpose, Magnetic Nanoparticles (MNPs) were synthesized and coated with Oleic Acid (OA). Coated nanoparticles were encapsulated in Poly Lactic-co-Glycolic Acid (PLGA) and TPGS polymers and loaded with Dox. The Nanoparticles (NPs) were characterized by Fourier Transform Infrared (FTIR) spectroscopy, zetapotential analysis, Dynamic Light Scattering (DLS) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscope (SEM) analysis. Results: The results showed that NPs were spherical, superparamagnetic and in the desired range for use in drug targeting. The targetability of NPs was confirmed. Moreover, TPGS and Dox loading was shown by TGA and FTIR analyses. NPs were internalized by cells and the cytotoxic effect of drug loaded NPs on sensitive (MCF-7) and drug-resistant (MCF-7/Dox) cells were examined. It was seen that the presence of TPGS increased cytotoxicity significantly. TPGS also enhanced drug loading efficiency, release rate, cellular internalization. In MCF- 7/Dox cells, the drug resistance seems to be decreased when Dox is loaded onto TPGS containing NPs. Conclusion: This magnetic PLGA nanoparticle system is important for new generation targeted chemotherapy and could be used for breast cancer treatment after in vivo tests.

Characterization of Nostoc muscorum NCCU-442 Derived Poly-3- hydroxybutyrate (PHB) and Polyethylene Glycol (PEG) Blends

2020 ◽  
Vol 10 (3) ◽  
pp. 200-207
Author(s):  
Sabbir Ansari ◽  
Tasneem Fatma
Keyword(s):  
Thermal Properties ◽  
Polyethylene Glycol ◽  
Morphological Properties ◽  
Morphological Alteration ◽  
Nostoc Muscorum ◽  
Microbial Culture ◽  
Polymer Science ◽  
Mixed Microbial Culture ◽  
Scanning Calorimetry ◽  
Casting Technique

Background: Poly-3-hydroxybutyrate (PHB) has attracted much consideration as biodegradable biocompatible polymer. This thermoplastic polymer has comparable material properties to polypropylene. Materials with more valuable properties may result from blending, a common practice in polymer science. Objective: In this paper, blends of PHB (extracted from cyanobacterium Nostoc muscorum NCCU- 442 with polyethylene glycol (PEG) were investigated for their thermal, tensile, hydrophilic and biodegradation properties. Methods: Blends were prepared in different proportions of PHB/PEG viz. 100/0, 98/2, 95/5, 90/10, 80/20, and 70/30 (wt %) using solvent casting technique. Morphological properties were investigated by using Scanning Electron Microscopy (SEM). Differential scanning calorimetry and thermogravimetric analysis were done for thermal properties determination whereas the mechanical and hydrophilic properties of the blends were studied by means of an automated material testing system and contact angle analyser respectively. Biodegradability potential of the blended films was tested as percent weight loss by mixed microbial culture within 60 days. Results: The blends showed good misciblity between PEG and PHB, however increasing concentrations of plasticizer caused morphological alteration as evidenced by SEM micrographs. PEG addition (10 % and above) showed significant alternations in the thermal properties of the blends. Increase in the PEG content increased the elongation at break ratio i.e enhanced the required plasticity of PHB. Rate of microbial facilitated degradation of the blends was greater with increasing PEG concentrations. Conclusion: Blending with PEG increased the crucial polymeric properties of cyanobacterial PHB.

Preparation and Thermal Propertites of Polyethylene Glycol/ Silica Hollow Nanospheres Composite as Shape-Stabilized Phase Change Materials

2013 ◽  
Vol 773 ◽  
pp. 534-537 ◽  
Author(s):  
Li Li Feng ◽  
Jing Jing Tong ◽  
Chong Yun Wang
Keyword(s):  
Thermal Properties ◽  
Polyethylene Glycol ◽  
Phase Change ◽  
Porous Structure ◽  
Phase Change Materials ◽  
Hollow Nanospheres ◽  
Lower Phase ◽  
Phase Change Temperature ◽  
Change Temperature ◽  
Change Material

Shape-stabilized phase change material (PCM) composed of polyethylene glycol and silica hollow nanospheres was prepared by a vacuum impregnating method. Thermal properties of the composite PCM were investigated by various techniques. Lower phase change temperature and enthalpy of the composite PCM were observed. It is concluded that the phase change properties of the composite PCM are influenced by the adsorption confinement of the PEG segments from the porous structure of the silica hollow nanospheres.

Measurement of thermal properties of magnetic nanoparticles using infrared thermal microscopy

2013 ◽  
Vol 57 ◽  
pp. 76-80 ◽  
Author(s):  
Jae Young Kim ◽  
Ki Soo Chang ◽  
Myung Ho Kook ◽  
Seon Young Ryu ◽  
Hae Young Choi ◽  
...  
Keyword(s):  
Thermal Properties ◽  
Magnetic Nanoparticles ◽  
Thermal Microscopy

Thermal properties of nano-sized polyethylene glycol confined in silica gels for latent heat storage

2017 ◽  
Vol 655 ◽  
pp. 211-218 ◽  
Author(s):  
Fang Tian ◽  
Shiqi Zhang ◽  
Min Zhai ◽  
Jian Sui ◽  
Xiaozheng Lan ◽  
...  
Keyword(s):  
Thermal Properties ◽  
Polyethylene Glycol ◽  
Latent Heat ◽  
Heat Storage ◽  
Silica Gels ◽  
Latent Heat Storage

Study on the Properties of Poly(lactic Acid) and Thermal Plastic Starch Blended Materials Plasticized by PEG 200

2012 ◽  
Vol 550-553 ◽  
pp. 813-817 ◽  
Author(s):  
Peng Liu ◽  
Cai Qin Gu ◽  
Qing Zhu Zeng ◽  
Hao Huai Liu
Keyword(s):  
Lactic Acid ◽  
Thermal Properties ◽  
Polyethylene Glycol ◽  
Rheological Properties ◽  
Tensile Properties ◽  
Tensile Modulus ◽  
Poly Lactic Acid ◽  
Pseudoplastic Fluid ◽  
Materials Properties ◽  
Plasticization Effect

In this paper, the blended materials of poly(lactic acid) (PLA) and thermal plastic starch (TPS) under the plasticization of polyethylene glycol (PEG) 200 were prepared. By detecting the thermal, rheological and tensile properties, it evaluated the plasticization effect of PEG 200 on blended materials. Specifically, for thermal properties, the addition of PEG 200 could improve mobile ability of PLA macromolecules, and accelerated them to form crystalline. But if the content of PEG 200 was more than 10%, this effect was impaired. For rheological properties, PEG 200 could change the fusant of blended materials from pseudoplastic fluid to newton fluid. However, if the PEG 200 was added too much, the blended material was too like perfect newton fluid to be prepared suitably. For tensile properties, when content of PEG 200 was more than 10%, the elongation and tensile modulus would changed sharply. All in all, 10% was the suitable addition parameter for PEG 200. Above this content, the plasticization effect of PEG 200 was too strong to impaired materials properties.

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