Optimizing Quality for Probabilistic Skyline Computation and Probabilistic Similarity Search

2018 ◽  
Vol 30 (9) ◽  
pp. 1741-1755 ◽  
Author(s):  
Xiaoye Miao ◽  
Yunjun Gao ◽  
Linlin Zhou ◽  
Wei Wang ◽  
Qing Li
Keyword(s):  
Similarity Search ◽  
Probabilistic Skyline

Similarity Search in Data Stream with Adaptive Segmental Approximations

2009 ◽  
Vol 20 (10) ◽  
pp. 2867-2884 ◽  
Author(s):  
Feng WU ◽  
Yan ZHONG ◽  
Quan-Yuan WU ◽  
Yan JIA ◽  
Shu-Qiang YANG
Keyword(s):  
Similarity Search ◽  
Data Stream

Combined QSAR Model and Chemical Similarity Search for Novel HMG-CoA Reductase Inhibitors for Coronary Heart Disease

2020 ◽  
Vol 16 (4) ◽  
pp. 473-485
Author(s):  
David Mary Rajathei ◽  
Subbiah Parthasarathy ◽  
Samuel Selvaraj
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Similarity Search ◽  
Qsar Model ◽  
Chemical Similarity ◽  
Cholesterol Accumulation ◽  
Reductase Inhibitors ◽  
Pubchem Database ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase

Background: Coronary heart disease generally occurs due to cholesterol accumulation in the walls of the heart arteries. Statins are the most widely used drugs which work by inhibiting the active site of 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) enzyme that is responsible for cholesterol synthesis. A series of atorvastatin analogs with HMGCR inhibition activity have been synthesized experimentally which would be expensive and time-consuming. Methods: In the present study, we employed both the QSAR model and chemical similarity search for identifying novel HMGCR inhibitors for heart-related diseases. To implement this, a 2D QSAR model was developed by correlating the structural properties to their biological activity of a series of atorvastatin analogs reported as HMGCR inhibitors. Then, the chemical similarity search of atorvastatin analogs was performed by using PubChem database search. Results and Discussion: The three-descriptor model of charge (GATS1p), connectivity (SCH-7) and distance (VE1_D) of the molecules is obtained for HMGCR inhibition with the statistical values of R2= 0.67, RMSEtr= 0.33, R2 ext= 0.64 and CCCext= 0.76. The 109 novel compounds were obtained by chemical similarity search and the inhibition activities of the compounds were predicted using QSAR model, which were close in the range of experimentally observed threshold. Conclusion: The present study suggests that the QSAR model and chemical similarity search could be used in combination for identification of novel compounds with activity by in silico with less computation and effort.

Continuous Probabilistic Skyline Query for Secure Worker Selection in Mobile Crowdsensing

2021 ◽  
pp. 1-1
Author(s):  
Xichen Zhang ◽  
Rongxing Lu ◽  
Jun Shao ◽  
Hui Zhu ◽  
Ali A. Ghorbani
Keyword(s):  
Skyline Query ◽  
Mobile Crowdsensing ◽  
Worker Selection ◽  
Probabilistic Skyline
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