A Critical-Time-Point Approach to All-Departure-Time Lagrangian Shortest Paths

2015 ◽  
Vol 27 (10) ◽  
pp. 2591-2603 ◽  
Author(s):  
Venkata M.V. Gunturi ◽  
Shashi Shekhar ◽  
KwangSoo Yang
Keyword(s):  
Shortest Paths ◽  
Critical Time ◽  
Departure Time ◽  
Time Point

scholarly journals Biomechanical and Histomorphometric Characterizations of Osseointegration during Mini-Screw Healing in Rabbit Tibiae*

2009 ◽  
Vol 79 (3) ◽  
pp. 558-563 ◽  
Author(s):  
Jing Wu ◽  
Yu-Xing Bai ◽  
Bang-Kang Wang
Keyword(s):  
Continuous Process ◽  
Critical Time ◽  
Healing Time ◽  
New Bone Formation ◽  
Biomechanical Stability ◽  
Maximum Torque ◽  
Rabbit Tibia ◽  
Pullout Load ◽  
Stability Measurements ◽  
Time Point

Abstract Objective: To evaluate effects of different healing times on integration of titanium mini-screws and bones under unloaded conditions. Materials and Methods: Biomechanical stability measurements and histomorphometric observations were performed in a rabbit tibia model after different healing times: 0 (immediate) and 1, 2, 4, and 8 weeks. Results: Biomechanical stability and both maximum torque and maximum pullout load increased with healing time but increased significantly only after 4 weeks. Maximum torque and maximum pullout load both significantly correlated with healing time and with each other. Similarly, histomorphometric analyses showed that new bone formation increased with healing time but increased dramatically only after 4 weeks. The data may provide guidance for determining optimal implant plans in clinical practice. Conclusion: Mini-screw healing is a continuous process, and week 4 is a critical time point in this process.

Effects of critical time-point for selection of early cleaving 2-cell embryos on the pregnancy outcomes of IVF

2008 ◽  
Vol 90 ◽  
pp. S215
Author(s):  
J.-K. Joo ◽  
J.-R. Choi ◽  
K.-R. Ko ◽  
K.-S. Jung ◽  
Y.-Y. Kim ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Critical Time ◽  
Selection Of ◽  
Time Point

Critical time point for apoptotic cell death in an experimental ischemia/reperfusion model and the effect of N-acetylcystein

2017 ◽  
Vol 42 (3) ◽  
Author(s):  
Gonen Ozsarlak-Sozer ◽  
Mustafa Emre ◽  
Serhat Demirkol ◽  
Arbil Açıkalın ◽  
Salih Çetiner ◽  
...  
Keyword(s):  
Cell Death ◽  
Kidney Transplantation ◽  
Apoptotic Cell ◽  
Ischemia Reperfusion ◽  
Critical Time ◽  
Apoptotic Cell Death ◽  
Renal Ischemia ◽  
Albino Rats ◽  
Long Distance ◽  
Time Point

AbstractObjective:Kidney transplantation is an important treatment option in end stage renal failure. Tissue death may be an important problem when a kidney is removed from a cadaver and transported to a donor a long distance away. The purpose of this study is to determine the critical time point for apoptotic cell death in a renal ischemia/reperfusion model and determine the effects of N-acetylcystein on apoptosis induced by ischemia injury.Methods:Apoptotic cell death after induced renal ischemia followed by reperfusion, was estimated in a group of Wistar albino rats by immunoflourescence and ELISA techniques. N-acetylcystein, an antioxidant agent, was given to the rats to study the effect on apoptosis. Tissues were examined immunohistochemically at 0, 1 h, 24 h, 5 days and 10 days for detection of apoptotic cells.Results:Our results showed that an ischemia for 60 min followed by reperfusion for 60 min triggered apoptosis. Moreover, N-acetylcystein significantly diminished both the ischemia/reperfusion damage and apoptosis.Conclusion:We anticipate our results would be important for kidney transplantation in estimating the critical time point for apoptosis and administration of N-acetylcystein prior to removal of the organ may be important in delaying the onset of apoptosis.

scholarly journals The abrupt pathological deterioration of cisplatin‐induced acute kidney injury: Emerging of a critical time point

2021 ◽  
Vol 9 (6) ◽  
Author(s):  
Qin Gong ◽  
Mulan Wang ◽  
Ya Jiang ◽  
Chengliang Zha ◽  
Dong Yu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Critical Time ◽  
Kidney Injury ◽  
Time Point

scholarly journals ARHGAP29 Mutation Is Associated with Abnormal Oral Epithelial Adhesions

2017 ◽  
Vol 96 (11) ◽  
pp. 1298-1305 ◽  
Author(s):  
B.J. Paul ◽  
K. Palmer ◽  
J.C. Sharp ◽  
C.H. Pratt ◽  
S.A. Murray ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Critical Time ◽  
Craniofacial Development ◽  
Loss Of Function ◽  
Single Nucleotide ◽  
Increased Risk ◽  
Keratin 17 ◽  
Oral Epithelial ◽  
Time Point

Nonsyndromic cleft lip and/or palate (NSCL/P) is a prevalent birth defect of complex etiology. Previous studies identified mutations in ARHGAP29 associated with an increased risk for NSCL/P. To investigate the effects of ARHGAP29 in vivo, we generated a novel murine allele by inserting a point mutation identified in a patient with NSCL/P. This single-nucleotide variation of ARHGAP29 translates to an early nonsense mutation (K326X), presumably resulting in loss-of-function (LoF). Embryos from Arhgap29K326X/+ intercrosses were harvested at various time points. No homozygous Arhgap29K326X animals were found in the 45 analyzed litters, assessed as early as embryonic day 8.5 (e8.5). Coronal sectioning of e13.5 and e14.5 heads revealed that 59% of Arhgap29K326X/+ mice ( n = 37) exhibited improper epithelial contact between developing oral structures, while none were observed in wild types ( n = 10). In addition, Arhgap29K326X/+ embryos exhibited a significantly higher percentage of maxillary epithelium in contact with mandibular epithelium. Immunofluorescent analyses of the periderm and oral adhesions revealed the presence of Arhgap29 in periderm cells. These cells were p63 negative, keratin 17 positive, and keratin 6 positive and present at sites of adhesion, although occasionally disorganized. Oral adhesions did not appear to impair palatogenesis, as all analyzed Arhgap29K326X/+ embryos showed confluent palatal mesenchyme and epithelium at e18.5 ( n = 16), and no mice were found with a cleft at birth. Collectively, our data demonstrate that ARHGAP29 is required for embryonic survival and that heterozygosity for LoF variants of Arhgap29 increases the incidence and length of oral adhesions at a critical time point during orofacial development. In conclusion, we validate the LoF nature of the human K326X mutation in vivo and reveal a previously unknown effect of Arhgap29 in murine craniofacial development.

Advanced Concepts: Critical Time Point Based Approaches

2017 ◽  
pp. 43-57
Author(s):  
Venkata M. V. Gunturi ◽  
Shashi Shekhar
Keyword(s):  
Critical Time ◽  
Time Point
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