Multiscale Modeling and Analysis of Planar Cell Polarity in the Drosophila Wing

2013 ◽  
Vol 10 (2) ◽  
pp. 337-351 ◽  
Author(s):  
Qian Gao ◽  
David Gilbert ◽  
Monika Heiner ◽  
Fei Liu ◽  
Daniele Maccagnola ◽  
...  
Keyword(s):  
Cell Polarity ◽  
Multiscale Modeling ◽  
Planar Cell Polarity ◽  
Modeling And Analysis ◽  
Drosophila Wing

scholarly journals The Frizzled Planar Cell Polarity signaling pathway controls Drosophila wing topography

2008 ◽  
Vol 317 (1) ◽  
pp. 354-367 ◽  
Author(s):  
Kristy Doyle ◽  
Justin Hogan ◽  
Meagan Lester ◽  
Simon Collier
Keyword(s):  
Signaling Pathway ◽  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Drosophila Wing

scholarly journals Coordination of planar cell polarity pathways through Spiny-legs

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Abhijit A Ambegaonkar ◽  
Kenneth D Irvine
Keyword(s):  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Drosophila Wing ◽  
Direct Linkage ◽  
The Relationship

Morphogenesis and physiology of tissues and organs requires planar cell polarity (PCP) systems that orient and coordinate cells and their behaviors, but the relationship between PCP systems has been controversial. We have characterized how the Frizzled and Dachsous-Fat PCP systems are connected through the Spiny-legs isoform of the Prickle-Spiny-legs locus. Two different components of the Dachsous-Fat system, Dachsous and Dachs, can each independently interact with Spiny-legs and direct its localization in vivo. Through characterization of the contributions of Prickle, Spiny-legs, Dachsous, Fat, and Dachs to PCP in the Drosophila wing, eye, and abdomen, we define where Dachs-Spiny-legs and Dachsous-Spiny-legs interactions contribute to PCP, and provide a new understanding of the orientation of polarity and the basis of PCP phenotypes. Our results support the direct linkage of PCP systems through Sple in specific locales, while emphasizing that cells can be subject to and must ultimately resolve distinct, competing PCP signals.

scholarly journals Wnt ligands are not required for planar cell polarity in the Drosophila wing or notum

2020 ◽  
Author(s):  
Ben Ewen-Campen ◽  
Typhaine Comyn ◽  
Eric Vogt ◽  
Norbert Perrimon
Keyword(s):  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Wnt Signaling Pathway ◽  
Loss Of Function ◽  
Knock Out ◽  
The Core ◽  
Drosophila Wing ◽  
Wnt Ligands ◽  
Pcp Signaling ◽  
Dual Functions

AbstractThe frizzled (fz) and disheveled (dsh) genes are highly conserved members of the core planar cell polarity (PCP) pathway and of the Wnt signaling pathway. Given these dual functions, a number of studies have examined whether Wnt ligands may provide a global, tissue-scale orientation cue for PCP establishment during development, and these studies have reached differing conclusions. In this study, we re-examine this issue in the Drosophila melanogaster wing and notum using split-Gal4 co-expression analysis, systematic pairwise and triple somatic CRISPR-based knock-outs and double RNAi experiments. Pairwise loss-of-function experiments targeting wg together with other Wnt genes does not produce PCP defects, neither via somatic CRISPR nor RNAi. In addition, somatic knock-out of evi (aka wntless), which is required for the secretion of all Wnt ligands expressed in these tissues, did not produce detectable PCP phenotypes. Altogether, we were unable to find support for the hypothesis that Wnt ligands contribute to PCP signaling in the Drosophila wing or notum.

scholarly journals dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing

2013 ◽  
Vol 379 (1) ◽  
pp. 76-91 ◽  
Author(s):  
Paul N. Adler ◽  
Lukasz F. Sobala ◽  
DeSean Thom ◽  
Ranganayaki Nagaraj
Keyword(s):  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Drosophila Wing
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