A data-driven approach to classifying daily continuous glucose monitoring (CGM) time series

Author(s):  
Benjamin Lobo ◽  
Leon Farhy ◽  
Mahdi Shafiei ◽  
Boris Kovatchev
2008 ◽  
Vol 4 (3) ◽  
pp. 181-192 ◽  
Author(s):  
Giovanni Sparacino ◽  
Andrea Facchinetti ◽  
Alberto Maran ◽  
Claudio Cobelli

Author(s):  
Li Li ◽  
Jie Sun ◽  
Liemin Ruan ◽  
Qifa Song

Abstract Context There is a challenge to predict treatment effects in patients with T2DM. Objective To assess and predict treatment effects in patients with T2DM through time-series analysis of continuous glucose monitoring (CGM) measurements. Design We extracted and clustered the trend components of CGM measurements to generate representative time-series profiles, which were used as a predictor of treatment effects in groups of patients. Setting and Participants We recruited 111 outpatients with T2DM at Ningbo City First Hospital. Intervention The patients underwent CGM measurement for 14 days at the beginning of glucose-lowering treatment. Main Outcome Measures HbA1c and FPG were obtained at the beginning and 6-month of treatment. Results 111 patients each had 960 –1344 CGM measurements for 14 days at 96 measurements per day. The patients were classified into three groups according to the profiles of trend components of CGM observed values by time-series clustering method, including decreasing (47 patients), increasing (26 patients), and unchanged (38 patients) profiles. After six-month glucose-lowering treatment, FPG declined from 10.2 to 6.8 mmol/L (a decline of 3.5 mmol/L) in the decreasing group, from 8.9 to 9.2 mmol/L (a rise of 0.3 mmol/L) in the increasing group, and from 8.4 to 7.5 mmol/L (a decline of 0.9 mmol/L). The changes of HbA1c were 2.2%, 0.2%, and 0.9% for the three groups (P<0.01), respectively. Conclusions Clustering of the trend components of CGM data generates representative CGM profiles that are predictive of six-month therapeutic effects for T2DM.


2018 ◽  
Vol 28 (7) ◽  
pp. 075502 ◽  
Author(s):  
Francisco Traversaro ◽  
Francisco O. Redelico ◽  
Marcelo R. Risk ◽  
Alejandro C. Frery ◽  
Osvaldo A. Rosso

2017 ◽  
Vol 92 (8) ◽  
pp. 905-922 ◽  
Author(s):  
Yanyan Li ◽  
Caijun Xu ◽  
Lei Yi ◽  
Rongxin Fang

2021 ◽  
pp. 1-14
Author(s):  
Zhihua Zhao ◽  
Yupeng Li ◽  
Xuening Chu

Identifying defective design elements is a prerequisite for design improvements. Previous identification methods were implemented in the context of static customer requirements (CRs). However, CRs always evolve continuously, which easily leads to a failure of existing product functions in fulfilling customer expectations; this, in turn, can lead to a decline in customer satisfaction. In this study, the phenomenon is termed as ‘function obsolescence’, and a data-driven identification approach for obsolete functions is proposed for design improvements. Firstly, product operating data are employed to construct the observing parameters of functional performance (OPs), and based on the distribution of OPs, the desired level of functional performance (DL) is defined to quantitatively characterise CRs. Secondly, the time series of DL is constructed to embody the evolution of CRs, in which a Sigmoid-like function is employed to establish a dissatisfaction function. With the time series, an obsolescence index measuring the severity of obsolescence for each function is defined to identify obsolete functions. A case study was implemented on a smart phone to identify its obsolete functions to demonstrate the effectiveness of the proposed methodology. The results show that some potentially obsolete functions can be identified by the proposed method considering the evolution of CRs.


Author(s):  
Mika P. Malila ◽  
Patrik Bohlinger ◽  
Susanne Støle-Hentschel ◽  
Øyvind Breivik ◽  
Gaute Hope ◽  
...  

AbstractWe propose a methodology for despiking ocean surface wave time series based on a Bayesian approach to data-driven learning known as Gaussian Process (GP) regression. We show that GP regression can be used for both robust detection of erroneous measurements and interpolation over missing values, while also obtaining a measure of the uncertainty associated with these operations. In comparison with a recent dynamical phase space-based despiking method, our data-driven approach is here shown to lead to improved wave signal correlation and spectral tail consistency, although at a significant increase in computational cost. Our results suggest that GP regression is thus especially suited for offline quality control requiring robust noise detection and replacement, where the subsequent analysis of the despiked data is sensitive to the accidental removal of extreme or rare events such as abnormal or rogue waves. We assess our methodology on measurements from an array of four co-located 5-Hz laser altimeters during a much-studied storm event the North Sea covering a wide range of sea states.


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