scholarly journals Robust Collaborative Clustering of Subjects and Radiomic Features for Cancer Prognosis

2020 ◽  
Vol 67 (10) ◽  
pp. 2735-2744
Author(s):  
Hangfan Liu ◽  
Hongming Li ◽  
Mohamad Habes ◽  
Yuemeng Li ◽  
Pamela Boimel ◽  
...  
Keyword(s):  
Cancer Prognosis ◽  
Collaborative Clustering

242: Variants of Semaphorin 3F are Associated with Prostate Cancer Prognosis

2006 ◽  
Vol 175 (4S) ◽  
pp. 80-80
Author(s):  
Timothy C. Brand ◽  
Dawn Garcia ◽  
Edith Canby-Hagino ◽  
Ian M. Thompson ◽  
Dean Troyer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Prognosis ◽  
Semaphorin 3F ◽  
Prostate Cancer Prognosis

FADS1 is a Prognostic Biomarker in Bladder Cancer: A Study Based on TCGA Data

2020 ◽  
Vol 23 ◽  
Author(s):  
Ying Lu ◽  
Jing Shao ◽  
Xu Shu ◽  
Yaofei Jiang ◽  
Jianfang Rong ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Histological Grade ◽  
Clinical Stage ◽  
Fatty Acid Desaturase ◽  
Clinical Information ◽  
The Cancer Genome Atlas ◽  
Cancer Prognosis ◽  
Normal Tissues ◽  
Potential Biomarker ◽  
T Classification

Aim and Objective: Fatty acid desaturase 1 (FADS1) has been reported to be a potential biomarker in various cancers. However, no study has explored the relationship between FADS1 expression and bladder cancer. Our study aimed to investigate the role of FADS1 in bladder cancer prognosis via The Cancer Genome Atlas (TCGA). Materials and Methods: RNA-Seq expression of 414 tumor tissues and 19 paired normal tissues, as well as corresponding clinical data, were downloaded from TCGA database. Two cancer cases were excluded due to a lack of clinical information. The association between FADS1 and the clinicopathological features of bladder cancer was analyzed. This study was conducted in October of 2019 in China. Results: The high expression of FADS1 in bladder cancer was significantly related to histological grade (OR = 0.155 for low vs. high), clinical stage (OR=2.074 for III or IV vs. I or II), T classification (OR=2.326 for T3 or T4 vs. T1 or T2), lymphatic metastasis (OR=1.923 for N1 or N2 or N3 vs. N0) and distant metastasis (OR=4.883 for yes vs. no) (all p-values <0.05). Bladder cancer with high FADS1 levels was related to a worse prognosis than bladder cancer with low FADS1 levels (p= 1.626*10-5 ), according to median expression value 3.622. FADS1 was an independent factor of overall survival in bladder cancer, with a hazard ratio of 1.048 (95%CI: 1.020–1.077, p = 0.001). Conclusions: Increased FADS1 expression in bladder cancer is associated with advanced clinical pathological features and may be a potential biomarker for poor prognosis.

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