In Vivo Photoacoustic Sentinel Lymph Node Imaging Using Clinically-Approved Carbon Nanoparticles

2019 ◽  
pp. 1-1 ◽  
Author(s):  
Songde Liu ◽  
Hang Wang ◽  
Chenxi Zhang ◽  
Jiangning Dong ◽  
Shengchun Liu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Carbon Nanoparticles ◽  
Lymph Node Imaging

Clinical Carbon Nanoparticles Based Photoacoustic Sentinel Lymph Node Imaging In Vivo

2019 ◽  
Author(s):  
Songde Liu ◽  
Jiangning Dong ◽  
Shenchun Liu ◽  
Wenhao Huang ◽  
Ronald Xu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Carbon Nanoparticles ◽  
Lymph Node Imaging

scholarly journals Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging

2011 ◽  
Vol 2 (12) ◽  
pp. 3267 ◽  
Author(s):  
Metasebya Solomon ◽  
Brian R. White ◽  
Ralph E. Nothdruft ◽  
Walter Akers ◽  
Gail Sudlow ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Lymph Node Imaging ◽  
Fluorescence Diffuse Optical Tomography

scholarly journals Performance benchmarks of an array-based hand-held photoacoustic probe adapted from a clinical ultrasound system for non-invasive sentinel lymph node imaging

2011 ◽  
Vol 369 (1955) ◽  
pp. 4644-4650 ◽  
Author(s):  
Chulhong Kim ◽  
Todd N. Erpelding ◽  
Ladislav Jankovic ◽  
Lihong V. Wang
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Ex Vivo ◽  
Thick Layer ◽  
Chicken Breast ◽  
Breast Cancer Patients ◽  
Non Invasive ◽  
Lymph Node Imaging ◽  
Chicken Tissue

Clinical translation of photoacoustic (PA) imaging can be facilitated by integration with commercial ultrasound (US) scanners to enable dual-modality imaging. An array-based US scanner was modified for hand-held PA imaging. The performance was benchmarked in terms of signal-to-noise ratio (SNR), axial spatial resolution and sensitivity. PA images of a tube, filled with methylene blue (MB; approx. 30 mM) and placed at various depths in chicken tissue, were acquired. A 5 cm penetration depth was achieved with an 18.6 dB SNR using a laser fluence of 3 mJ cm −2 , only one-seventh of the safety limit (20 mJ cm −2 ). An axial resolution of approximately 400 μm was maintained at all imaging depths. The PA sensitivity to MB placed 2.3 cm deep in chicken tissue was less than 100 μM. Further, after intradermal injection of MB (approx. 30 mM), a rat sentinel lymph node was clearly identified in vivo , beneath a 3.8 cm thick layer of chicken breast. The accumulated concentration of MB in the node was estimated to be approximately 7 mM. The noise-equivalent sensitivities (approx. 2 cm depth) were 17 and 85 μM, ex vivo and in vivo , respectively. These results support the use of this PA system for non-invasive mapping and image-guided needle biopsy of sentinel nodes in breast cancer patients.

SPECT/CT in cervical cancer: value and advantages of preoperative sentinel lymph node imaging

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
H Hertel ◽  
R Klapdor ◽  
J Mücke ◽  
F Länger ◽  
KF Gratz ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Imaging

scholarly journals A Receptor-targeted Fluorescent Radiopharmaceutical for Multireporter Sentinel Lymph Node Imaging

Radiology ◽  
2012 ◽  
Vol 265 (1) ◽  
pp. 186-193 ◽  
Author(s):  
Derek K. Emerson ◽  
Karl K. Limmer ◽  
David J. Hall ◽  
Sung-Ho Han ◽  
William C. Eckelman ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Imaging

scholarly journals In vivo murine lymph node imaging with multispectral photoacoustic technology and clinical contrast agents

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Andrew Heinmiller ◽  
Clinton Hupple ◽  
Andrew Needles ◽  
Catherine Theodoropoulos ◽  
Ronald W Wood
Keyword(s):  
Lymph Node ◽  
Contrast Agents ◽  
Lymph Node Imaging
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