Modeling Subcutaneous Absorption of Long-Acting Insulin Glargine in Type 1 Diabetes

2020 ◽  
Vol 67 (2) ◽  
pp. 624-631 ◽  
Author(s):  
Michele Schiavon ◽  
Roberto Visentin ◽  
Clemens Giegerich ◽  
Thomas Klabunde ◽  
Claudio Cobelli ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Glargine ◽  
Acting Insulin ◽  
Subcutaneous Absorption ◽  
Long Acting

scholarly journals Effects of insulin detemir versus insulin glargine on food intake and satiety factors in type 1 diabetes

2021 ◽  
Vol 8 (1) ◽  
pp. 31-36
Author(s):  
Mark R Burge ◽  
Imaneh Fallahi ◽  
Madhavi Garimella ◽  
Steve Mitchell
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Glargine ◽  
Insulin Detemir ◽  
Peptide Yy ◽  
Caloric Intake ◽  
Research Unit ◽  
Double Blind ◽  
Acting Insulin ◽  
Long Acting

Background: Insulin detemir is long-acting insulin analog that is weight-neutral compared with other long-acting insulins in patients with type 1 diabetes. One mechanism for this may be an effect of insulin detemir to enhance satiety. We hypothesized that type 1 diabetes patients on insulin detemir will eat fewer calories when presented with a standardized buffet meal following a 24-hour fast as compared to those on insulin glargine. Methods: Ten subjects with C-peptide negative type 1 diabetes participated in a randomized, double-blind crossover study in which they received equivalent doses of either insulin detemir or insulin glargine twice daily for at least 3 weeks. They were subsequently admitted to the UNM Clinical Research Unit for a 24-hour fast, after which they were allowed to eat to satiety from a standardized buffet. Caloric consumption, hunger score and body compositions were measured. Leptin, Ghrelin and Peptide YY were assessed at baseline, after 24-hour fast, and after ingestion of the meal. Results: Subjects were aged 35±11 years, had diabetes for 18±11 years, had A1c levels of 8±1% and BMI of 30±8 kg/m2. Short acting insulin doses were higher for subjects receiving insulin detemir versus insulin glargine (p<0.001). Hunger scores, total energy ingested following the 24-hour fast, and Resting Energy Expenditure did not significant differ between the two study conditions. Conclusion: The weight-neutrality of insulin detemir in type 1 diabetes is not attributable to reduced caloric intake following a fast, or to serum satiety factors.  

Incorporating Long-Acting Insulin Glargine Into the UVA/Padova Type 1 Diabetes Simulator for In Silico Testing of MDI Therapies

2019 ◽  
Vol 66 (10) ◽  
pp. 2889-2896 ◽  
Author(s):  
Roberto Visentin ◽  
Michele Schiavon ◽  
Clemens Giegerich ◽  
Thomas Klabunde ◽  
Chiara Dalla Man ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Glargine ◽  
In Silico ◽  
Acting Insulin ◽  
Long Acting
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