Long-Term Bilayer Encapsulation Performance of Atomic Layer Deposited Al $_{\bf 2}$O$_{\bf 3}$ and Parylene C for Biomedical Implantable Devices

2013 ◽  
Vol 60 (10) ◽  
pp. 2943-2951 ◽  
Author(s):  
Xianzong Xie ◽  
Loren Rieth ◽  
Ryan Caldwell ◽  
Mohit Diwekar ◽  
Prashant Tathireddy ◽  
...  
2014 ◽  
Vol 1621 ◽  
pp. 259-265
Author(s):  
Xianzong Xie ◽  
Loren W. Rieth ◽  
Rohit Sharma ◽  
Sandeep Negi ◽  
Rajmohan Bhandari ◽  
...  

ABSTRACTLong-term functionality and stability of neural interfaces with complex geometries is one of the major challenges for chronic clinic applications due to lack of effective encapsulation. We present an encapsulation method that combines atomic layer deposited Al2O3 and Parylene C for encapsulation of biomedical implantable devices, focusing on its application on Utah electrode array based neural interfaces. The alumina and Parylene C bi-layer encapsulated wired Utah electrode array showed relatively stable impedance during the 960 equivalent soaking days at 37 °C in phosphate buffered solution. For the bi-layer coated wireless neural interfaces, the power-up frequency was constantly ∼ 910 MHz and the RF signal strength was stably around -73 dBm during equivalent soaking time of 1044 days at 37 °C (still under soak testing).


2021 ◽  
Vol 13 (13) ◽  
pp. 15761-15773
Author(s):  
Maxime Hallot ◽  
Borja Caja-Munoz ◽  
Clement Leviel ◽  
Oleg I. Lebedev ◽  
Richard Retoux ◽  
...  

2019 ◽  
Author(s):  
Timothy M. Otchy ◽  
Christos Michas ◽  
Blaire Lee ◽  
Krithi Gopalan ◽  
Jeremy Gleick ◽  
...  

ABSTRACTThe nascent field of bioelectronic medicine seeks to decode and modulate peripheral nervous system signals to obtain therapeutic control of targeted end organs and effectors. Current approaches rely heavily on electrode-based devices, but size scalability, material and microfabrication challenges, limited surgical accessibility, and the biomechanically dynamic implantation environment are significant impediments to developing and deploying advanced peripheral interfacing technologies. Here, we present a microscale implantable device – the nanoclip – for chronic interfacing with fine peripheral nerves in small animal models that begins to meet these constraints. We demonstrate the capability to make stable, high-resolution recordings of behaviorally-linked nerve activity over multi-week timescales. In addition, we show that multi-channel, current-steering-based stimulation can achieve a high degree of functionally-relevant modulatory specificity within the small scale of the device. These results highlight the potential of new microscale design and fabrication techniques for the realization of viable implantable devices for long-term peripheral interfacing.


2009 ◽  
Vol 20 (43) ◽  
pp. 434010 ◽  
Author(s):  
T Helbling ◽  
C Hierold ◽  
C Roman ◽  
L Durrer ◽  
M Mattmann ◽  
...  

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Tian-Yu Wang ◽  
Jia-Lin Meng ◽  
Zhen-Yu He ◽  
Lin Chen ◽  
Hao Zhu ◽  
...  

Catalysts ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 266 ◽  
Author(s):  
Soong Kim ◽  
Byeong Cha ◽  
Shahid Saqlain ◽  
Hyun Seo ◽  
Young Kim

In this article, the structural and chemical properties of heterogeneous catalysts prepared by atomic layer deposition (ALD) are discussed. Oxide shells can be deposited on metal particles, forming shell/core type catalysts, while metal nanoparticles are incorporated into the deep inner parts of mesoporous supporting materials using ALD. Both structures were used as catalysts for the dry reforming of methane (DRM) reaction, which converts CO2 and CH4 into CO and H2. These ALD-prepared catalysts are not only highly initially active for the DRM reaction but are also stable for long-term operation. The origins of the high catalytic activity and stability of the ALD-prepared catalysts are thoroughly discussed.


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