In Silico Evaluation of Glucose Control Protocols for Critically Ill Patients

2012 ◽  
Vol 59 (1) ◽  
pp. 54-57 ◽  
Author(s):  
Jung Chan Lee ◽  
Myeungseon Kim ◽  
Ka Ram Choi ◽  
Tae Jung Oh ◽  
Min Young Kim ◽  
...  
Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 1075-P
Author(s):  
JAMES S. KRINSLEY ◽  
PETER R. RULE ◽  
JEAN-CHARLES PREISER ◽  
GREG ROBERTS ◽  
SHEHROSE CHAUDRY ◽  
...  

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Yukari Aoyagi ◽  
Takuo Yoshida ◽  
Shigehiko Uchino ◽  
Masanori Takinami ◽  
Shoichi Uezono

Abstract Background The choice of intravenous infusion products for critically ill patients has been studied extensively because it can affect prognosis. However, there has been little research on drug diluents in this context. The purpose of this study is to evaluate the impact of diluent choice (saline or 5% dextrose in water [D5W]) on electrolyte abnormalities, blood glucose control, incidence of acute kidney injury (AKI), and mortality. Methods This before-after, two-group comparative, retrospective study enrolled adult patients who stayed for more than 48 h in a general intensive care unit from July 2015 to December 2018. We changed the default diluent for intermittent drug sets in our electronic ordering system from D5W to saline at the end of 2016. Results We included 844 patients: 365 in the D5W period and 479 in the saline period. Drug diluents accounted for 21.4% of the total infusion volume. The incidences of hypernatremia and hyperchloremia were significantly greater in the saline group compared to the D5W group (hypernatremia 27.3% vs. 14.6%, p < 0.001; hyperchloremia 36.9 % vs. 20.4%, p < 0.001). Multivariate analyses confirmed the similar effects (hypernatremia adjusted odds ratio (OR), 2.43; 95% confidence interval (CI), 1.54–3.82; hyperchloremia adjusted OR, 2.09; 95% CI, 1.31–3.34). There was no significant difference in the incidences of hyperglycemia, AKI, and mortality between the two groups. Conclusions Changing the diluent default from D5W to saline had no effect on blood glucose control and increased the incidences of hypernatremia and hyperchloremia.


2020 ◽  
Vol 48 (1) ◽  
pp. 217-217
Author(s):  
Brett Baney ◽  
Susan Lessar ◽  
Arthur Harralson ◽  
Jennifer Carter ◽  
Rachel Gaydos ◽  
...  

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