Magnetoelastic Materials as Novel Bioactive Coatings for the Control of Cell Adhesion

2011 ◽  
Vol 58 (3) ◽  
pp. 698-704 ◽  
Author(s):  
E Vlaisavljevich ◽  
L P Janka ◽  
K G Ong ◽  
R M Rajachar
Keyword(s):  
Cell Adhesion ◽  
Bioactive Coatings ◽  
Magnetoelastic Materials

Magnetoelastic Materials as Novel Bioactive Coatings to Improve Integration of Percutaneous Implants

2011 ◽  
Author(s):  
Hal Holmes ◽  
Eli Vlaisavljevich ◽  
Ee Lim Tan ◽  
Keat G. Ong ◽  
Rupak M. Rajachar
Keyword(s):  
Extracellular Matrix ◽  
Host Response ◽  
Biomedical Implants ◽  
Risk Of Infection ◽  
Bioactive Coatings ◽  
Increased Risk ◽  
Ultimate Failure ◽  
Magnetoelastic Materials ◽  
Percutaneous Implants ◽  
Fibroblastic Activity

Fibroblastic activity is an innate function of the host response. In the presence of many percutaneous biomedical implants, this activity becomes uncontrollable, resulting in significant fibrous overgrowth at the soft tissue-implant interface [1]. The aberrant cell growth associated with pathological fibrosis can lead to extensive remodeling and excessive synthesis of extracellular matrix (ECM) components, preventing proper integration [2]. Furthermore, these areas of irregular fibrotic activity can also serve as sites for opportunistic infection [3]. In brief, interfacial fibrosis is often responsible for the ultimate failure and increased risk of infection of percutaneous biomedical implants.

Magnetoelastic Materials as Novel Bioactive Coatings for Bone Anchored Prostheses

2009 ◽  
Author(s):  
Eli Vlaisavljevich ◽  
Logan P. Janka ◽  
Keat G. Ong ◽  
Rupak M. Rajachar
Keyword(s):  
Soft Tissue ◽  
Mechanical Stability ◽  
Cellular Growth ◽  
Bioactive Coatings ◽  
Extracellular Matrix Components ◽  
Anchoring System ◽  
Magnetoelastic Materials ◽  
External Connection ◽  
The Stability ◽  
A Site

Enhanced fibroblast activity at the implant-soft tissue interface is a key concern to the long-term success of many implanted biomaterials. Uncontrolled fibrosis has been shown to dramatically decrease the stability, function, and lifespan of biomedical implants. Fibrosis, defined as the overgrowth of various tissues about the implant, is caused by the excess synthesis of extracellular matrix components, primarily collagen, and often leads to walling off and hardening (calcification) of tissues at the biomaterial interface (1). Fibrosis is currently a major deterrent to stable bone anchored prostheses. These bone anchored mounting systems are designed to surgically attach a prosthesis mounting post directly into a patient’s bone. The attached post protrudes from the bone through the overlying soft tissue of the amputated limb providing an external connection point for the prosthetic. Although the bone anchoring system dramatically improves prosthetic limb mechanical stability, uncontrolled fibrosis at the soft tissue-mounting post interface is a significant problem (2). The fibrosis caused from aberrant cellular growth leads to the formation of irregular skin folds that prevent proper sealing to the bone anchoring post and also serves as a site for opportunistic infection and failure of the prosthetic system.

scholarly journals Protein adsorption and cell adhesion on nanoscale bioactive coatings formed from poly(ethylene glycol) and albumin microgels

Biomaterials ◽  
2008 ◽  
Vol 29 (34) ◽  
pp. 4481-4493 ◽  
Author(s):  
Evan A. Scott ◽  
Michael D. Nichols ◽  
Lee H. Cordova ◽  
Brandon J. George ◽  
Young-Shin Jun ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Protein Adsorption ◽  
Poly Ethylene Glycol ◽  
Bioactive Coatings ◽  
Poly Ethylene

622: Von Hippel-Lindau Inactivation Downregulates the Cell-Cell Adhesion Molecule E Cadherin in Renal Cancer Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 170-170
Author(s):  
Maxine G. Tran ◽  
Miguel A. Esteban ◽  
Peter D. Hill ◽  
Ashish Chandra ◽  
Tim S. O'Brien ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Von Hippel Lindau ◽  
E Cadherin ◽  
Cell Cell
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