Analysis of Tidal Breathing Flow Volume Loops for Automated Lung-Function Diagnosis in Infants

2010 ◽  
Vol 57 (8) ◽  
pp. 1945-1953 ◽  
Author(s):  
S Leonhardt ◽  
P Ahrens ◽  
V Kecman
Keyword(s):  
Lung Function ◽  
Flow Volume ◽  
Tidal Breathing

scholarly journals Tidal breathing flow volume profiles during sleep in wheezing infants measured by impedance pneumography

2019 ◽  
Vol 126 (5) ◽  
pp. 1409-1418 ◽  
Author(s):  
Javier Gracia-Tabuenca ◽  
Ville-Pekka Seppä ◽  
Milla Jauhiainen ◽  
Anne Kotaniemi-Syrjänen ◽  
Kristiina Malmström ◽  
...  
Keyword(s):  
Lung Function ◽  
Airway Obstruction ◽  
Eye Movement ◽  
Rapid Eye Movement ◽  
Flow Volume ◽  
Tidal Breathing ◽  
Sleep Phase ◽  
Asthma Risk ◽  
Impedance Pneumography ◽  
At Home

Overnight analysis of tidal breathing flow volume (TBFV) loops, recorded by impedance pneumography (IP), has been successfully applied in the home monitoring of children with wheezing disorders. However, little is known on how sleep physiology modifies the relationship between TBFV profiles and wheeze. We studied such interactions in wheezing infants. Forty-three infants recruited because of recurrent lower airway symptoms were divided into three groups based on their risk of asthma: high (HR), intermediate (IR), or low (LR). Sedated patients underwent infant lung function testing including assessment of airway responsiveness to methacholine at the hospital and a full-night recording of TBFV profiles at home with IP during natural sleep. Overnight TBFV indexes were estimated from periods of higher and lower respiration variability, presumably belonging to active [rapid eye movement (REM)] and quiet [non-REM (NREM)] sleep, respectively. From 35 valid recordings, absolute time indexes showed intrasubject sleep phase differences. Peak flow relative to time and volume was lower in HR compared with LR only during REM, suggesting altered expiratory control. Indexes estimating the concavity/convexity of flow decrease during exhalation suggested limited flow during passive exhale in HR compared with IR and LR, similarly during NREM and REM. Moreover, during REM convexity was negatively correlated with maximal flow at functional residual capacity and methacholine responsiveness. We conclude that TBFV profiles determined from overnight IP recordings vary because of sleep phase and asthma risk. Physiological changes during REM, most likely decrease in respiratory muscle tone, accentuate the changes in TBFV profiles caused by airway obstruction. NEW & NOTEWORTHY Impedance pneumography was used to investigate overnight tidal breathing flow volume (TBFV) indexes and their interactions with sleep phase [rapid eye movement (REM) vs. non-REM] at home in wheezing infants. The study shows that TBFV indexes vary significantly because of sleep phase and asthma risk of the infant and that during REM the changes in TBFV indexes caused by airway obstruction are accentuated and better associated with lung function of the infant.

scholarly journals Measurement of tidal breathing flows in infants using impedance pneumography

2016 ◽  
Vol 49 (2) ◽  
pp. 1600926 ◽  
Author(s):  
Leo Pekka Malmberg ◽  
Ville-Pekka Seppä ◽  
Anne Kotaniemi-Syrjänen ◽  
Kristiina Malmström ◽  
Merja Kajosaari ◽  
...  
Keyword(s):  
Lung Function ◽  
Tidal Flow ◽  
Mean Deviation ◽  
Flow Volume ◽  
Tidal Breathing ◽  
Impedance Pneumography ◽  
Similar Association ◽  
Residual Capacity ◽  
The Mean ◽  
Airway Conductance

Tidal breathing flow volume (TBFV) profiles have been used to characterise altered lung function. Impedance pneumography (IP) is a novel option for assessing TBFV curves noninvasively. The aim of this study was to extend the application of IP for infants and to estimate the agreement between IP and direct pneumotachograph (PNT) measurements in assessing tidal airflow and flow-derived indices.Tidal flow profiles were recorded for 1 min simultaneously with PNT and uncalibrated IP at baseline in 44 symptomatic infants, and after methacholine-induced bronchoconstriction in a subgroup (n=20).The agreement expressed as the mean deviation from linearity ranged between 3.9 and 4.3% of tidal peak inspiratory flow, but was associated with specific airway conductance (p=0.002) and maximal flow at functional residual capacity (V′maxFRC) (p=0.004) at baseline. Acute bronchoconstriction induced by methacholine did not significantly affect the agreement of IP with PNT. TBFV indices derived from IP were slightly underestimated compared to PNT, but were equally well repeatable and associated with baseline V′maxFRC (p=0.012 and p=0.013, respectively).TBFV profiles were consistent between IP and PNT in most infants, but the agreement was affected by reduced lung function. TBFV parameters were not interchangeable between IP and PNT, but had a similar association with lung function in infants.

scholarly journals Haemoglobin, iron status and lung function of adolescents participating in organised sports in the Finnish Health Promoting Sports Club Study

2020 ◽  
Vol 6 (1) ◽  
pp. e000804
Author(s):  
Kerttu Toivo ◽  
Pekka Kannus ◽  
Sami Kokko ◽  
Lauri Alanko ◽  
Olli J Heinonen ◽  
...  
Keyword(s):  
Lung Function ◽  
Iron Status ◽  
Haemoglobin Concentration ◽  
Cross Sectional Study ◽  
Flow Volume ◽  
Cross Sectional ◽  
Ferritin Concentration ◽  
Supplement Use ◽  
Laboratory Test Results ◽  
Study Laboratory

ObjectivesTo compare laboratory test results and lung function of adolescent organised sports participants (SP) with non-participants (NP).MethodsIn this cross-sectional study, laboratory tests (haemoglobin, iron status), and flow-volume spirometry were performed on SP youths (199 boys, 203 girls) and their NP peers (62 boys, 114 girls) aged 14–17.ResultsHaemoglobin concentration <120/130 g/L was found in 5.8% of SP and 5.1% NP (OR 1.20, 95% CI 0.54 to 2.68). Ferritin concentration below 15 µg/L was found in 22.7% of both SP and NP girls. Among boys ferritin <30 µg/L was found in 26.5% of SP and 30.2% of NP (OR 0.76, 95% CI 0.40 to 1.47). Among SP iron supplement use was reported by 3.5% of girls and 1.5% of boys. In flow-volume spirometry with bronchodilation test, 7.0% of SP and 6.4% of NP had asthma-like findings (OR 1.17, 95% CI 0.54 to 2.54); those using asthma medication, that is, 9.8% of SP and 5.2% of NP were excluded from the analysis.ConclusionsScreening for iron deficiency is recommended for symptomatic persons and persons engaging in sports. Lung function testing is recommended for symptomatic persons and persons participating in sports in which asthma is more prevalent.

Effect of changes in lung volume on respiratory system compliance in newborn infants

1989 ◽  
Vol 67 (3) ◽  
pp. 1192-1197 ◽  
Author(s):  
F. Ratjen ◽  
R. Zinman ◽  
A. R. Stark ◽  
L. E. Leszczynski ◽  
M. E. Wohl
Keyword(s):  
Tidal Volume ◽  
Respiratory System ◽  
Lung Volume ◽  
Newborn Infants ◽  
Face Mask ◽  
Flow Volume ◽  
Respiratory System Compliance ◽  
Tidal Breathing ◽  
Volume Changes ◽  
Passive Flow

Total respiratory system compliance (Crs) at volumes above the tidal volume (VT) was studied by use of the expiratory volume clamping (EVC) technique in 10 healthy sleeping unsedated newborn infants. Flow was measured with a pneumotachograph attached to a face mask and integrated to yield volume. Volume changes were confirmed by respiratory inductance plethysmography. Crs measured by EVC was compared with Crs during tidal breathing determined by the passive flow-volume (PFV) technique. Volume increases of approximately 75% VT were achieved with three to eight inspiratory efforts during expiratory occlusions. Crs above VT was consistently greater than during tidal breathing (P less than 0.0005). This increase in Crs likely reflects recruitment of lung units that are closed or atelectatic in the VT range. Within the VT range, Crs measured by PFV was compared with that obtained by the multiple-occlusion method (MO). PFV yielded greater values of Crs than MO (P less than 0.01). This may be due to braking of expiratory airflow after the release of an occlusion or nonlinearity of Crs. Thus both volume recruitment and airflow retardation may affect the measurement of Crs in unsedated newborn infants.

scholarly journals Airway obstruction is associated with reduced variability in specific parts of the tidal breathing flow–volume curve in young children

2019 ◽  
Vol 5 (2) ◽  
pp. 00028-2019 ◽  
Author(s):  
Ville-Pekka Seppä ◽  
Anton Hult ◽  
Javier Gracia-Tabuenca ◽  
Marita Paassilta ◽  
Jari Viik ◽  
...  
Keyword(s):  
Young Children ◽  
Airway Obstruction ◽  
Flow Volume ◽  
Tidal Breathing ◽  
Volume Curve ◽  
Flow Volume Curve

Can Tidal Breathing Flow Volume Loops Be Used To Measure Airway Obstruction In Infants?

2012 ◽  
Author(s):  
Avigdor Hevroni ◽  
Shlomo Cohen ◽  
Lior Bendov ◽  
Aliza Goldman ◽  
Avraham Avital ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Flow Volume ◽  
Tidal Breathing

scholarly journals Lung function by tidal breathing in awake healthy newborn infants

1994 ◽  
Vol 7 (9) ◽  
pp. 1660-1668 ◽  
Author(s):  
K.C. Lødrup Carlsen ◽  
P. Magnus ◽  
K-H. Carlsen
Keyword(s):  
Lung Function ◽  
Newborn Infants ◽  
Tidal Breathing ◽  
Healthy Newborn

scholarly journals Flow-Volume Parameters in COPD Related to Extended Measurements of Lung Volume, Diffusion, and Resistance

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Linnea Jarenbäck ◽  
Jaro Ankerst ◽  
Leif Bjermer ◽  
Ellen Tufvesson
Keyword(s):  
Lung Function ◽  
Forced Expiratory Volume ◽  
Flow Volume ◽  
Impulse Oscillometry ◽  
Body Plethysmography ◽  
Additional Information ◽  
Single Breath ◽  
Gold Stage ◽  
Copd Patients ◽  
Helium Dilution

Classification of COPD into different GOLD stages is based on forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) but has shown to be of limited value. The aim of the study was to relate spirometry values to more advanced measures of lung function in COPD patients compared to healthy smokers. The lung function of 65 COPD patients and 34 healthy smokers was investigated using flow-volume spirometry, body plethysmography, single breath helium dilution with CO-diffusion, and impulse oscillometry. All lung function parameters, measured by body plethysmography, CO-diffusion, and impulse oscillometry, were increasingly affected through increasing GOLD stage but did not correlate with FEV1within any GOLD stage. In contrast, they correlated fairly well with FVC%p, FEV1/FVC, and inspiratory capacity. Residual volume (RV) measured by body plethysmography increased through GOLD stages, while RV measured by helium dilution decreased. The difference between these RV provided valuable additional information and correlated with most other lung function parameters measured by body plethysmography and CO-diffusion. Airway resistance measured by body plethysmography and impulse oscillometry correlated within COPD stages. Different lung function parameters are of importance in COPD, and a thorough patient characterization is important to understand the disease.

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