Linear Electrode Arrays for Stimulation and Recording Within Cardiac Tissue Space Constants

2008 ◽  
Vol 55 (4) ◽  
pp. 1408-1414 ◽  
Author(s):  
A.E. Pollard ◽  
C.D. Ellis ◽  
W.M. Smith
Keyword(s):  
Cardiac Tissue ◽  
Electrode Arrays ◽  
Tissue Space ◽  
Linear Electrode Arrays

IS THE DISCRETE COUPLING OF CARDIAC CELLS REFLECTED IN THE WAVEFRONT OF EXTRACELLULAR POTENTIALS? — AN EXPERIMENTAL APPROACH

1996 ◽  
Vol 06 (09) ◽  
pp. 1767-1773 ◽  
Author(s):  
ERNST HOFER ◽  
GÜNTHER MOHR ◽  
ANA CLAUDIA JORGE ◽  
DIETER PLATZER ◽  
INGRID SCHAFFERHOFER
Keyword(s):  
Continuous Medium ◽  
Cardiac Tissue ◽  
Experimental Approach ◽  
Temporal Distribution ◽  
Cardiac Cells ◽  
Electrode Arrays ◽  
Cardiac Impulse ◽  
Spatio Temporal ◽  
Remarkable Progress

In recent years there has been a remarkable progress in the knowledge of the microstructure of the cardiac tissue and its influence on the conduction of the cardiac impulse. The tissue domain can be thought as a discrete network of cells coupled electrically at stochastically distributed sites. During in-vitro experiments the tissue is surrounded by a conducting superfusate which represents a continuous domain. With electrode arrays, electrograms can be recorded simultaneously at many sites in this volume conductor and the spatio-temporal distribution of potentials can be obtained. In this paper we show, that despite the fact that the sensors were placed in a continuous medium, we were able to detect microscopic discontinuities of propagation with appropriate techniques.

Impedance imaging using linear electrode arrays

1987 ◽  
Vol 8 (4A) ◽  
pp. 109-118 ◽  
Author(s):  
H M Powell ◽  
D C Barber ◽  
I L Freeston
Keyword(s):  
Electrode Arrays ◽  
Impedance Imaging ◽  
Linear Electrode Arrays

Cytopathology of Cardiac Tissue from Daunomycin-Treated Mice

1971 ◽  
Vol 29 ◽  
pp. 550-551
Author(s):  
Robert H. Liss ◽  
Frances A. Cotton
Keyword(s):  
Cardiac Tissue ◽  
Cardiac Toxicity ◽  
Drug Distribution ◽  
Personal Communication ◽  
Intravenous Dose ◽  
Single Intravenous Dose ◽  
Physiologic Saline ◽  
Histopathologic Changes ◽  
Distribution Studies ◽  
Lung And Kidney

Daunomycin, an antibiotic used in the clinical management of acute leukemia, produces a delayed, lethal cardiac toxicity. The lethality is dose and schedule dependent; histopathologic changes induced by the drug have been described in heart, lung, and kidney from hamsters in both single and multiple dose studies. Mice given a single intravenous dose of daunomycin (10 mg/kg) die 6-7 days later. Drug distribution studies indicate that the rodents excrete most of a single dose of the drug as daunomycin and metabolite within 48 hours after dosage (M. A. Asbell, personal communication).Myocardium from the ventricles of 6 moribund BDF1 mice which had received a single intravenous dose of daunomycin (10 mg/kg), and from controls dosed with physiologic saline, was fixed in glutaraldehyde and prepared for electron microscopy.

Iron storage sites in the myocardium as revealed by cytohistochemistry

1988 ◽  
Vol 46 ◽  
pp. 394-395
Author(s):  
M. Ashraf ◽  
F. Thompson ◽  
S. Miki ◽  
P. Srivastava
Keyword(s):  
Cardiac Tissue ◽  
Coronary Perfusion ◽  
Intracellular Iron ◽  
Ether Anesthesia ◽  
Intense Staining ◽  
Iron Storage ◽  
Thin Sections ◽  
Rat Hearts ◽  
Cacodylate Buffer ◽  
Made In

Iron is believed to play an important role in the pathogenesis of ischemic injury. However, the sources of intracellular iron in myocytes are not yet defined. In this study we have attempted to localize iron at various cellular sites of the cardiac tissue with the ferrocyanide technique.Rat hearts were excised under ether anesthesia. They were fixed with coronary perfusion with 3% buffered glutaraldehyde made in 0.1 M cacodylate buffer pH 7.3. Sections, 60 μm in thickness, were cut on a vibratome and were incubated in the medium containing 500 mg of potassium ferrocyanide in 49.5 ml H2O and 0.5 ml concentrated HC1 for 30 minutes at room temperature. Following rinses in the buffer, tissues were dehydrated in ethanol and embedded in Spurr medium.The examination of thin sections revealed intense staining or reaction product in peroxisomes (Fig. 1).

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