scholarly journals An Array of Microactuated Microelectrodes for Monitoring Single-Neuronal Activity in Rodents

2005 ◽  
Vol 52 (8) ◽  
pp. 1470-1477 ◽  
Author(s):  
J. Muthuswamy ◽  
M. Okandan ◽  
A. Gilletti ◽  
M.S. Baker ◽  
T. Jain
2020 ◽  
Vol 30 (02) ◽  
pp. 2050010 ◽  
Author(s):  
Olivier Darbin ◽  
Nobuhiko Hatanaka ◽  
Sayuki Takara ◽  
Nobuya Kaneko ◽  
Satomi Chiken ◽  
...  

The changes in neuronal firing activity in the primary motor cortex (M1) and supplementary motor area (SMA) were compared in monkeys rendered parkinsonian by treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The neuronal dynamic was characterized using mathematical tools defined in different frameworks (rate, oscillations or complex patterns). Then, and for each cortical area, multivariate and discriminate analyses were further performed on these features to identify those important to differentiate between the normal and the pathological neuronal activity. Our results show a different order in the importance of the features to discriminate the pathological state in each cortical area which suggests that the M1 and the SMA exhibit dissimilarities in their neuronal alterations induced by parkinsonism. Our findings highlight the need for multiple mathematical frameworks to best characterize the pathological neuronal activity related to parkinsonism. Future translational studies are warranted to investigate the causal relationships between cortical region-specificities, dominant pathological hallmarks and symptoms.


2005 ◽  
Vol 22 (11) ◽  
pp. 2833-2844 ◽  
Author(s):  
Evgeny S. Nikitin ◽  
Igor S. Zakharov ◽  
Elena I. Samarova ◽  
György Kemenes ◽  
Pavel M. Balaban

2009 ◽  
Vol 65 ◽  
pp. S48
Author(s):  
Mao Van Can ◽  
Etsuro Hori ◽  
Anh Hai Tran ◽  
Taketoshi Ono ◽  
Hisao Nishijo

1983 ◽  
Vol 260 (1) ◽  
pp. 121-124 ◽  
Author(s):  
Shuji Aou ◽  
Yutaka Oomura ◽  
Hitoo Nishino ◽  
Taketoshi Ono ◽  
Kazutoshi Yamabe ◽  
...  

1993 ◽  
Author(s):  
Gloria E. Hoffman ◽  
◽  
Wen-Sen Lee ◽  
M. Susan Smith ◽  
Rula Abbud ◽  
...  

2004 ◽  
Author(s):  
A. A. Burikov ◽  
N. V. Svetlova ◽  
O. N. Chichinadze ◽  
O. I. Chuguev
Keyword(s):  

2006 ◽  
Author(s):  
G. J. Siegle ◽  
C. S. Carter ◽  
M. E. Thase
Keyword(s):  

1989 ◽  
Vol 28 (03) ◽  
pp. 92-94 ◽  
Author(s):  
C. Neumann ◽  
H. Baas ◽  
R. Hefner ◽  
G. Hör

The symptoms of Parkinson’s disease often begin on one side of the body and continue to do so as the disease progresses. First SPECT results in 4 patients with hemiparkinsonism using 99mTc-HMPAO as perfusion marker are reported. Three patients exhibited reduced tracer uptake in the contralateral basal ganglia One patient who was under therapy for 1 year, showed a different perfusion pattern with reduced uptake in both basal ganglia. These results might indicate reduced perfusion secondary to reduced striatal neuronal activity.


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