Histologic Changes in Continuous, Long-Term Electrical Stimulation of a Peripheral Nerve

1967 ◽  
Vol BME-14 (2) ◽  
pp. 109-114 ◽  
Author(s):  
Philip I. Hershberg ◽  
David Sohn ◽  
Girdhar P. Agrawal ◽  
Adrian Kantrowitz
Keyword(s):  
Electrical Stimulation ◽  
Peripheral Nerve ◽  
Histologic Changes ◽  
Stimulation Of

scholarly journals Case Studies in Neuroscience: Sensations elicited and discrimination ability from nerve cuff stimulation in an amputee over time

2018 ◽  
Vol 120 (1) ◽  
pp. 291-295 ◽  
Author(s):  
Rochelle Ackerley ◽  
Helena Backlund Wasling ◽  
Max Ortiz-Catalan ◽  
Rickard Brånemark ◽  
Johan Wessberg
Keyword(s):  
Electrical Stimulation ◽  
Peripheral Nerve ◽  
Sensory Feedback ◽  
Precision Grip ◽  
Just Noticeable Difference ◽  
Body Parts ◽  
Discrimination Ability ◽  
Nerve Cuff ◽  
Stimulation Of

The present case study details sensations elicited by electrical stimulation of peripheral nerve axons using an implanted nerve cuff electrode, in a participant with a transhumeral amputation. The participant uses an osseointegrated electromechanical interface, which enables skeletal attachment of the prosthesis and long-term, stable, bidirectional communication between the implanted electrodes and prosthetic arm. We focused on evoking somatosensory percepts, where we tracked and quantified the evolution of perceived sensations in the missing hand, which were evoked from electrical stimulation of the nerve, for over 2 yr. These sensations included small, pointlike areas of either vibration or pushing, to larger sensations over wider areas, indicating the recruitment of a few and many afferents, respectively. Furthermore, we used a two-alternative forced choice paradigm to measure the level of discrimination between trains of brief electrical stimuli, to gauge what the participant could reliably distinguish between. At best, the participant was able to distinguish a 0.5-Hz difference and on average acquired a 3.8-Hz just-noticeable difference at a more stringent psychophysical level. The current work shows the feasibility for long-term sensory feedback in prostheses, via electrical axonal stimulation, where small and relatively stable percepts were felt that may be used to deliver graded sensory feedback. This opens up opportunities for signaling feedback during movements (e.g., for precision grip), but also for conveying more complex cutaneous sensations, such as texture. NEW & NOTEWORTHY We demonstrate the long-term stability and generation of sensations from electrical peripheral nerve stimulation in an amputee, through an osseointegrated implant. We find that perceived tactilelike sensations could be generated for over 2 yr, in the missing hand. This is useful for prosthetic development and the implementation of feedback in artificial body parts.

Electrical stimulation of referred sensation area alleviates phantom limb pain

2021 ◽  
pp. 1-10
Author(s):  
Michihiro Osumi ◽  
Daisuke Shimizu ◽  
Yuki Nishi ◽  
Shu Morioka
Keyword(s):  
Electrical Stimulation ◽  
Single Case ◽  
Phantom Limb Pain ◽  
Phantom Limb ◽  
Long Term Effects ◽  
Limb Pain ◽  
Short Term ◽  
Analgesic Effects ◽  
Stimulation Of

Background: Patients with brachial plexus avulsion (BPA) usually experience phantom sensations and phantom limb pain (PLP) in the deafferented limb. It has been suggested that evoking the sensation of touch in the deafferented limb by stimulating referred sensation areas (RSAs) on the cheek or shoulder might alleviate PLP. However, feasible rehabilitation techniques using this approach have not been reported. Objective: The present study sought to examine the analgesic effects of simple electrical stimulation of RSAs in BPA patients with PLP. Methods: Study 1: Electrical stimulation of RSAs for 60 minutes was conducted for six BPA patients suffering from PLP to examine short-term analgesic effects. Study 2: A single case design experiment was conducted with two BPA patients to investigate whether electrical stimulation of RSAs was more effective for alleviating PLP than control electrical stimulation (electrical stimulation of sites on side opposite to the RSAs), and to elucidate the long-term effects of electrical stimulation of RSAs. Results: Study 1: Electrical stimulation of RSAs evoked phantom touch sensations in the deafferented limb, and significantly alleviated PLP (p <  0.05). Study 2: PLP was alleviated more after electrical stimulation on RSAs compared with control electrical stimulation (p <  0.05). However, the analgesic effects of electrical stimulation on RSAs were observed only in the short term, not in the long term (p >  0.05). Conclusions: Electrical stimulation of RSAs not only evoked phantom touch sensation but also alleviated PLP in the short term. The results indicate that electrical stimulation of RSAs may provide a useful practical rehabilitation technique for PLP. Future studies will be required to clarify the mechanisms underlying immediate PLP alleviation via electrical stimulation of RSAs.

Electrical Stimulation of the Ear: Clinical Applications

1983 ◽  
Vol 92 (6) ◽  
pp. 621-622 ◽  
Author(s):  
M. Portmann ◽  
J.-M. Aran ◽  
M. Nègrevergne ◽  
Y. Cazals
Keyword(s):  
Electrical Stimulation ◽  
Round Window ◽  
Clinical Applications ◽  
Positive Currents ◽  
Stimulation Of

Electrical stimulation of the ear in humans was performed with an extracochlear electrode on the round window. With positive currents, suppression of tinnitus could be induced. With negative currents, auditory sensations were evoked. Since electrical stimulation with DC currents may be hazardous in the long term, it cannot yet be proposed for the suppression of tinnitus. However, electrically evoked hearing sensations with AC currents seem to be of definite interest for some totally deaf patients.

Long-term results of electrical stimulation of the lower esophageal sphincter for treatment of proximal GERD

2014 ◽  
Vol 28 (12) ◽  
pp. 3293-3301 ◽  
Author(s):  
Toshitaka Hoppo ◽  
Leonardo Rodríguez ◽  
Edy Soffer ◽  
Michael D. Crowell ◽  
Blair A. Jobe
Keyword(s):  
Electrical Stimulation ◽  
Lower Esophageal Sphincter ◽  
Long Term Results ◽  
Esophageal Sphincter ◽  
Stimulation Of

Direct Current Electrical Stimulation of Acupuncture Needles for Peripheral Nerve Regeneration: An Exploratory Case Series

2011 ◽  
Vol 29 (2) ◽  
pp. 88-93 ◽  
Author(s):  
Motohiro Inoue ◽  
Yasukazu Katsumi ◽  
Megumi Itoi ◽  
Tatsuya Hojo ◽  
Miwa Nakajima ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Direct Current ◽  
Peripheral Nerve Regeneration ◽  
Case Series ◽  
Stimulation Of
Sign in / Sign up

Export Citation Format

Share Document