Analysis and design of rotor MRAS speed sensorless with a novel approach

2016 ◽  
Author(s):  
I. Benlaloui ◽  
S. Drid ◽  
D. Khamari ◽  
L. Chrifi-Alaoui ◽  
B. Marhic ◽  
...  
Keyword(s):  
Speed Sensorless ◽  
Analysis And Design ◽  
Novel Approach

Manufacturability Analysis and Design Feedback System Developed Using Semantic Framework

2013 ◽  
Author(s):  
Arvind Rangarajan ◽  
Pradeep Radhakrishnan ◽  
Abha Moitra ◽  
Andrew Crapo ◽  
Dean Robinson
Keyword(s):  
Feedback System ◽  
Semantic Framework ◽  
Domain Experts ◽  
Analysis And Design ◽  
Domain Specific ◽  
Semantic Web Technology ◽  
Novel Approach ◽  
Rule Knowledge ◽  
Design And Manufacturing ◽  
Query System

Early manufacturability feedback is critical for reducing product cost and lead-time. This paper describes a new architecture and platform for authoring and applying manufacturability rules for design. The key step is to define a domain-specific ontology by creating a higher-level semantic language that describes design and manufacturing concepts relevant to specific manufacturing processes. This language has two primary uses; express design in the context of manufacturing and relate manufacturing constraints on design as declarative rules. OWL and Jena (a reasoning engine) are used in the background to reason about specific designs and provide manufacturability feedback in a client-server model. The use of Semantic Web technology makes it easier to augment manufacturability feedback with a query system for the designer that utilizes the same rule knowledge base to answer what-if scenarios. This is implemented using SPARQL and using the CAD design context and so enhances the user experience. This novel approach makes it easier for the domain experts to write or verify rules and the designers to validate concepts before changing the CAD model. This helps in maintaining the independence between the CAD platform and core enterprise knowledge. A pilot study in the sheet metal domain is implemented to demonstrate the steps necessary for complete early manufacturability analysis software and highlights the benefits of this approach.

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

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