Information is physical, so its manipulation through devices is subject to its own mechanics: the science and engineering of behavioral description, which is intermingled with classical, quantum and statistical mechanics principles. This chapter is a unification of these principles and physical laws with their implications for nanoscale. Ideas of state machines, Church-Turing thesis and its embodiment in various state machines, probabilities, Bayesian principles and entropy in its various forms (Shannon, Boltzmann, von Neumann, algorithmic) with an eye on the principle of maximum entropy as an information manipulation tool. Notions of conservation and non-conservation are applied to example circuit forms folding in adiabatic, isothermal, reversible and irreversible processes. This brings out implications of fluctuation and transitions, the interplay of errors and stability and the energy cost of determinism. It concludes discussing networks as tools to understand information flow and decision making and with an introduction to entanglement in quantum computing.