Solving Consensus Using Structural Failure Models

Polymeric materials, due to their excellent physicochemical properties and versatility found applicability in multiples areas, including biomaterials used in tissue regeneration, prosthetics (hip, artificial valves), medical devices, controlled drug delivery systems, etc. Medical devices and their applications are very important in modern medicine and the need to develop new materials with improved properties or to improve the existent materials is increasing every day. Numerous reasearches are activated in this domain in order to obtain materials/surfaces that does not have drawbacks such as structural failure, calcifications, infections or thrombosis. One of the most used material is poly(vinylchloride) (PVC) due to its unique properties, availability and low cost. The most common method used for obtaining tubular devices that meet the requirements of medical use is the surface modification of polymers without changing their physical and mechanical properties, in bulk. PVC is a hydrophobic polymer and therefore many research studies were conducted in order to increase the hydrophilicity of the surface by chemical modification in order to improve biocompatibility, to enhance wettability, reduce friction or to make lubricious or antimicrobial coatings. Surface modification of PVC can be achieved by several strategies, in only one step or, in some cases, in two or more steps by applying several techniques consecutively to obtain the desired modification / performances. The most common processes used for modifying the surface of PVC devices are: plasma treatment, corona discharge, chemical grafting, electric discharge, vapour deposition of metals, flame treatment, direct chemical modification (oxidation, hydrolysis, etc.) or even some physical modification of the roughness of the surface.

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Heart Failure Models: Traditional and Novel Therapy

Current Vascular Pharmacology ◽

10.2174/1570161113666150212151506 ◽

2015 ◽

Vol 13 (5) ◽

pp. 658-669 ◽

Cited By ~ 10

Author(s):

Mohamed Haidara ◽

Abdullah Assiri ◽

Hanaa Yassin ◽

Hania Ammar ◽

Milan Obradovic ◽

...

Keyword(s):

Heart Failure ◽

Novel Therapy ◽

Failure Models

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Application of genetic programming to modeling pipe failures in water distribution systems

Journal of Hydroinformatics ◽

10.2166/hydro.2010.189 ◽

2010 ◽

Vol 13 (3) ◽

pp. 419-428 ◽

Cited By ~ 12

Author(s):

Qiang Xu ◽

Qiuwen Chen ◽

Weifeng Li

Keyword(s):

Genetic Programming ◽

Distribution System ◽

Distribution Systems ◽

Water Distribution ◽

Pipe Failure ◽

Beijing City ◽

Failure Data ◽

Processing Strategies ◽

Gis Data ◽

Failure Models

The water loss from a water distribution system is a serious problem for many cities, which incurs enormous economic and social loss. However, the economic and human resource costs to exactly locate the leakage are extraordinarily high. Thus, reliable and robust pipe failure models are demanded to assess a pipe's propensity to fail. Beijing City was selected as the case study area and the pipe failure data for 19 years (1987–2005) were analyzed. Three different kinds of methods were applied to build pipe failure models. First, a statistical model was built, which discovered that the ages of leakage pipes followed the Weibull distribution. Then, two other models were developed using genetic programming (GP) with different data pre-processing strategies. The three models were compared thereafter and the best model was applied to assess the criticality of all the pipe segments of the entire water supply network in Beijing City based on GIS data.

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Biomimetic recombinant of red blood cell membranes for improved photothermal therapy

Journal of Nanobiotechnology ◽

10.1186/s12951-021-00949-7 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Pengkai Wu ◽

Xing Jiang ◽

Shuai Yin ◽

Ying Yang ◽

Tianqing Liu ◽

...

Keyword(s):

Immune Escape ◽

Green Technology ◽

Structural Failure ◽

Pharmacokinetics And Pharmacodynamics ◽

Coated Nanoparticles ◽

Rbc Membrane ◽

Delivery Platform ◽

Red Blood Cell Membranes ◽

Endogenous Proteins ◽

Active Substances

Abstract Background RBC membrane derived nanoparticles (NPs) represent an emerging platform with prolonged circulation capacity for the delivery of active substances. For functionalize derived RBCs NPs, various strategies, such as biomimetic rebuilding of RBCs, chemical modification or inserting ligands, have been carried out to improve their performance. However, one potential adverse effect for these methods is the structural failure of membrane proteins, consequently affecting its original immune escape function. Results In this study, we reported a green technology of “disassembly-reassembly” to prepare biomimetic reconstituted RBCs membrane (rRBCs) by separating the endogenous proteins and lipids from nature RBC membrane. IR780 iodide was used as a pattern drug to verify the property and feasibility of rRBCs by constructing IR780@rRBC NPs with IR780@RBC NPs and free IR780 as controls. The results demonstrated the superiority of IR780@rRBC NPs in toxicity, stability, pharmacokinetics and pharmacodynamics compared with IR780@rRBC and free IR780. Conclusions The reported “disassembly-reassembly” strategy shows great potential to produce controllable and versatile rRBC membrane-inspired delivery platform, which may be used to overcome the deficiency of functionalization in cell membrane coated nanoparticles . Graphic abstract

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