An Application of Gradual Reduction of Drug Dose to HIV Infection Model in Consideration of Drug Resistance and Drug Dose

2006 ◽  
Author(s):  
H. Chang ◽  
Nam Jo ◽  
H. Shim
Keyword(s):  
Drug Resistance ◽  
Hiv Infection ◽  
Drug Dose ◽  
Infection Model ◽  
Gradual Reduction ◽  
Hiv Infection Model

scholarly journals Dynamics Analysis and Simulation of a Modified HIV Infection Model with a Saturated Infection Rate

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Qilin Sun ◽  
Lequan Min
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Equilibrium Point ◽  
Infection Rate ◽  
Reproductive Number ◽  
Infection Model ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Hiv Rna

This paper studies a modified human immunodeficiency virus (HIV) infection differential equation model with a saturated infection rate. It is proved that if the basic virus reproductive numberR0of the model is less than one, then the infection-free equilibrium point of the model is globally asymptotically stable; ifR0of the model is more than one, then the endemic infection equilibrium point of the model is globally asymptotically stable. Based on the clinical data from HIV drug resistance database of Stanford University, using the proposed model simulates the dynamics of the two groups of patients’ anti-HIV infection treatment. The numerical simulation results are in agreement with the evolutions of the patients’ HIV RNA levels. It can be assumed that if an HIV infected individual’s basic virus reproductive numberR0<1then this person will recover automatically; if an antiretroviral therapy makes an HIV infected individual’sR0<1, this person will be cured eventually; if an antiretroviral therapy fails to suppress an HIV infected individual’s HIV RNA load to be of unpredictable level, the time that the patient’s HIV RNA level has achieved the minimum value may be the starting time that drug resistance has appeared.

scholarly journals Threshold dynamics and threshold analysis of HIV infection model with treatment

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Zhimin Chen ◽  
Xiuxiang Liu ◽  
Liling Zeng
Keyword(s):  
Hiv Infection ◽  
Time Delays ◽  
Dynamical Behavior ◽  
Infection Model ◽  
Threshold Dynamics ◽  
Positive Equilibrium ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Immunodeficiency Virus ◽  
Hiv Infection Model

Abstract In this paper, a human immunodeficiency virus (HIV) infection model that includes a protease inhibitor (PI), two intracellular delays, and a general incidence function is derived from biologically natural assumptions. The global dynamical behavior of the model in terms of the basic reproduction number $\mathcal{R}_{0}$ R 0 is investigated by the methods of Lyapunov functional and limiting system. The infection-free equilibrium is globally asymptotically stable if $\mathcal{R}_{0}\leq 1$ R 0 ≤ 1 . If $\mathcal{R}_{0}>1$ R 0 > 1 , then the positive equilibrium is globally asymptotically stable. Finally, numerical simulations are performed to illustrate the main results and to analyze thre effects of time delays and the efficacy of the PI on $\mathcal{R}_{0}$ R 0 .

scholarly journals Bifurcation Analysis of an Age Structured HIV Infection Model with Both Virus-to-Cell and Cell-to-Cell Transmissions

2018 ◽  
Vol 28 (09) ◽  
pp. 1850109 ◽  
Author(s):  
Xiangming Zhang ◽  
Zhihua Liu
Keyword(s):  
T Cells ◽  
Hopf Bifurcation ◽  
Hiv Infection ◽  
Bifurcation Analysis ◽  
Dynamical Behavior ◽  
Infection Model ◽  
Positive Equilibrium ◽  
Semilinear Equations ◽  
Age Structured ◽  
Hiv Infection Model

We make a mathematical analysis of an age structured HIV infection model with both virus-to-cell and cell-to-cell transmissions to understand the dynamical behavior of HIV infection in vivo. In the model, we consider the proliferation of uninfected CD[Formula: see text] T cells by a logistic function and the infected CD[Formula: see text] T cells are assumed to have an infection-age structure. Our main results concern the Hopf bifurcation of the model by using the theory of integrated semigroup and the Hopf bifurcation theory for semilinear equations with nondense domain. Bifurcation analysis indicates that there exist some parameter values such that this HIV infection model has a nontrivial periodic solution which bifurcates from the positive equilibrium. The numerical simulations are also carried out.

Time-varying pharmacodynamics in a simple non-integer HIV infection model

2019 ◽  
Vol 307 ◽  
pp. 1-12 ◽  
Author(s):  
Carla M.A. Pinto ◽  
Ana R.M. Carvalho ◽  
João N. Tavares
Keyword(s):  
Hiv Infection ◽  
Infection Model ◽  
Time Varying ◽  
Hiv Infection Model

Quasilinearization-Lagrangian method to solve the HIV infection model of CD4 $$^+$$ + T cells

SeMA Journal ◽  
2017 ◽  
Vol 75 (2) ◽  
pp. 271-283 ◽  
Author(s):  
Kourosh Parand ◽  
Zahra Kalantari ◽  
Mehdi Delkhosh
Keyword(s):  
T Cells ◽  
Hiv Infection ◽  
Cd4 T Cells ◽  
Lagrangian Method ◽  
Infection Model ◽  
Hiv Infection Model
Sign in / Sign up

Export Citation Format

Share Document