Bridging the Research-Industry Gap: The Case for Domain Modeling

2015 ◽  
Author(s):  
Pamela Zave
Keyword(s):  
Domain Modeling

scholarly journals Saccharomyces cerevisiae elongation factor 2. Genetic cloning, characterization of expression, and G-domain modeling.

1992 ◽  
Vol 267 (2) ◽  
pp. 1190-1197 ◽  
Author(s):  
J P Perentesis ◽  
L D Phan ◽  
W B Gleason ◽  
D C LaPorte ◽  
D M Livingston ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Elongation Factor ◽  
Domain Modeling ◽  
Elongation Factor 2

An Efficient Preconditioner for Linear System Solution in Multi-Domain Modeling of the Circulatory System

2013 ◽  
Author(s):  
Mahdi Esmaily Moghadam ◽  
Yuri Bazilevs ◽  
Tain-Yen Hsia ◽  
Alison Marsden
Keyword(s):  
Strong Coupling ◽  
Large Scale ◽  
Computational Cost ◽  
Circulatory System ◽  
Flow Simulation ◽  
Global Dynamics ◽  
Domain Modeling ◽  
Computationally Efficient ◽  
Lumped Parameter ◽  
System Solution

A closed-loop lumped parameter network (LPN) coupled to a 3D domain is a powerful tool that can be used to model the global dynamics of the circulatory system. Coupling a 0D LPN to a 3D CFD domain is a numerically challenging problem, often associated with instabilities, extra computational cost, and loss of modularity. A computationally efficient finite element framework has been recently proposed that achieves numerical stability without sacrificing modularity [1]. This type of coupling introduces new challenges in the linear algebraic equation solver (LS), producing an strong coupling between flow and pressure that leads to an ill-conditioned tangent matrix. In this paper we exploit this strong coupling to obtain a novel and efficient algorithm for the linear solver (LS). We illustrate the efficiency of this method on several large-scale cardiovascular blood flow simulation problems.

Prediction of VH-VL domain orientation for antibody variable domain modeling

2015 ◽  
Vol 83 (4) ◽  
pp. 681-695 ◽  
Author(s):  
Alexander Bujotzek ◽  
James Dunbar ◽  
Florian Lipsmeier ◽  
Wolfgang Schäfer ◽  
Iris Antes ◽  
...  
Keyword(s):  
Variable Domain ◽  
Domain Modeling ◽  
Domain Orientation
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