On-Chip Control of DNA Immobilization and Hybridization with Nanosecond Electric Field Pulses

Author(s):  
R. Cabeca ◽  
D.M.F. Prazeres ◽  
V. Chu ◽  
J.P. Conde
2020 ◽  
Vol 20 (19) ◽  
pp. 11044-11065 ◽  
Author(s):  
Lewis Keeble ◽  
Nicolas Moser ◽  
Jesus Rodriguez-Manzano ◽  
Pantelis Georgiou
Keyword(s):  

2019 ◽  
Vol 5 (3) ◽  
pp. 1900669 ◽  
Author(s):  
Daniel Havelka ◽  
Djamel Eddine Chafai ◽  
Ondrej Krivosudský ◽  
Anastasiya Klebanovych ◽  
František Vostárek ◽  
...  

2020 ◽  
Vol 6 (40) ◽  
pp. eaba5457 ◽  
Author(s):  
Samiran Choudhury ◽  
Avinash Kumar Chaurasiya ◽  
Amrit Kumar Mondal ◽  
Bivas Rana ◽  
Katsuya Miura ◽  
...  

Development of energy-efficient on-demand magnonic nanochannels (MNCs) can revolutionize on-chip data communication and processing. We have developed a dynamic MNC array by periodically tailoring perpendicular magnetic anisotropy using the electric field. Brillouin light scattering spectroscopy is used to probe the spin wave (SW) dispersion of MNCs formed by applying a static electric field at the CoFeB/MgO interface through the one-dimensional stripe-like array of indium tin oxide electrodes placed on top of Ta/CoFeB/MgO/Al2O3 heterostructures. Magnonic bands, consisting of two SW frequency modes, appear with a bandgap under the application of moderate gate voltage, which can be switched off by withdrawing the voltage. The experimental results are reproduced by plane wave method–based numerical calculations, and simulated SW mode profiles show propagating SWs through nanochannels with different magnetic properties. The anticrossing between these two modes gives rise to the observed magnonic bandgap.


Author(s):  
Jie Wu ◽  
Kai Yang ◽  
Quan Yuan

For biofluids, very limited voltage can be applied without causing reactions, even with AC voltages, so conventional electrokinetic pumps cannot function effectively. Here two innovative ACEK micropump designs are proposed, which are expected to solve the long-standing problem of on-chip pumping for biofluids. This work focuses on exploiting external heat flux or temperature bias to enhance micropumping by AC electrothermal effect. AC electrothermal effect is ubiquitous as long as electric current flows through fluid. Investigating the interplay between electric field and temperature field will be useful for the research area of electrokinetics as a whole. New methods to enhance on chip micorpumping have been presented in this paper. Inhomogenous electric fields can cause uneven Joule heating of the fluid, which generates thermal gradients and leads to mobile charges in fluid bulk. The two pumping schemes circumvent the voltage problem by introducing extra thermal gradient to generate mobile charges. The free charges then move under the electric field and induce microflows due to viscosity. Numerical simulation and preliminary experiments have successfully demonstrated the improvement in flow velocity. It enriches the repertoire for the design of ACEK micropump, and affords us more flexibility when dealing with micropumping tasks. The micropumping mechanisms proposed here are simple, robust, of small form factor, can be readily integrated into microsystems at low cost. The proposed fabrication and micropump integration process is highly manufacturable with various materials and can be easily incorporated into a fully integrated biochip. The added design flexibility from this project will lend the pump design well towards many lab-on-a-chip applications.


2008 ◽  
Vol 1092 ◽  
Author(s):  
Ricardo Cabeca ◽  
D. M.F. Prazeres ◽  
V. Chu ◽  
J. P. Conde

AbstractThe on-chip application of single, sub-ms voltage pulses promotes the immobilization of single stranded DNA (ssDNA) probes from a solution to a chemically functionalized SiO2 surface and as well as the hybridization between ssDNA targets from a solution to covalently immobilized ssDNA probes (E-assisted DNA reactions). Compared to diffusion-based surface reactions (in the absence of the applied electric field), an improvement of several orders of magnitude in the kinetics of the immobilization and hybridization reactions is observed with low amplitude (below 2 V) and short duration (100 ns to 1 ms) voltage pulses. E-assisted DNA reactions are demonstrated using mm-size macroelectrodes and then optimized using μm-size microelectrodes.


Author(s):  
Gilles F. Feutmba ◽  
Artur Hermans ◽  
John P. George ◽  
Irfan Ansari ◽  
Dries Van Thourhout ◽  
...  

2006 ◽  
Vol 16 (02) ◽  
pp. 437-441
Author(s):  
Lester F. Eastman ◽  
William J. Schaff ◽  
Ho-Young Cha ◽  
Xiao-Dong Chen ◽  
Michael G. Spencer ◽  
...  

A short drift distance N - I - N device, with high electric field, allows ballistic electron accelerations and drift. Conditions can be enhanced by using a heterojunction to launch electrons at finite energy. Initial I(V) results without the heterojunctions are presented, as well as the design of a structure which has the heterostructure, projected results are speculated upon, along with an on-chip circuit being used.


Biomaterials ◽  
2020 ◽  
Vol 226 ◽  
pp. 119522 ◽  
Author(s):  
Sharmistha Naskar ◽  
Viswanathan Kumaran ◽  
Yogananda S. Markandeya ◽  
Bhupesh Mehta ◽  
Bikramjit Basu

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